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Macrophage-tumor cell interaction promotes ATRT progression and chemoresistance

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Macrophage-tumor cell interaction promotes ATRT progression and chemoresistance. / Melcher, Viktoria; Graf, Monika; Interlandi, Marta; Moreno, Natalia; de Faria, Flavia W; Kim, Su Na; Kastrati, Dennis; Korbanka, Sonja; Alfert, Amelie; Gerß, Joachim; Meyer Zu Hörste, Gerd; Hartmann, Wolfgang; Frühwald, Michael C; Dugas, Martin; Schüller, Ulrich; Hasselblatt, Martin; Albert, Thomas K; Kerl, Kornelius.

in: ACTA NEUROPATHOL, Jahrgang 139, Nr. 5, 05.2020, S. 913-936.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Melcher, V, Graf, M, Interlandi, M, Moreno, N, de Faria, FW, Kim, SN, Kastrati, D, Korbanka, S, Alfert, A, Gerß, J, Meyer Zu Hörste, G, Hartmann, W, Frühwald, MC, Dugas, M, Schüller, U, Hasselblatt, M, Albert, TK & Kerl, K 2020, 'Macrophage-tumor cell interaction promotes ATRT progression and chemoresistance', ACTA NEUROPATHOL, Jg. 139, Nr. 5, S. 913-936. https://doi.org/10.1007/s00401-019-02116-7

APA

Melcher, V., Graf, M., Interlandi, M., Moreno, N., de Faria, F. W., Kim, S. N., Kastrati, D., Korbanka, S., Alfert, A., Gerß, J., Meyer Zu Hörste, G., Hartmann, W., Frühwald, M. C., Dugas, M., Schüller, U., Hasselblatt, M., Albert, T. K., & Kerl, K. (2020). Macrophage-tumor cell interaction promotes ATRT progression and chemoresistance. ACTA NEUROPATHOL, 139(5), 913-936. https://doi.org/10.1007/s00401-019-02116-7

Vancouver

Melcher V, Graf M, Interlandi M, Moreno N, de Faria FW, Kim SN et al. Macrophage-tumor cell interaction promotes ATRT progression and chemoresistance. ACTA NEUROPATHOL. 2020 Mai;139(5):913-936. https://doi.org/10.1007/s00401-019-02116-7

Bibtex

@article{ca3334a7f21a48689c602369947e5772,
title = "Macrophage-tumor cell interaction promotes ATRT progression and chemoresistance",
abstract = "Atypical teratoid/rhabdoid tumors (ATRT) are known for their heterogeneity concerning pathophysiology and outcome. However, predictive factors within distinct subgroups still need to be uncovered. Using multiplex immunofluorescent staining and single-cell RNA sequencing we unraveled distinct compositions of the immunological tumor microenvironment (TME) across ATRT subgroups. CD68+ cells predominantly infiltrate ATRT-SHH and ATRT-MYC and are a negative prognostic factor for patients' survival. Within the murine ATRT-MYC and ATRT-SHH TME, Cd68+ macrophages are core to intercellular communication with tumor cells. In ATRT-MYC distinct tumor cell phenotypes express macrophage marker genes. These cells are involved in the acquisition of chemotherapy resistance in our relapse xenograft mouse model. In conclusion, the tumor cell-macrophage interaction contributes to ATRT-MYC heterogeneity and potentially to tumor recurrence.",
author = "Viktoria Melcher and Monika Graf and Marta Interlandi and Natalia Moreno and {de Faria}, {Flavia W} and Kim, {Su Na} and Dennis Kastrati and Sonja Korbanka and Amelie Alfert and Joachim Ger{\ss} and {Meyer Zu H{\"o}rste}, Gerd and Wolfgang Hartmann and Fr{\"u}hwald, {Michael C} and Martin Dugas and Ulrich Sch{\"u}ller and Martin Hasselblatt and Albert, {Thomas K} and Kornelius Kerl",
year = "2020",
month = may,
doi = "10.1007/s00401-019-02116-7",
language = "English",
volume = "139",
pages = "913--936",
journal = "ACTA NEUROPATHOL",
issn = "0001-6322",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Macrophage-tumor cell interaction promotes ATRT progression and chemoresistance

AU - Melcher, Viktoria

AU - Graf, Monika

AU - Interlandi, Marta

AU - Moreno, Natalia

AU - de Faria, Flavia W

AU - Kim, Su Na

AU - Kastrati, Dennis

AU - Korbanka, Sonja

AU - Alfert, Amelie

AU - Gerß, Joachim

AU - Meyer Zu Hörste, Gerd

AU - Hartmann, Wolfgang

AU - Frühwald, Michael C

AU - Dugas, Martin

AU - Schüller, Ulrich

AU - Hasselblatt, Martin

AU - Albert, Thomas K

AU - Kerl, Kornelius

PY - 2020/5

Y1 - 2020/5

N2 - Atypical teratoid/rhabdoid tumors (ATRT) are known for their heterogeneity concerning pathophysiology and outcome. However, predictive factors within distinct subgroups still need to be uncovered. Using multiplex immunofluorescent staining and single-cell RNA sequencing we unraveled distinct compositions of the immunological tumor microenvironment (TME) across ATRT subgroups. CD68+ cells predominantly infiltrate ATRT-SHH and ATRT-MYC and are a negative prognostic factor for patients' survival. Within the murine ATRT-MYC and ATRT-SHH TME, Cd68+ macrophages are core to intercellular communication with tumor cells. In ATRT-MYC distinct tumor cell phenotypes express macrophage marker genes. These cells are involved in the acquisition of chemotherapy resistance in our relapse xenograft mouse model. In conclusion, the tumor cell-macrophage interaction contributes to ATRT-MYC heterogeneity and potentially to tumor recurrence.

AB - Atypical teratoid/rhabdoid tumors (ATRT) are known for their heterogeneity concerning pathophysiology and outcome. However, predictive factors within distinct subgroups still need to be uncovered. Using multiplex immunofluorescent staining and single-cell RNA sequencing we unraveled distinct compositions of the immunological tumor microenvironment (TME) across ATRT subgroups. CD68+ cells predominantly infiltrate ATRT-SHH and ATRT-MYC and are a negative prognostic factor for patients' survival. Within the murine ATRT-MYC and ATRT-SHH TME, Cd68+ macrophages are core to intercellular communication with tumor cells. In ATRT-MYC distinct tumor cell phenotypes express macrophage marker genes. These cells are involved in the acquisition of chemotherapy resistance in our relapse xenograft mouse model. In conclusion, the tumor cell-macrophage interaction contributes to ATRT-MYC heterogeneity and potentially to tumor recurrence.

U2 - 10.1007/s00401-019-02116-7

DO - 10.1007/s00401-019-02116-7

M3 - SCORING: Journal article

C2 - 31848709

VL - 139

SP - 913

EP - 936

JO - ACTA NEUROPATHOL

JF - ACTA NEUROPATHOL

SN - 0001-6322

IS - 5

ER -