Pas de deux in groups of four--the biogenesis of KATP channels

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Pas de deux in groups of four--the biogenesis of KATP channels. / Neagoe, Ioana; Schwappach, Blanche.

In: J MOL CELL CARDIOL, Vol. 38, No. 6, 06.2005, p. 887-94.

Research output: SCORING: Contribution to journalSCORING: Review articleResearch

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@article{bf8af67b64674325881d5004cbc5d7e9,
title = "Pas de deux in groups of four--the biogenesis of KATP channels",
abstract = "The biogenesis of K(ATP) channels provides an interesting example of the assembly of structurally very different membrane protein subunits into a heterooligomeric complex. This review summarizes our current knowledge with respect to the protein domains driving heteromultimeric assembly in the endoplasmic reticulum, quality control, as well as the determinants and kinetics of subcellular sorting of the K(ATP) channel complex. The impact of disease-associated mutations on K(ATP) channel biogenesis is discussed.",
keywords = "ATP-Binding Cassette Transporters/metabolism, Adenosine Triphosphate/chemistry, Animals, Cell Membrane/metabolism, Endoplasmic Reticulum/metabolism, Humans, Kinetics, Mutation, Potassium Channels/chemistry, Potassium Channels, Inwardly Rectifying/chemistry, Protein Binding, Protein Structure, Tertiary, Receptors, Drug/metabolism, Sulfonylurea Receptors",
author = "Ioana Neagoe and Blanche Schwappach",
year = "2005",
month = jun,
doi = "10.1016/j.yjmcc.2004.11.023",
language = "English",
volume = "38",
pages = "887--94",
journal = "J MOL CELL CARDIOL",
issn = "0022-2828",
publisher = "Academic Press Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - Pas de deux in groups of four--the biogenesis of KATP channels

AU - Neagoe, Ioana

AU - Schwappach, Blanche

PY - 2005/6

Y1 - 2005/6

N2 - The biogenesis of K(ATP) channels provides an interesting example of the assembly of structurally very different membrane protein subunits into a heterooligomeric complex. This review summarizes our current knowledge with respect to the protein domains driving heteromultimeric assembly in the endoplasmic reticulum, quality control, as well as the determinants and kinetics of subcellular sorting of the K(ATP) channel complex. The impact of disease-associated mutations on K(ATP) channel biogenesis is discussed.

AB - The biogenesis of K(ATP) channels provides an interesting example of the assembly of structurally very different membrane protein subunits into a heterooligomeric complex. This review summarizes our current knowledge with respect to the protein domains driving heteromultimeric assembly in the endoplasmic reticulum, quality control, as well as the determinants and kinetics of subcellular sorting of the K(ATP) channel complex. The impact of disease-associated mutations on K(ATP) channel biogenesis is discussed.

KW - ATP-Binding Cassette Transporters/metabolism

KW - Adenosine Triphosphate/chemistry

KW - Animals

KW - Cell Membrane/metabolism

KW - Endoplasmic Reticulum/metabolism

KW - Humans

KW - Kinetics

KW - Mutation

KW - Potassium Channels/chemistry

KW - Potassium Channels, Inwardly Rectifying/chemistry

KW - Protein Binding

KW - Protein Structure, Tertiary

KW - Receptors, Drug/metabolism

KW - Sulfonylurea Receptors

U2 - 10.1016/j.yjmcc.2004.11.023

DO - 10.1016/j.yjmcc.2004.11.023

M3 - SCORING: Review article

C2 - 15910873

VL - 38

SP - 887

EP - 894

JO - J MOL CELL CARDIOL

JF - J MOL CELL CARDIOL

SN - 0022-2828

IS - 6

ER -