Pas de deux in groups of four--the biogenesis of KATP channels
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Pas de deux in groups of four--the biogenesis of KATP channels. / Neagoe, Ioana; Schwappach, Blanche.
in: J MOL CELL CARDIOL, Jahrgang 38, Nr. 6, 06.2005, S. 887-94.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Pas de deux in groups of four--the biogenesis of KATP channels
AU - Neagoe, Ioana
AU - Schwappach, Blanche
PY - 2005/6
Y1 - 2005/6
N2 - The biogenesis of K(ATP) channels provides an interesting example of the assembly of structurally very different membrane protein subunits into a heterooligomeric complex. This review summarizes our current knowledge with respect to the protein domains driving heteromultimeric assembly in the endoplasmic reticulum, quality control, as well as the determinants and kinetics of subcellular sorting of the K(ATP) channel complex. The impact of disease-associated mutations on K(ATP) channel biogenesis is discussed.
AB - The biogenesis of K(ATP) channels provides an interesting example of the assembly of structurally very different membrane protein subunits into a heterooligomeric complex. This review summarizes our current knowledge with respect to the protein domains driving heteromultimeric assembly in the endoplasmic reticulum, quality control, as well as the determinants and kinetics of subcellular sorting of the K(ATP) channel complex. The impact of disease-associated mutations on K(ATP) channel biogenesis is discussed.
KW - ATP-Binding Cassette Transporters/metabolism
KW - Adenosine Triphosphate/chemistry
KW - Animals
KW - Cell Membrane/metabolism
KW - Endoplasmic Reticulum/metabolism
KW - Humans
KW - Kinetics
KW - Mutation
KW - Potassium Channels/chemistry
KW - Potassium Channels, Inwardly Rectifying/chemistry
KW - Protein Binding
KW - Protein Structure, Tertiary
KW - Receptors, Drug/metabolism
KW - Sulfonylurea Receptors
U2 - 10.1016/j.yjmcc.2004.11.023
DO - 10.1016/j.yjmcc.2004.11.023
M3 - SCORING: Review article
C2 - 15910873
VL - 38
SP - 887
EP - 894
JO - J MOL CELL CARDIOL
JF - J MOL CELL CARDIOL
SN - 0022-2828
IS - 6
ER -