Relapse of a group 4 medulloblastoma after 18 years as proven by histology and DNA methylation profiling
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Relapse of a group 4 medulloblastoma after 18 years as proven by histology and DNA methylation profiling. / Ricklefs, Franz L; Fritzsche, Friederike; Winkler, Beate; Meissner, Barbara; Dührsen, Lasse; Westphal, Manfred; Rutkowski, Stefan; Martens, Tobias; Schüller, Ulrich.
In: CHILD NERV SYST, Vol. 35, No. 6, 06.2019, p. 1029-1033.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Relapse of a group 4 medulloblastoma after 18 years as proven by histology and DNA methylation profiling
AU - Ricklefs, Franz L
AU - Fritzsche, Friederike
AU - Winkler, Beate
AU - Meissner, Barbara
AU - Dührsen, Lasse
AU - Westphal, Manfred
AU - Rutkowski, Stefan
AU - Martens, Tobias
AU - Schüller, Ulrich
PY - 2019/6
Y1 - 2019/6
N2 - BACKGROUND: Recent studies on medulloblastomas (MB) suggest that a large fraction of tumors appearing as late recurrence turn out to be secondary malignancies, e.g., malignant gliomas, after thorough molecular investigation.RESULTS: Here, we report of a patient with a group 4 MB that developed a distant recurrence after more than 18 years. The recurrent tumor was confirmed by histology and genome-wide DNA methylation profiling.CONCLUSION: Our case not only illustrates the potential of very late recurrences after seemingly cured group 4 MB, but also illustrates that detailed molecular analyses are indispensable in patients with a history of a previous malignancy.
AB - BACKGROUND: Recent studies on medulloblastomas (MB) suggest that a large fraction of tumors appearing as late recurrence turn out to be secondary malignancies, e.g., malignant gliomas, after thorough molecular investigation.RESULTS: Here, we report of a patient with a group 4 MB that developed a distant recurrence after more than 18 years. The recurrent tumor was confirmed by histology and genome-wide DNA methylation profiling.CONCLUSION: Our case not only illustrates the potential of very late recurrences after seemingly cured group 4 MB, but also illustrates that detailed molecular analyses are indispensable in patients with a history of a previous malignancy.
KW - Journal Article
U2 - 10.1007/s00381-019-04086-3
DO - 10.1007/s00381-019-04086-3
M3 - SCORING: Journal article
C2 - 30796558
VL - 35
SP - 1029
EP - 1033
JO - CHILD NERV SYST
JF - CHILD NERV SYST
SN - 0256-7040
IS - 6
ER -