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Plexin-B2 controls the development of cerebellar granule cells

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Plexin-B2 controls the development of cerebellar granule cells. / Friedel, Roland H; Kerjan, Géraldine; Rayburn, Helen; Schüller, Ulrich; Sotelo, Constantino; Tessier-Lavigne, Marc; Chédotal, Alain.

in: J NEUROSCI, Jahrgang 27, Nr. 14, 04.04.2007, S. 3921-32.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Friedel, RH, Kerjan, G, Rayburn, H, Schüller, U, Sotelo, C, Tessier-Lavigne, M & Chédotal, A 2007, 'Plexin-B2 controls the development of cerebellar granule cells', J NEUROSCI, Jg. 27, Nr. 14, S. 3921-32. https://doi.org/10.1523/JNEUROSCI.4710-06.2007

APA

Friedel, R. H., Kerjan, G., Rayburn, H., Schüller, U., Sotelo, C., Tessier-Lavigne, M., & Chédotal, A. (2007). Plexin-B2 controls the development of cerebellar granule cells. J NEUROSCI, 27(14), 3921-32. https://doi.org/10.1523/JNEUROSCI.4710-06.2007

Vancouver

Friedel RH, Kerjan G, Rayburn H, Schüller U, Sotelo C, Tessier-Lavigne M et al. Plexin-B2 controls the development of cerebellar granule cells. J NEUROSCI. 2007 Apr 4;27(14):3921-32. https://doi.org/10.1523/JNEUROSCI.4710-06.2007

Bibtex

@article{8b76f7e7f1cf426a95f10d4063c12969,
title = "Plexin-B2 controls the development of cerebellar granule cells",
abstract = "Cerebellar granule cell progenitors proliferate postnatally in the upper part of the external granule cell layer (EGL) of the cerebellum. Postmitotic granule cells differentiate and migrate, tangentially in the EGL and then radially through the molecular and Purkinje cell layers. The molecular control of the transition between proliferation and differentiation in cerebellar granule cells is poorly understood. We show here that the transmembrane receptor Plexin-B2 is expressed by proliferating granule cell progenitors. To study Plexin-B2 function, we generated a targeted mutation of mouse Plexin-B2. Most Plexin-B2(-/-) mutants die at birth as a result of neural tube closure defects. Some mutants survive but their cerebellum cytoarchitecture is profoundly altered. This is correlated with a disorganization of the timing of granule cell proliferation and differentiation in the EGL. Many differentiated granule cells migrate inside the cerebellum and keep proliferating. These results reveal that Plexin-B2 controls the balance between proliferation and differentiation in granule cells.",
keywords = "Animals, Cell Differentiation, Cell Proliferation, Cerebellum, Female, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Mutation, Nerve Tissue Proteins, Receptors, Cell Surface, Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't",
author = "Friedel, {Roland H} and G{\'e}raldine Kerjan and Helen Rayburn and Ulrich Sch{\"u}ller and Constantino Sotelo and Marc Tessier-Lavigne and Alain Ch{\'e}dotal",
year = "2007",
month = apr,
day = "4",
doi = "10.1523/JNEUROSCI.4710-06.2007",
language = "English",
volume = "27",
pages = "3921--32",
journal = "J NEUROSCI",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "14",

}

RIS

TY - JOUR

T1 - Plexin-B2 controls the development of cerebellar granule cells

AU - Friedel, Roland H

AU - Kerjan, Géraldine

AU - Rayburn, Helen

AU - Schüller, Ulrich

AU - Sotelo, Constantino

AU - Tessier-Lavigne, Marc

AU - Chédotal, Alain

PY - 2007/4/4

Y1 - 2007/4/4

N2 - Cerebellar granule cell progenitors proliferate postnatally in the upper part of the external granule cell layer (EGL) of the cerebellum. Postmitotic granule cells differentiate and migrate, tangentially in the EGL and then radially through the molecular and Purkinje cell layers. The molecular control of the transition between proliferation and differentiation in cerebellar granule cells is poorly understood. We show here that the transmembrane receptor Plexin-B2 is expressed by proliferating granule cell progenitors. To study Plexin-B2 function, we generated a targeted mutation of mouse Plexin-B2. Most Plexin-B2(-/-) mutants die at birth as a result of neural tube closure defects. Some mutants survive but their cerebellum cytoarchitecture is profoundly altered. This is correlated with a disorganization of the timing of granule cell proliferation and differentiation in the EGL. Many differentiated granule cells migrate inside the cerebellum and keep proliferating. These results reveal that Plexin-B2 controls the balance between proliferation and differentiation in granule cells.

AB - Cerebellar granule cell progenitors proliferate postnatally in the upper part of the external granule cell layer (EGL) of the cerebellum. Postmitotic granule cells differentiate and migrate, tangentially in the EGL and then radially through the molecular and Purkinje cell layers. The molecular control of the transition between proliferation and differentiation in cerebellar granule cells is poorly understood. We show here that the transmembrane receptor Plexin-B2 is expressed by proliferating granule cell progenitors. To study Plexin-B2 function, we generated a targeted mutation of mouse Plexin-B2. Most Plexin-B2(-/-) mutants die at birth as a result of neural tube closure defects. Some mutants survive but their cerebellum cytoarchitecture is profoundly altered. This is correlated with a disorganization of the timing of granule cell proliferation and differentiation in the EGL. Many differentiated granule cells migrate inside the cerebellum and keep proliferating. These results reveal that Plexin-B2 controls the balance between proliferation and differentiation in granule cells.

KW - Animals

KW - Cell Differentiation

KW - Cell Proliferation

KW - Cerebellum

KW - Female

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Mutation

KW - Nerve Tissue Proteins

KW - Receptors, Cell Surface

KW - Comparative Study

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

U2 - 10.1523/JNEUROSCI.4710-06.2007

DO - 10.1523/JNEUROSCI.4710-06.2007

M3 - SCORING: Journal article

C2 - 17409257

VL - 27

SP - 3921

EP - 3932

JO - J NEUROSCI

JF - J NEUROSCI

SN - 0270-6474

IS - 14

ER -