Microglia targeting by adeno-associated viral vectors

Maria Stamataki; Björn Rissiek; Tim Magnus; Jakob Körbelin

doi:10.3389/fimmu.2024.1425892

Microglia targeting by adeno-associated viral vectors

Standard

Microglia targeting by adeno-associated viral vectors. / Stamataki, Maria ; Rissiek, Björn ; Magnus, Tim ; Körbelin, Jakob.

in: FRONT IMMUNOL, Jahrgang 15, 2024, S. 1425892.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Stamataki, M , Rissiek, B , Magnus, T & Körbelin, J 2024, 'Microglia targeting by adeno-associated viral vectors', FRONT IMMUNOL, Jg. 15, S. 1425892. https://doi.org/10.3389/fimmu.2024.1425892

APA

Stamataki, M., Rissiek, B., Magnus, T., & Körbelin, J. (2024). Microglia targeting by adeno-associated viral vectors. FRONT IMMUNOL, 15, 1425892. https://doi.org/10.3389/fimmu.2024.1425892

Vancouver

Stamataki M , Rissiek B , Magnus T , Körbelin J. Microglia targeting by adeno-associated viral vectors. FRONT IMMUNOL. 2024;15:1425892. https://doi.org/10.3389/fimmu.2024.1425892

Bibtex

@article{6f8813aed31b4cbfb60bcf122f4d9395,

title = "Microglia targeting by adeno-associated viral vectors",

abstract = "Microglia play a crucial role in maintaining homeostasis of the central nervous system and they are actively involved in shaping the brain's inflammatory response to stress. Among the multitude of involved molecules, purinergic receptors and enzymes are of special importance due to their ability to regulate microglia activation. By investigating the mechanisms underlying microglial responses and dysregulation, researchers can develop more precise interventions to modulate microglial behavior and alleviate neuroinflammatory processes. Studying gene function selectively in microglia, however, remains technically challenging. This review article provides an overview of adeno-associated virus (AAV)-based microglia targeting approaches, discussing potential prospects for refining these approaches to improve both specificity and effectiveness and encouraging future investigations aimed at connecting the potential of AAV-mediated microglial targeting for therapeutic benefit in neurological disorders.",

keywords = "Dependovirus/genetics, Humans, Microglia/metabolism, Genetic Vectors/genetics, Animals, Genetic Therapy/methods",

author = "Maria Stamataki and Bj{\"o}rn Rissiek and Tim Magnus and Jakob K{\"o}rbelin",

note = "Copyright {\textcopyright} 2024 Stamataki, Rissiek, Magnus and K{\"o}rbelin.",

year = "2024",

doi = "10.3389/fimmu.2024.1425892",

language = "English",

volume = "15",

pages = "1425892",

journal = "FRONT IMMUNOL",

issn = "1664-3224",

publisher = "Lausanne : Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Microglia targeting by adeno-associated viral vectors

AU - Stamataki, Maria

AU - Rissiek, Björn

AU - Magnus, Tim

AU - Körbelin, Jakob

PY - 2024

Y1 - 2024

N2 - Microglia play a crucial role in maintaining homeostasis of the central nervous system and they are actively involved in shaping the brain's inflammatory response to stress. Among the multitude of involved molecules, purinergic receptors and enzymes are of special importance due to their ability to regulate microglia activation. By investigating the mechanisms underlying microglial responses and dysregulation, researchers can develop more precise interventions to modulate microglial behavior and alleviate neuroinflammatory processes. Studying gene function selectively in microglia, however, remains technically challenging. This review article provides an overview of adeno-associated virus (AAV)-based microglia targeting approaches, discussing potential prospects for refining these approaches to improve both specificity and effectiveness and encouraging future investigations aimed at connecting the potential of AAV-mediated microglial targeting for therapeutic benefit in neurological disorders.

AB - Microglia play a crucial role in maintaining homeostasis of the central nervous system and they are actively involved in shaping the brain's inflammatory response to stress. Among the multitude of involved molecules, purinergic receptors and enzymes are of special importance due to their ability to regulate microglia activation. By investigating the mechanisms underlying microglial responses and dysregulation, researchers can develop more precise interventions to modulate microglial behavior and alleviate neuroinflammatory processes. Studying gene function selectively in microglia, however, remains technically challenging. This review article provides an overview of adeno-associated virus (AAV)-based microglia targeting approaches, discussing potential prospects for refining these approaches to improve both specificity and effectiveness and encouraging future investigations aimed at connecting the potential of AAV-mediated microglial targeting for therapeutic benefit in neurological disorders.

KW - Dependovirus/genetics

KW - Humans

KW - Microglia/metabolism

KW - Genetic Vectors/genetics

KW - Animals

KW - Genetic Therapy/methods

U2 - 10.3389/fimmu.2024.1425892

DO - 10.3389/fimmu.2024.1425892

M3 - SCORING: Review article

C2 - 39035004

VL - 15

SP - 1425892

JO - FRONT IMMUNOL

JF - FRONT IMMUNOL

SN - 1664-3224

ER -