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Relapse of a group 4 medulloblastoma after 18 years as proven by histology and DNA methylation profiling

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Relapse of a group 4 medulloblastoma after 18 years as proven by histology and DNA methylation profiling. / Ricklefs, Franz L; Fritzsche, Friederike; Winkler, Beate; Meissner, Barbara; Dührsen, Lasse; Westphal, Manfred; Rutkowski, Stefan; Martens, Tobias; Schüller, Ulrich.

in: CHILD NERV SYST, Jahrgang 35, Nr. 6, 06.2019, S. 1029-1033.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ricklefs, FL, Fritzsche, F, Winkler, B, Meissner, B, Dührsen, L, Westphal, M, Rutkowski, S, Martens, T & Schüller, U 2019, 'Relapse of a group 4 medulloblastoma after 18 years as proven by histology and DNA methylation profiling', CHILD NERV SYST, Jg. 35, Nr. 6, S. 1029-1033. https://doi.org/10.1007/s00381-019-04086-3

APA

Ricklefs, F. L., Fritzsche, F., Winkler, B., Meissner, B., Dührsen, L., Westphal, M., Rutkowski, S., Martens, T., & Schüller, U. (2019). Relapse of a group 4 medulloblastoma after 18 years as proven by histology and DNA methylation profiling. CHILD NERV SYST, 35(6), 1029-1033. https://doi.org/10.1007/s00381-019-04086-3

Vancouver

Ricklefs FL, Fritzsche F, Winkler B, Meissner B, Dührsen L, Westphal M et al. Relapse of a group 4 medulloblastoma after 18 years as proven by histology and DNA methylation profiling. CHILD NERV SYST. 2019 Jun;35(6):1029-1033. https://doi.org/10.1007/s00381-019-04086-3

Bibtex

@article{e0c4ab91589840388b4649a71b5727b5,
title = "Relapse of a group 4 medulloblastoma after 18 years as proven by histology and DNA methylation profiling",
abstract = "BACKGROUND: Recent studies on medulloblastomas (MB) suggest that a large fraction of tumors appearing as late recurrence turn out to be secondary malignancies, e.g., malignant gliomas, after thorough molecular investigation.RESULTS: Here, we report of a patient with a group 4 MB that developed a distant recurrence after more than 18 years. The recurrent tumor was confirmed by histology and genome-wide DNA methylation profiling.CONCLUSION: Our case not only illustrates the potential of very late recurrences after seemingly cured group 4 MB, but also illustrates that detailed molecular analyses are indispensable in patients with a history of a previous malignancy.",
keywords = "Journal Article",
author = "Ricklefs, {Franz L} and Friederike Fritzsche and Beate Winkler and Barbara Meissner and Lasse D{\"u}hrsen and Manfred Westphal and Stefan Rutkowski and Tobias Martens and Ulrich Sch{\"u}ller",
year = "2019",
month = jun,
doi = "10.1007/s00381-019-04086-3",
language = "English",
volume = "35",
pages = "1029--1033",
journal = "CHILD NERV SYST",
issn = "0256-7040",
publisher = "Springer",
number = "6",

}

RIS

TY - JOUR

T1 - Relapse of a group 4 medulloblastoma after 18 years as proven by histology and DNA methylation profiling

AU - Ricklefs, Franz L

AU - Fritzsche, Friederike

AU - Winkler, Beate

AU - Meissner, Barbara

AU - Dührsen, Lasse

AU - Westphal, Manfred

AU - Rutkowski, Stefan

AU - Martens, Tobias

AU - Schüller, Ulrich

PY - 2019/6

Y1 - 2019/6

N2 - BACKGROUND: Recent studies on medulloblastomas (MB) suggest that a large fraction of tumors appearing as late recurrence turn out to be secondary malignancies, e.g., malignant gliomas, after thorough molecular investigation.RESULTS: Here, we report of a patient with a group 4 MB that developed a distant recurrence after more than 18 years. The recurrent tumor was confirmed by histology and genome-wide DNA methylation profiling.CONCLUSION: Our case not only illustrates the potential of very late recurrences after seemingly cured group 4 MB, but also illustrates that detailed molecular analyses are indispensable in patients with a history of a previous malignancy.

AB - BACKGROUND: Recent studies on medulloblastomas (MB) suggest that a large fraction of tumors appearing as late recurrence turn out to be secondary malignancies, e.g., malignant gliomas, after thorough molecular investigation.RESULTS: Here, we report of a patient with a group 4 MB that developed a distant recurrence after more than 18 years. The recurrent tumor was confirmed by histology and genome-wide DNA methylation profiling.CONCLUSION: Our case not only illustrates the potential of very late recurrences after seemingly cured group 4 MB, but also illustrates that detailed molecular analyses are indispensable in patients with a history of a previous malignancy.

KW - Journal Article

U2 - 10.1007/s00381-019-04086-3

DO - 10.1007/s00381-019-04086-3

M3 - SCORING: Journal article

C2 - 30796558

VL - 35

SP - 1029

EP - 1033

JO - CHILD NERV SYST

JF - CHILD NERV SYST

SN - 0256-7040

IS - 6

ER -