NeuroCOVID: Insights into Neuroinvasion and Pathophysiology
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NeuroCOVID: Insights into Neuroinvasion and Pathophysiology. / Matschke, Jakob; Krasemann, Susanne; Altmeppen, Hermann; Shafiq, Mohsin; Glatzel, Markus.
in: Clinical and Translational Neuroscience, Jahrgang 6, Nr. 2, 10, 04.2022.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - NeuroCOVID: Insights into Neuroinvasion and Pathophysiology
AU - Matschke, Jakob
AU - Krasemann, Susanne
AU - Altmeppen, Hermann
AU - Shafiq, Mohsin
AU - Glatzel, Markus
PY - 2022/4
Y1 - 2022/4
N2 - Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may lead to acute and chronic neurological symptoms (NeuroCOVID-19). SARS-CoV-2 may spread from the respiratory tract to the central nervous system as the central nervous system (CNS) of certain patients dying from COVID-19 shows virus-related neuropathological changes. Moreover, a syndrome found in many patients having passed a SARS-CoV-2 infection, which is termed long COVID and characterized by lasting fatigue and other diverse clinical features, may well have some of its pathological correlates inside the CNS. Although knowledge on the routes of SARS-CoV-2 neuroinvasion and the pathophysiology of NeuroCOVID have increased, the molecular mechanisms are not yet fully understood. This includes the key question: to understand if observed CNS damage is a direct cause of viral damage or indirectly mediated by an overshooting neuroimmune response.
AB - Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may lead to acute and chronic neurological symptoms (NeuroCOVID-19). SARS-CoV-2 may spread from the respiratory tract to the central nervous system as the central nervous system (CNS) of certain patients dying from COVID-19 shows virus-related neuropathological changes. Moreover, a syndrome found in many patients having passed a SARS-CoV-2 infection, which is termed long COVID and characterized by lasting fatigue and other diverse clinical features, may well have some of its pathological correlates inside the CNS. Although knowledge on the routes of SARS-CoV-2 neuroinvasion and the pathophysiology of NeuroCOVID have increased, the molecular mechanisms are not yet fully understood. This includes the key question: to understand if observed CNS damage is a direct cause of viral damage or indirectly mediated by an overshooting neuroimmune response.
UR - https://www.mdpi.com/2514-183X/6/2/10
U2 - 10.3390/ctn6020010
DO - 10.3390/ctn6020010
M3 - SCORING: Review article
VL - 6
JO - Clinical and Translational Neuroscience
JF - Clinical and Translational Neuroscience
SN - 2514-183X
IS - 2
M1 - 10
ER -