Pannexin Channel Regulation of Cell Migration: Focus on Immune Cells

Paloma A Harcha; Tamara López-López; Adrián G Palacios; Pablo J Sáez

doi:10.3389/fimmu.2021.750480

Pannexin Channel Regulation of Cell Migration: Focus on Immune Cells

Standard

Pannexin Channel Regulation of Cell Migration: Focus on Immune Cells. / Harcha, Paloma A; López-López, Tamara; Palacios, Adrián G; Sáez, Pablo J.

In: FRONT IMMUNOL, Vol. 12, 750480, 2021.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Harcha, PA, López-López, T, Palacios, AG & Sáez, PJ 2021, 'Pannexin Channel Regulation of Cell Migration: Focus on Immune Cells', FRONT IMMUNOL, vol. 12, 750480. https://doi.org/10.3389/fimmu.2021.750480

APA

Harcha, P. A., López-López, T., Palacios, A. G., & Sáez, P. J. (2021). Pannexin Channel Regulation of Cell Migration: Focus on Immune Cells. FRONT IMMUNOL, 12, [750480]. https://doi.org/10.3389/fimmu.2021.750480

Vancouver

Harcha PA, López-López T, Palacios AG, Sáez PJ. Pannexin Channel Regulation of Cell Migration: Focus on Immune Cells. FRONT IMMUNOL. 2021;12. 750480. https://doi.org/10.3389/fimmu.2021.750480

Bibtex

@article{f2cc0d269df249d69bdc18a37caa16ee,

title = "Pannexin Channel Regulation of Cell Migration: Focus on Immune Cells",

abstract = "The role of Pannexin (PANX) channels during collective and single cell migration is increasingly recognized. Amongst many functions that are relevant to cell migration, here we focus on the role of PANX-mediated adenine nucleotide release and associated autocrine and paracrine signaling. We also summarize the contribution of PANXs with the cytoskeleton, which is also key regulator of cell migration. PANXs, as mechanosensitive ATP releasing channels, provide a unique link between cell migration and purinergic communication. The functional association with several purinergic receptors, together with a plethora of signals that modulate their opening, allows PANX channels to integrate physical and chemical cues during inflammation. Ubiquitously expressed in almost all immune cells, PANX1 opening has been reported in different immunological contexts. Immune activation is the epitome coordination between cell communication and migration, as leukocytes (i.e., T cells, dendritic cells) exchange information while migrating towards the injury site. In the current review, we summarized the contribution of PANX channels during immune cell migration and recruitment; although we also compile the available evidence for non-immune cells (including fibroblasts, keratinocytes, astrocytes, and cancer cells). Finally, we discuss the current evidence of PANX1 and PANX3 channels as a both positive and/or negative regulator in different inflammatory conditions, proposing a general mechanism of these channels contribution during cell migration.",

keywords = "Adenine Nucleotides/physiology, Aging/immunology, Animals, Astrocytes/physiology, Cell Movement/physiology, Cell Polarity, Chemotaxis, Leukocyte/physiology, Connexins/physiology, Cytoskeleton/physiology, Dendritic Cells/physiology, Fibroblasts/physiology, Humans, Inflammation/immunology, Keratinocytes/physiology, Leukocytes/physiology, Mechanotransduction, Cellular/physiology, Neoplasms/immunology, Nerve Degeneration/immunology, Nerve Tissue Proteins/physiology, Phagocytes/physiology, Receptors, Purinergic/physiology",

author = "Harcha, {Paloma A} and Tamara L{\'o}pez-L{\'o}pez and Palacios, {Adri{\'a}n G} and S{\'a}ez, {Pablo J}",

note = "Copyright {\textcopyright} 2021 Harcha, L{\'o}pez-L{\'o}pez, Palacios and S{\'a}ez.",

year = "2021",

doi = "10.3389/fimmu.2021.750480",

language = "English",

volume = "12",

journal = "FRONT IMMUNOL",

issn = "1664-3224",

publisher = "Lausanne : Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Pannexin Channel Regulation of Cell Migration: Focus on Immune Cells

AU - Harcha, Paloma A

AU - López-López, Tamara

AU - Palacios, Adrián G

AU - Sáez, Pablo J

PY - 2021

Y1 - 2021

N2 - The role of Pannexin (PANX) channels during collective and single cell migration is increasingly recognized. Amongst many functions that are relevant to cell migration, here we focus on the role of PANX-mediated adenine nucleotide release and associated autocrine and paracrine signaling. We also summarize the contribution of PANXs with the cytoskeleton, which is also key regulator of cell migration. PANXs, as mechanosensitive ATP releasing channels, provide a unique link between cell migration and purinergic communication. The functional association with several purinergic receptors, together with a plethora of signals that modulate their opening, allows PANX channels to integrate physical and chemical cues during inflammation. Ubiquitously expressed in almost all immune cells, PANX1 opening has been reported in different immunological contexts. Immune activation is the epitome coordination between cell communication and migration, as leukocytes (i.e., T cells, dendritic cells) exchange information while migrating towards the injury site. In the current review, we summarized the contribution of PANX channels during immune cell migration and recruitment; although we also compile the available evidence for non-immune cells (including fibroblasts, keratinocytes, astrocytes, and cancer cells). Finally, we discuss the current evidence of PANX1 and PANX3 channels as a both positive and/or negative regulator in different inflammatory conditions, proposing a general mechanism of these channels contribution during cell migration.

AB - The role of Pannexin (PANX) channels during collective and single cell migration is increasingly recognized. Amongst many functions that are relevant to cell migration, here we focus on the role of PANX-mediated adenine nucleotide release and associated autocrine and paracrine signaling. We also summarize the contribution of PANXs with the cytoskeleton, which is also key regulator of cell migration. PANXs, as mechanosensitive ATP releasing channels, provide a unique link between cell migration and purinergic communication. The functional association with several purinergic receptors, together with a plethora of signals that modulate their opening, allows PANX channels to integrate physical and chemical cues during inflammation. Ubiquitously expressed in almost all immune cells, PANX1 opening has been reported in different immunological contexts. Immune activation is the epitome coordination between cell communication and migration, as leukocytes (i.e., T cells, dendritic cells) exchange information while migrating towards the injury site. In the current review, we summarized the contribution of PANX channels during immune cell migration and recruitment; although we also compile the available evidence for non-immune cells (including fibroblasts, keratinocytes, astrocytes, and cancer cells). Finally, we discuss the current evidence of PANX1 and PANX3 channels as a both positive and/or negative regulator in different inflammatory conditions, proposing a general mechanism of these channels contribution during cell migration.

KW - Adenine Nucleotides/physiology

KW - Aging/immunology

KW - Animals

KW - Astrocytes/physiology

KW - Cell Movement/physiology

KW - Cell Polarity

KW - Chemotaxis, Leukocyte/physiology

KW - Connexins/physiology

KW - Cytoskeleton/physiology

KW - Dendritic Cells/physiology

KW - Fibroblasts/physiology

KW - Humans

KW - Inflammation/immunology

KW - Keratinocytes/physiology

KW - Leukocytes/physiology

KW - Mechanotransduction, Cellular/physiology

KW - Neoplasms/immunology

KW - Nerve Degeneration/immunology

KW - Nerve Tissue Proteins/physiology

KW - Phagocytes/physiology

KW - Receptors, Purinergic/physiology

U2 - 10.3389/fimmu.2021.750480

DO - 10.3389/fimmu.2021.750480

M3 - SCORING: Review article

C2 - 34975840

VL - 12

JO - FRONT IMMUNOL

JF - FRONT IMMUNOL

SN - 1664-3224

M1 - 750480

ER -