Microglia targeting by adeno-associated viral vectors
Standard
Microglia targeting by adeno-associated viral vectors. / Stamataki, Maria; Rissiek, Björn; Magnus, Tim; Körbelin, Jakob.
In: FRONT IMMUNOL, Vol. 15, 2024, p. 1425892.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Microglia targeting by adeno-associated viral vectors
AU - Stamataki, Maria
AU - Rissiek, Björn
AU - Magnus, Tim
AU - Körbelin, Jakob
N1 - Copyright © 2024 Stamataki, Rissiek, Magnus and Körbelin.
PY - 2024
Y1 - 2024
N2 - Microglia play a crucial role in maintaining homeostasis of the central nervous system and they are actively involved in shaping the brain's inflammatory response to stress. Among the multitude of involved molecules, purinergic receptors and enzymes are of special importance due to their ability to regulate microglia activation. By investigating the mechanisms underlying microglial responses and dysregulation, researchers can develop more precise interventions to modulate microglial behavior and alleviate neuroinflammatory processes. Studying gene function selectively in microglia, however, remains technically challenging. This review article provides an overview of adeno-associated virus (AAV)-based microglia targeting approaches, discussing potential prospects for refining these approaches to improve both specificity and effectiveness and encouraging future investigations aimed at connecting the potential of AAV-mediated microglial targeting for therapeutic benefit in neurological disorders.
AB - Microglia play a crucial role in maintaining homeostasis of the central nervous system and they are actively involved in shaping the brain's inflammatory response to stress. Among the multitude of involved molecules, purinergic receptors and enzymes are of special importance due to their ability to regulate microglia activation. By investigating the mechanisms underlying microglial responses and dysregulation, researchers can develop more precise interventions to modulate microglial behavior and alleviate neuroinflammatory processes. Studying gene function selectively in microglia, however, remains technically challenging. This review article provides an overview of adeno-associated virus (AAV)-based microglia targeting approaches, discussing potential prospects for refining these approaches to improve both specificity and effectiveness and encouraging future investigations aimed at connecting the potential of AAV-mediated microglial targeting for therapeutic benefit in neurological disorders.
KW - Dependovirus/genetics
KW - Humans
KW - Microglia/metabolism
KW - Genetic Vectors/genetics
KW - Animals
KW - Genetic Therapy/methods
U2 - 10.3389/fimmu.2024.1425892
DO - 10.3389/fimmu.2024.1425892
M3 - SCORING: Review article
C2 - 39035004
VL - 15
SP - 1425892
JO - FRONT IMMUNOL
JF - FRONT IMMUNOL
SN - 1664-3224
ER -