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Minimizing Ischemia Reperfusion Injury in Xenotransplantation

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Minimizing Ischemia Reperfusion Injury in Xenotransplantation. / Patel, Parth M; Connolly, Margaret R; Coe, Taylor M; Calhoun, Anthony; Pollok, Franziska; Markmann, James F; Burdorf, Lars; Azimzadeh, Agnes; Madsen, Joren C; Pierson, Richard N.

In: FRONT IMMUNOL, Vol. 12, 681504, 2021.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Patel, PM, Connolly, MR, Coe, TM, Calhoun, A, Pollok, F, Markmann, JF, Burdorf, L, Azimzadeh, A, Madsen, JC & Pierson, RN 2021, 'Minimizing Ischemia Reperfusion Injury in Xenotransplantation', FRONT IMMUNOL, vol. 12, 681504. https://doi.org/10.3389/fimmu.2021.681504

APA

Patel, P. M., Connolly, M. R., Coe, T. M., Calhoun, A., Pollok, F., Markmann, J. F., Burdorf, L., Azimzadeh, A., Madsen, J. C., & Pierson, R. N. (2021). Minimizing Ischemia Reperfusion Injury in Xenotransplantation. FRONT IMMUNOL, 12, [681504]. https://doi.org/10.3389/fimmu.2021.681504

Vancouver

Patel PM, Connolly MR, Coe TM, Calhoun A, Pollok F, Markmann JF et al. Minimizing Ischemia Reperfusion Injury in Xenotransplantation. FRONT IMMUNOL. 2021;12. 681504. https://doi.org/10.3389/fimmu.2021.681504

Bibtex

@article{8ef0e69c3e1b4a43925a420da933dd26,
title = "Minimizing Ischemia Reperfusion Injury in Xenotransplantation",
abstract = "The recent dramatic advances in preventing {"}initial xenograft dysfunction{"} in pig-to-non-human primate heart transplantation achieved by minimizing ischemia suggests that ischemia reperfusion injury (IRI) plays an important role in cardiac xenotransplantation. Here we review the molecular, cellular, and immune mechanisms that characterize IRI and associated {"}primary graft dysfunction{"} in allotransplantation and consider how they correspond with {"}xeno-associated{"} injury mechanisms. Based on this analysis, we describe potential genetic modifications as well as novel technical strategies that may minimize IRI for heart and other organ xenografts and which could facilitate safe and effective clinical xenotransplantation.",
keywords = "Adaptive Immunity, Animals, Biomarkers, Complement System Proteins/immunology, Disease Management, Disease Susceptibility, Heterografts, Humans, Immunity, Innate, Mitochondria/immunology, Organ Specificity, Organ Transplantation/adverse effects, Oxidative Stress, Reactive Oxygen Species/metabolism, Reperfusion Injury/etiology, Transplantation, Heterologous",
author = "Patel, {Parth M} and Connolly, {Margaret R} and Coe, {Taylor M} and Anthony Calhoun and Franziska Pollok and Markmann, {James F} and Lars Burdorf and Agnes Azimzadeh and Madsen, {Joren C} and Pierson, {Richard N}",
note = "Copyright {\textcopyright} 2021 Patel, Connolly, Coe, Calhoun, Pollok, Markmann, Burdorf, Azimzadeh, Madsen and Pierson.",
year = "2021",
doi = "10.3389/fimmu.2021.681504",
language = "English",
volume = "12",
journal = "FRONT IMMUNOL",
issn = "1664-3224",
publisher = "Lausanne : Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Minimizing Ischemia Reperfusion Injury in Xenotransplantation

AU - Patel, Parth M

AU - Connolly, Margaret R

AU - Coe, Taylor M

AU - Calhoun, Anthony

AU - Pollok, Franziska

AU - Markmann, James F

AU - Burdorf, Lars

AU - Azimzadeh, Agnes

AU - Madsen, Joren C

AU - Pierson, Richard N

N1 - Copyright © 2021 Patel, Connolly, Coe, Calhoun, Pollok, Markmann, Burdorf, Azimzadeh, Madsen and Pierson.

PY - 2021

Y1 - 2021

N2 - The recent dramatic advances in preventing "initial xenograft dysfunction" in pig-to-non-human primate heart transplantation achieved by minimizing ischemia suggests that ischemia reperfusion injury (IRI) plays an important role in cardiac xenotransplantation. Here we review the molecular, cellular, and immune mechanisms that characterize IRI and associated "primary graft dysfunction" in allotransplantation and consider how they correspond with "xeno-associated" injury mechanisms. Based on this analysis, we describe potential genetic modifications as well as novel technical strategies that may minimize IRI for heart and other organ xenografts and which could facilitate safe and effective clinical xenotransplantation.

AB - The recent dramatic advances in preventing "initial xenograft dysfunction" in pig-to-non-human primate heart transplantation achieved by minimizing ischemia suggests that ischemia reperfusion injury (IRI) plays an important role in cardiac xenotransplantation. Here we review the molecular, cellular, and immune mechanisms that characterize IRI and associated "primary graft dysfunction" in allotransplantation and consider how they correspond with "xeno-associated" injury mechanisms. Based on this analysis, we describe potential genetic modifications as well as novel technical strategies that may minimize IRI for heart and other organ xenografts and which could facilitate safe and effective clinical xenotransplantation.

KW - Adaptive Immunity

KW - Animals

KW - Biomarkers

KW - Complement System Proteins/immunology

KW - Disease Management

KW - Disease Susceptibility

KW - Heterografts

KW - Humans

KW - Immunity, Innate

KW - Mitochondria/immunology

KW - Organ Specificity

KW - Organ Transplantation/adverse effects

KW - Oxidative Stress

KW - Reactive Oxygen Species/metabolism

KW - Reperfusion Injury/etiology

KW - Transplantation, Heterologous

U2 - 10.3389/fimmu.2021.681504

DO - 10.3389/fimmu.2021.681504

M3 - SCORING: Review article

C2 - 34566955

VL - 12

JO - FRONT IMMUNOL

JF - FRONT IMMUNOL

SN - 1664-3224

M1 - 681504

ER -