Minimizing Ischemia Reperfusion Injury in Xenotransplantation
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Minimizing Ischemia Reperfusion Injury in Xenotransplantation. / Patel, Parth M; Connolly, Margaret R; Coe, Taylor M; Calhoun, Anthony; Pollok, Franziska; Markmann, James F; Burdorf, Lars; Azimzadeh, Agnes; Madsen, Joren C; Pierson, Richard N.
in: FRONT IMMUNOL, Jahrgang 12, 681504, 2021.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Minimizing Ischemia Reperfusion Injury in Xenotransplantation
AU - Patel, Parth M
AU - Connolly, Margaret R
AU - Coe, Taylor M
AU - Calhoun, Anthony
AU - Pollok, Franziska
AU - Markmann, James F
AU - Burdorf, Lars
AU - Azimzadeh, Agnes
AU - Madsen, Joren C
AU - Pierson, Richard N
N1 - Copyright © 2021 Patel, Connolly, Coe, Calhoun, Pollok, Markmann, Burdorf, Azimzadeh, Madsen and Pierson.
PY - 2021
Y1 - 2021
N2 - The recent dramatic advances in preventing "initial xenograft dysfunction" in pig-to-non-human primate heart transplantation achieved by minimizing ischemia suggests that ischemia reperfusion injury (IRI) plays an important role in cardiac xenotransplantation. Here we review the molecular, cellular, and immune mechanisms that characterize IRI and associated "primary graft dysfunction" in allotransplantation and consider how they correspond with "xeno-associated" injury mechanisms. Based on this analysis, we describe potential genetic modifications as well as novel technical strategies that may minimize IRI for heart and other organ xenografts and which could facilitate safe and effective clinical xenotransplantation.
AB - The recent dramatic advances in preventing "initial xenograft dysfunction" in pig-to-non-human primate heart transplantation achieved by minimizing ischemia suggests that ischemia reperfusion injury (IRI) plays an important role in cardiac xenotransplantation. Here we review the molecular, cellular, and immune mechanisms that characterize IRI and associated "primary graft dysfunction" in allotransplantation and consider how they correspond with "xeno-associated" injury mechanisms. Based on this analysis, we describe potential genetic modifications as well as novel technical strategies that may minimize IRI for heart and other organ xenografts and which could facilitate safe and effective clinical xenotransplantation.
KW - Adaptive Immunity
KW - Animals
KW - Biomarkers
KW - Complement System Proteins/immunology
KW - Disease Management
KW - Disease Susceptibility
KW - Heterografts
KW - Humans
KW - Immunity, Innate
KW - Mitochondria/immunology
KW - Organ Specificity
KW - Organ Transplantation/adverse effects
KW - Oxidative Stress
KW - Reactive Oxygen Species/metabolism
KW - Reperfusion Injury/etiology
KW - Transplantation, Heterologous
U2 - 10.3389/fimmu.2021.681504
DO - 10.3389/fimmu.2021.681504
M3 - SCORING: Review article
C2 - 34566955
VL - 12
JO - FRONT IMMUNOL
JF - FRONT IMMUNOL
SN - 1664-3224
M1 - 681504
ER -