Prognostic role of proliferating CD8+ cytotoxic Tcells in human cancers
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Prognostic role of proliferating CD8+ cytotoxic Tcells in human cancers. / Blessin, Niclas C; Li, Wenchao; Mandelkow, Tim; Jansen, Hannah L; Yang, Cheng; Raedler, Jonas B; Simon, Ronald; Büscheck, Franziska; Dum, David; Luebke, Andreas M; Hinsch, Andrea; Möller, Katharina; Menz, Anne; Bernreuther, Christian; Lebok, Patrick; Clauditz, Till; Sauter, Guido; Marx, Andreas; Uhlig, Ria; Wilczak, Waldemar; Minner, Sarah; Krech, Till; Fraune, Christoph; Höflmayer, Doris; Burandt, Eike; Steurer, Stefan.
in: CELL ONCOL, Jahrgang 44, Nr. 4, 08.2021, S. 793-803.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Prognostic role of proliferating CD8+ cytotoxic Tcells in human cancers
AU - Blessin, Niclas C
AU - Li, Wenchao
AU - Mandelkow, Tim
AU - Jansen, Hannah L
AU - Yang, Cheng
AU - Raedler, Jonas B
AU - Simon, Ronald
AU - Büscheck, Franziska
AU - Dum, David
AU - Luebke, Andreas M
AU - Hinsch, Andrea
AU - Möller, Katharina
AU - Menz, Anne
AU - Bernreuther, Christian
AU - Lebok, Patrick
AU - Clauditz, Till
AU - Sauter, Guido
AU - Marx, Andreas
AU - Uhlig, Ria
AU - Wilczak, Waldemar
AU - Minner, Sarah
AU - Krech, Till
AU - Fraune, Christoph
AU - Höflmayer, Doris
AU - Burandt, Eike
AU - Steurer, Stefan
PY - 2021/8
Y1 - 2021/8
N2 - PURPOSE: Expansion of CD8+ cytotoxic Tlymphocytes is a prerequisite for anti-cancer immune activity and has gained interest in the era of immune checkpoint therapy.METHODS: To understand the CD8+ T cell dynamics in the tumor microenvironment, we used multiplex fluorescence immunohistochemistry to quantitate CD8+ proliferation (Ki67 co-expression) in tissue microarrays from 1107 colorectal, 642 renal cell, 1066 breast, 375 ovarian, 451 pancreatic and 347 gastric cancer samples.RESULTS: The density and the percentage of proliferating (Ki67+) CD8+ T cells were both highly variable between tumor types as well as between patients with the same tumor type. Elevated density and percentage of proliferating CD8+ cytotoxic T cells were significantly associated with favorable tumor parameters such as low tumor stage, negative nodal stage (p ≤ 0.0041 each), prolonged overall survival (p ≤ 0.0028 each) and an inflamed immune phenotype (p = 0.0025) in colorectal cancer and, in contrast, linked to high tumor stage, advanced ISUP/Fuhrman/Thoenes grading (each p ≤ 0.003), shorter overall survival (p ≤ 0.0330 each) and an immune inflamed phenotype (p = 0.0094) in renal cell cancer. In breast, ovarian, pancreatic and gastric cancer the role of (Ki67+)CD8+ Tcells was not linked to clinicopathological data.CONCLUSION: Our data demonstrate a tumor type dependent prognostic impact of proliferating (Ki67+)CD8+ Tcells and an inverse impact in colorectal and renal cell cancer.
AB - PURPOSE: Expansion of CD8+ cytotoxic Tlymphocytes is a prerequisite for anti-cancer immune activity and has gained interest in the era of immune checkpoint therapy.METHODS: To understand the CD8+ T cell dynamics in the tumor microenvironment, we used multiplex fluorescence immunohistochemistry to quantitate CD8+ proliferation (Ki67 co-expression) in tissue microarrays from 1107 colorectal, 642 renal cell, 1066 breast, 375 ovarian, 451 pancreatic and 347 gastric cancer samples.RESULTS: The density and the percentage of proliferating (Ki67+) CD8+ T cells were both highly variable between tumor types as well as between patients with the same tumor type. Elevated density and percentage of proliferating CD8+ cytotoxic T cells were significantly associated with favorable tumor parameters such as low tumor stage, negative nodal stage (p ≤ 0.0041 each), prolonged overall survival (p ≤ 0.0028 each) and an inflamed immune phenotype (p = 0.0025) in colorectal cancer and, in contrast, linked to high tumor stage, advanced ISUP/Fuhrman/Thoenes grading (each p ≤ 0.003), shorter overall survival (p ≤ 0.0330 each) and an immune inflamed phenotype (p = 0.0094) in renal cell cancer. In breast, ovarian, pancreatic and gastric cancer the role of (Ki67+)CD8+ Tcells was not linked to clinicopathological data.CONCLUSION: Our data demonstrate a tumor type dependent prognostic impact of proliferating (Ki67+)CD8+ Tcells and an inverse impact in colorectal and renal cell cancer.
U2 - 10.1007/s13402-021-00601-4
DO - 10.1007/s13402-021-00601-4
M3 - SCORING: Journal article
C2 - 33864611
VL - 44
SP - 793
EP - 803
JO - CELL ONCOL
JF - CELL ONCOL
SN - 2211-3428
IS - 4
ER -