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Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas

Standard

Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas. / Kirches, Elmar; Sahm, Felix; Korshunov, Andrey; Bluecher, Christina; Waldt, Natalie; Kropf, Siegfried; Schrimpf, Daniel; Sievers, Philipp; Stichel, Damian; Schüller, Ulrich; Schittenhelm, Jens; Riemenschneider, Markus J; Karajannis, Matthias A; Perry, Arie; Pietsch, Torsten; Boekhoff, Svenja; Capper, David; Beck, Katja; Paramasivam, Nagarajan; Schlesner, Matthias; Brastianos, Priscilla K; Müller, Hermann L; Pfister, Stefan M; Mawrin, Christian.

in: ACTA NEUROPATHOL, Jahrgang 142, Nr. 5, 11.2021, S. 873-886.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kirches, E, Sahm, F, Korshunov, A, Bluecher, C, Waldt, N, Kropf, S, Schrimpf, D, Sievers, P, Stichel, D, Schüller, U, Schittenhelm, J, Riemenschneider, MJ, Karajannis, MA, Perry, A, Pietsch, T, Boekhoff, S, Capper, D, Beck, K, Paramasivam, N, Schlesner, M, Brastianos, PK, Müller, HL, Pfister, SM & Mawrin, C 2021, 'Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas', ACTA NEUROPATHOL, Jg. 142, Nr. 5, S. 873-886. https://doi.org/10.1007/s00401-021-02351-x

APA

Kirches, E., Sahm, F., Korshunov, A., Bluecher, C., Waldt, N., Kropf, S., Schrimpf, D., Sievers, P., Stichel, D., Schüller, U., Schittenhelm, J., Riemenschneider, M. J., Karajannis, M. A., Perry, A., Pietsch, T., Boekhoff, S., Capper, D., Beck, K., Paramasivam, N., ... Mawrin, C. (2021). Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas. ACTA NEUROPATHOL, 142(5), 873-886. https://doi.org/10.1007/s00401-021-02351-x

Vancouver

Kirches E, Sahm F, Korshunov A, Bluecher C, Waldt N, Kropf S et al. Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas. ACTA NEUROPATHOL. 2021 Nov;142(5):873-886. https://doi.org/10.1007/s00401-021-02351-x

Bibtex

@article{5ce304a5bcb0409d9294dba1cabdf5a4,
title = "Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas",
abstract = "In contrast to adults, meningiomas are uncommon tumors in childhood and adolescence. Whether adult and pediatric meningiomas differ on a molecular level is unclear. Here we report detailed genomic analyses of 37 pediatric meningiomas by sequencing and DNA methylation profiling. Histologically, the series was dominated by meningioma subtypes with aggressive behavior, with 70% of patients suffering from WHO grade II or III meningiomas. The most frequent cytogenetic aberrations were loss of chromosomes 22 (23/37 [62%]), 1 (9/37 [24%]), 18 (7/37 [19%]), and 14 (5/37 [14%]). Tumors with NF2 alterations exhibited overall increased chromosomal instability. Unsupervised clustering of DNA methylation profiles revealed separation into three groups: designated group 1 composed of clear cell and papillary meningiomas, whereas group 2A comprised predominantly atypical meningiomas and group 2B enriched for rare high-grade subtypes (rhabdoid, chordoid). Meningiomas from NF2 patients clustered exclusively within groups 1 and 2A. When compared with a dataset of 105 adult meningiomas, the pediatric meningiomas largely grouped separately. Targeted panel DNA sequencing of 34 tumors revealed frequent NF2 alterations, while other typical alterations found in adult non-NF2 tumors were absent. These data demonstrate that pediatric meningiomas are characterized by molecular features distinct from adult tumors.",
keywords = "Adolescent, Adult, Child, Child, Preschool, Female, Gene Expression Profiling, Humans, Male, Meningeal Neoplasms/genetics, Meningioma/genetics, Transcriptome",
author = "Elmar Kirches and Felix Sahm and Andrey Korshunov and Christina Bluecher and Natalie Waldt and Siegfried Kropf and Daniel Schrimpf and Philipp Sievers and Damian Stichel and Ulrich Sch{\"u}ller and Jens Schittenhelm and Riemenschneider, {Markus J} and Karajannis, {Matthias A} and Arie Perry and Torsten Pietsch and Svenja Boekhoff and David Capper and Katja Beck and Nagarajan Paramasivam and Matthias Schlesner and Brastianos, {Priscilla K} and M{\"u}ller, {Hermann L} and Pfister, {Stefan M} and Christian Mawrin",
note = "{\textcopyright} 2021. The Author(s).",
year = "2021",
month = nov,
doi = "10.1007/s00401-021-02351-x",
language = "English",
volume = "142",
pages = "873--886",
journal = "ACTA NEUROPATHOL",
issn = "0001-6322",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas

AU - Kirches, Elmar

AU - Sahm, Felix

AU - Korshunov, Andrey

AU - Bluecher, Christina

AU - Waldt, Natalie

AU - Kropf, Siegfried

AU - Schrimpf, Daniel

AU - Sievers, Philipp

AU - Stichel, Damian

AU - Schüller, Ulrich

AU - Schittenhelm, Jens

AU - Riemenschneider, Markus J

AU - Karajannis, Matthias A

AU - Perry, Arie

AU - Pietsch, Torsten

AU - Boekhoff, Svenja

AU - Capper, David

AU - Beck, Katja

AU - Paramasivam, Nagarajan

AU - Schlesner, Matthias

AU - Brastianos, Priscilla K

AU - Müller, Hermann L

AU - Pfister, Stefan M

AU - Mawrin, Christian

N1 - © 2021. The Author(s).

PY - 2021/11

Y1 - 2021/11

N2 - In contrast to adults, meningiomas are uncommon tumors in childhood and adolescence. Whether adult and pediatric meningiomas differ on a molecular level is unclear. Here we report detailed genomic analyses of 37 pediatric meningiomas by sequencing and DNA methylation profiling. Histologically, the series was dominated by meningioma subtypes with aggressive behavior, with 70% of patients suffering from WHO grade II or III meningiomas. The most frequent cytogenetic aberrations were loss of chromosomes 22 (23/37 [62%]), 1 (9/37 [24%]), 18 (7/37 [19%]), and 14 (5/37 [14%]). Tumors with NF2 alterations exhibited overall increased chromosomal instability. Unsupervised clustering of DNA methylation profiles revealed separation into three groups: designated group 1 composed of clear cell and papillary meningiomas, whereas group 2A comprised predominantly atypical meningiomas and group 2B enriched for rare high-grade subtypes (rhabdoid, chordoid). Meningiomas from NF2 patients clustered exclusively within groups 1 and 2A. When compared with a dataset of 105 adult meningiomas, the pediatric meningiomas largely grouped separately. Targeted panel DNA sequencing of 34 tumors revealed frequent NF2 alterations, while other typical alterations found in adult non-NF2 tumors were absent. These data demonstrate that pediatric meningiomas are characterized by molecular features distinct from adult tumors.

AB - In contrast to adults, meningiomas are uncommon tumors in childhood and adolescence. Whether adult and pediatric meningiomas differ on a molecular level is unclear. Here we report detailed genomic analyses of 37 pediatric meningiomas by sequencing and DNA methylation profiling. Histologically, the series was dominated by meningioma subtypes with aggressive behavior, with 70% of patients suffering from WHO grade II or III meningiomas. The most frequent cytogenetic aberrations were loss of chromosomes 22 (23/37 [62%]), 1 (9/37 [24%]), 18 (7/37 [19%]), and 14 (5/37 [14%]). Tumors with NF2 alterations exhibited overall increased chromosomal instability. Unsupervised clustering of DNA methylation profiles revealed separation into three groups: designated group 1 composed of clear cell and papillary meningiomas, whereas group 2A comprised predominantly atypical meningiomas and group 2B enriched for rare high-grade subtypes (rhabdoid, chordoid). Meningiomas from NF2 patients clustered exclusively within groups 1 and 2A. When compared with a dataset of 105 adult meningiomas, the pediatric meningiomas largely grouped separately. Targeted panel DNA sequencing of 34 tumors revealed frequent NF2 alterations, while other typical alterations found in adult non-NF2 tumors were absent. These data demonstrate that pediatric meningiomas are characterized by molecular features distinct from adult tumors.

KW - Adolescent

KW - Adult

KW - Child

KW - Child, Preschool

KW - Female

KW - Gene Expression Profiling

KW - Humans

KW - Male

KW - Meningeal Neoplasms/genetics

KW - Meningioma/genetics

KW - Transcriptome

U2 - 10.1007/s00401-021-02351-x

DO - 10.1007/s00401-021-02351-x

M3 - SCORING: Journal article

C2 - 34495383

VL - 142

SP - 873

EP - 886

JO - ACTA NEUROPATHOL

JF - ACTA NEUROPATHOL

SN - 0001-6322

IS - 5

ER -