Pannexin Channel Regulation of Cell Migration: Focus on Immune Cells
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Pannexin Channel Regulation of Cell Migration: Focus on Immune Cells. / Harcha, Paloma A; López-López, Tamara; Palacios, Adrián G; Sáez, Pablo J.
in: FRONT IMMUNOL, Jahrgang 12, 750480, 2021.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Pannexin Channel Regulation of Cell Migration: Focus on Immune Cells
AU - Harcha, Paloma A
AU - López-López, Tamara
AU - Palacios, Adrián G
AU - Sáez, Pablo J
N1 - Copyright © 2021 Harcha, López-López, Palacios and Sáez.
PY - 2021
Y1 - 2021
N2 - The role of Pannexin (PANX) channels during collective and single cell migration is increasingly recognized. Amongst many functions that are relevant to cell migration, here we focus on the role of PANX-mediated adenine nucleotide release and associated autocrine and paracrine signaling. We also summarize the contribution of PANXs with the cytoskeleton, which is also key regulator of cell migration. PANXs, as mechanosensitive ATP releasing channels, provide a unique link between cell migration and purinergic communication. The functional association with several purinergic receptors, together with a plethora of signals that modulate their opening, allows PANX channels to integrate physical and chemical cues during inflammation. Ubiquitously expressed in almost all immune cells, PANX1 opening has been reported in different immunological contexts. Immune activation is the epitome coordination between cell communication and migration, as leukocytes (i.e., T cells, dendritic cells) exchange information while migrating towards the injury site. In the current review, we summarized the contribution of PANX channels during immune cell migration and recruitment; although we also compile the available evidence for non-immune cells (including fibroblasts, keratinocytes, astrocytes, and cancer cells). Finally, we discuss the current evidence of PANX1 and PANX3 channels as a both positive and/or negative regulator in different inflammatory conditions, proposing a general mechanism of these channels contribution during cell migration.
AB - The role of Pannexin (PANX) channels during collective and single cell migration is increasingly recognized. Amongst many functions that are relevant to cell migration, here we focus on the role of PANX-mediated adenine nucleotide release and associated autocrine and paracrine signaling. We also summarize the contribution of PANXs with the cytoskeleton, which is also key regulator of cell migration. PANXs, as mechanosensitive ATP releasing channels, provide a unique link between cell migration and purinergic communication. The functional association with several purinergic receptors, together with a plethora of signals that modulate their opening, allows PANX channels to integrate physical and chemical cues during inflammation. Ubiquitously expressed in almost all immune cells, PANX1 opening has been reported in different immunological contexts. Immune activation is the epitome coordination between cell communication and migration, as leukocytes (i.e., T cells, dendritic cells) exchange information while migrating towards the injury site. In the current review, we summarized the contribution of PANX channels during immune cell migration and recruitment; although we also compile the available evidence for non-immune cells (including fibroblasts, keratinocytes, astrocytes, and cancer cells). Finally, we discuss the current evidence of PANX1 and PANX3 channels as a both positive and/or negative regulator in different inflammatory conditions, proposing a general mechanism of these channels contribution during cell migration.
KW - Adenine Nucleotides/physiology
KW - Aging/immunology
KW - Animals
KW - Astrocytes/physiology
KW - Cell Movement/physiology
KW - Cell Polarity
KW - Chemotaxis, Leukocyte/physiology
KW - Connexins/physiology
KW - Cytoskeleton/physiology
KW - Dendritic Cells/physiology
KW - Fibroblasts/physiology
KW - Humans
KW - Inflammation/immunology
KW - Keratinocytes/physiology
KW - Leukocytes/physiology
KW - Mechanotransduction, Cellular/physiology
KW - Neoplasms/immunology
KW - Nerve Degeneration/immunology
KW - Nerve Tissue Proteins/physiology
KW - Phagocytes/physiology
KW - Receptors, Purinergic/physiology
U2 - 10.3389/fimmu.2021.750480
DO - 10.3389/fimmu.2021.750480
M3 - SCORING: Review article
C2 - 34975840
VL - 12
JO - FRONT IMMUNOL
JF - FRONT IMMUNOL
SN - 1664-3224
M1 - 750480
ER -