Neuroleptic withdrawal in chronic schizophrenia: CT and endocrine variables relating to psychopathology.
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Neuroleptic withdrawal in chronic schizophrenia: CT and endocrine variables relating to psychopathology. / Naber, Dieter; Albus, M; Bürke, H; Müller-Spahn, F; Münch, U; Reinertshofer, T; Wissmann, J; Ackenheil, M.
in: PSYCHIAT RES, Jahrgang 16, Nr. 3, 3, 1985, S. 207-219.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Neuroleptic withdrawal in chronic schizophrenia: CT and endocrine variables relating to psychopathology.
AU - Naber, Dieter
AU - Albus, M
AU - Bürke, H
AU - Müller-Spahn, F
AU - Münch, U
AU - Reinertshofer, T
AU - Wissmann, J
AU - Ackenheil, M
PY - 1985
Y1 - 1985
N2 - The psychopathology of 36 chronic, schizophrenic patients who had been on maintenance neuroleptics was rated during neuroleptic therapy and after 12 days of neuroleptic withdrawal. At both times, hormonal serum levels were also determined. Moreover, in 27 of these patients, ventricle-brain ratio, maximal width of the third ventricle, and sulcal widening were measured on computed tomography (CT). Neuroleptic withdrawal resulted in individually different psychopathological changes: 7 patients improved, 11 worsened. Within the whole group, thought disorder deteriorated, and anergia improved. Levels of cortisol and beta-endorphin increased; those of prolactin and norepinephrine decreased. The majority of patients showed ventricular enlargement, which was marginally related to reduced thought disorder. CT and endocrine variables were slightly related to psychopathology or psychopathological effects of neuroleptic withdrawal.
AB - The psychopathology of 36 chronic, schizophrenic patients who had been on maintenance neuroleptics was rated during neuroleptic therapy and after 12 days of neuroleptic withdrawal. At both times, hormonal serum levels were also determined. Moreover, in 27 of these patients, ventricle-brain ratio, maximal width of the third ventricle, and sulcal widening were measured on computed tomography (CT). Neuroleptic withdrawal resulted in individually different psychopathological changes: 7 patients improved, 11 worsened. Within the whole group, thought disorder deteriorated, and anergia improved. Levels of cortisol and beta-endorphin increased; those of prolactin and norepinephrine decreased. The majority of patients showed ventricular enlargement, which was marginally related to reduced thought disorder. CT and endocrine variables were slightly related to psychopathology or psychopathological effects of neuroleptic withdrawal.
M3 - SCORING: Zeitschriftenaufsatz
VL - 16
SP - 207
EP - 219
JO - PSYCHIAT RES
JF - PSYCHIAT RES
SN - 0165-1781
IS - 3
M1 - 3
ER -