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Prognostic role of proliferating CD8+ cytotoxic Tcells in human cancers

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Prognostic role of proliferating CD8+ cytotoxic Tcells in human cancers. / Blessin, Niclas C; Li, Wenchao; Mandelkow, Tim; Jansen, Hannah L; Yang, Cheng; Raedler, Jonas B; Simon, Ronald; Büscheck, Franziska; Dum, David; Luebke, Andreas M; Hinsch, Andrea; Möller, Katharina; Menz, Anne; Bernreuther, Christian; Lebok, Patrick; Clauditz, Till; Sauter, Guido; Marx, Andreas; Uhlig, Ria; Wilczak, Waldemar; Minner, Sarah; Krech, Till; Fraune, Christoph; Höflmayer, Doris; Burandt, Eike; Steurer, Stefan.

In: CELL ONCOL, Vol. 44, No. 4, 08.2021, p. 793-803.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Blessin, NC, Li, W, Mandelkow, T, Jansen, HL, Yang, C, Raedler, JB, Simon, R, Büscheck, F, Dum, D, Luebke, AM, Hinsch, A, Möller, K, Menz, A, Bernreuther, C, Lebok, P, Clauditz, T, Sauter, G, Marx, A, Uhlig, R, Wilczak, W, Minner, S, Krech, T, Fraune, C, Höflmayer, D, Burandt, E & Steurer, S 2021, 'Prognostic role of proliferating CD8+ cytotoxic Tcells in human cancers', CELL ONCOL, vol. 44, no. 4, pp. 793-803. https://doi.org/10.1007/s13402-021-00601-4

APA

Blessin, N. C., Li, W., Mandelkow, T., Jansen, H. L., Yang, C., Raedler, J. B., Simon, R., Büscheck, F., Dum, D., Luebke, A. M., Hinsch, A., Möller, K., Menz, A., Bernreuther, C., Lebok, P., Clauditz, T., Sauter, G., Marx, A., Uhlig, R., ... Steurer, S. (2021). Prognostic role of proliferating CD8+ cytotoxic Tcells in human cancers. CELL ONCOL, 44(4), 793-803. https://doi.org/10.1007/s13402-021-00601-4

Vancouver

Blessin NC, Li W, Mandelkow T, Jansen HL, Yang C, Raedler JB et al. Prognostic role of proliferating CD8+ cytotoxic Tcells in human cancers. CELL ONCOL. 2021 Aug;44(4):793-803. https://doi.org/10.1007/s13402-021-00601-4

Bibtex

@article{0602ca60736a456da088be52aa725267,
title = "Prognostic role of proliferating CD8+ cytotoxic Tcells in human cancers",
abstract = "PURPOSE: Expansion of CD8+ cytotoxic Tlymphocytes is a prerequisite for anti-cancer immune activity and has gained interest in the era of immune checkpoint therapy.METHODS: To understand the CD8+ T cell dynamics in the tumor microenvironment, we used multiplex fluorescence immunohistochemistry to quantitate CD8+ proliferation (Ki67 co-expression) in tissue microarrays from 1107 colorectal, 642 renal cell, 1066 breast, 375 ovarian, 451 pancreatic and 347 gastric cancer samples.RESULTS: The density and the percentage of proliferating (Ki67+) CD8+ T cells were both highly variable between tumor types as well as between patients with the same tumor type. Elevated density and percentage of proliferating CD8+ cytotoxic T cells were significantly associated with favorable tumor parameters such as low tumor stage, negative nodal stage (p ≤ 0.0041 each), prolonged overall survival (p ≤ 0.0028 each) and an inflamed immune phenotype (p = 0.0025) in colorectal cancer and, in contrast, linked to high tumor stage, advanced ISUP/Fuhrman/Thoenes grading (each p ≤ 0.003), shorter overall survival (p ≤ 0.0330 each) and an immune inflamed phenotype (p = 0.0094) in renal cell cancer. In breast, ovarian, pancreatic and gastric cancer the role of (Ki67+)CD8+ Tcells was not linked to clinicopathological data.CONCLUSION: Our data demonstrate a tumor type dependent prognostic impact of proliferating (Ki67+)CD8+ Tcells and an inverse impact in colorectal and renal cell cancer.",
author = "Blessin, {Niclas C} and Wenchao Li and Tim Mandelkow and Jansen, {Hannah L} and Cheng Yang and Raedler, {Jonas B} and Ronald Simon and Franziska B{\"u}scheck and David Dum and Luebke, {Andreas M} and Andrea Hinsch and Katharina M{\"o}ller and Anne Menz and Christian Bernreuther and Patrick Lebok and Till Clauditz and Guido Sauter and Andreas Marx and Ria Uhlig and Waldemar Wilczak and Sarah Minner and Till Krech and Christoph Fraune and Doris H{\"o}flmayer and Eike Burandt and Stefan Steurer",
year = "2021",
month = aug,
doi = "10.1007/s13402-021-00601-4",
language = "English",
volume = "44",
pages = "793--803",
journal = "CELL ONCOL",
issn = "2211-3428",
publisher = "Springer Netherlands",
number = "4",

}

RIS

TY - JOUR

T1 - Prognostic role of proliferating CD8+ cytotoxic Tcells in human cancers

AU - Blessin, Niclas C

AU - Li, Wenchao

AU - Mandelkow, Tim

AU - Jansen, Hannah L

AU - Yang, Cheng

AU - Raedler, Jonas B

AU - Simon, Ronald

AU - Büscheck, Franziska

AU - Dum, David

AU - Luebke, Andreas M

AU - Hinsch, Andrea

AU - Möller, Katharina

AU - Menz, Anne

AU - Bernreuther, Christian

AU - Lebok, Patrick

AU - Clauditz, Till

AU - Sauter, Guido

AU - Marx, Andreas

AU - Uhlig, Ria

AU - Wilczak, Waldemar

AU - Minner, Sarah

AU - Krech, Till

AU - Fraune, Christoph

AU - Höflmayer, Doris

AU - Burandt, Eike

AU - Steurer, Stefan

PY - 2021/8

Y1 - 2021/8

N2 - PURPOSE: Expansion of CD8+ cytotoxic Tlymphocytes is a prerequisite for anti-cancer immune activity and has gained interest in the era of immune checkpoint therapy.METHODS: To understand the CD8+ T cell dynamics in the tumor microenvironment, we used multiplex fluorescence immunohistochemistry to quantitate CD8+ proliferation (Ki67 co-expression) in tissue microarrays from 1107 colorectal, 642 renal cell, 1066 breast, 375 ovarian, 451 pancreatic and 347 gastric cancer samples.RESULTS: The density and the percentage of proliferating (Ki67+) CD8+ T cells were both highly variable between tumor types as well as between patients with the same tumor type. Elevated density and percentage of proliferating CD8+ cytotoxic T cells were significantly associated with favorable tumor parameters such as low tumor stage, negative nodal stage (p ≤ 0.0041 each), prolonged overall survival (p ≤ 0.0028 each) and an inflamed immune phenotype (p = 0.0025) in colorectal cancer and, in contrast, linked to high tumor stage, advanced ISUP/Fuhrman/Thoenes grading (each p ≤ 0.003), shorter overall survival (p ≤ 0.0330 each) and an immune inflamed phenotype (p = 0.0094) in renal cell cancer. In breast, ovarian, pancreatic and gastric cancer the role of (Ki67+)CD8+ Tcells was not linked to clinicopathological data.CONCLUSION: Our data demonstrate a tumor type dependent prognostic impact of proliferating (Ki67+)CD8+ Tcells and an inverse impact in colorectal and renal cell cancer.

AB - PURPOSE: Expansion of CD8+ cytotoxic Tlymphocytes is a prerequisite for anti-cancer immune activity and has gained interest in the era of immune checkpoint therapy.METHODS: To understand the CD8+ T cell dynamics in the tumor microenvironment, we used multiplex fluorescence immunohistochemistry to quantitate CD8+ proliferation (Ki67 co-expression) in tissue microarrays from 1107 colorectal, 642 renal cell, 1066 breast, 375 ovarian, 451 pancreatic and 347 gastric cancer samples.RESULTS: The density and the percentage of proliferating (Ki67+) CD8+ T cells were both highly variable between tumor types as well as between patients with the same tumor type. Elevated density and percentage of proliferating CD8+ cytotoxic T cells were significantly associated with favorable tumor parameters such as low tumor stage, negative nodal stage (p ≤ 0.0041 each), prolonged overall survival (p ≤ 0.0028 each) and an inflamed immune phenotype (p = 0.0025) in colorectal cancer and, in contrast, linked to high tumor stage, advanced ISUP/Fuhrman/Thoenes grading (each p ≤ 0.003), shorter overall survival (p ≤ 0.0330 each) and an immune inflamed phenotype (p = 0.0094) in renal cell cancer. In breast, ovarian, pancreatic and gastric cancer the role of (Ki67+)CD8+ Tcells was not linked to clinicopathological data.CONCLUSION: Our data demonstrate a tumor type dependent prognostic impact of proliferating (Ki67+)CD8+ Tcells and an inverse impact in colorectal and renal cell cancer.

U2 - 10.1007/s13402-021-00601-4

DO - 10.1007/s13402-021-00601-4

M3 - SCORING: Journal article

C2 - 33864611

VL - 44

SP - 793

EP - 803

JO - CELL ONCOL

JF - CELL ONCOL

SN - 2211-3428

IS - 4

ER -