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Low serum vitamin D level associated with incident advanced liver disease in the general population - a prospective study

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Low serum vitamin D level associated with incident advanced liver disease in the general population - a prospective study. / Männistö, Ville; Jääskeläinen, Tuija; Färkkilä, Martti; Jula, Antti; Männistö, Satu; Lundqvist, Annamari; Zeller, Tanja; Blankenberg, Stefan; Salomaa, Veikko; Perola, Markus; Åberg, Fredrik.

in: SCAND J GASTROENTERO, Jahrgang 56, Nr. 3, 03.2021, S. 299-303.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Männistö, V, Jääskeläinen, T, Färkkilä, M, Jula, A, Männistö, S, Lundqvist, A, Zeller, T, Blankenberg, S, Salomaa, V, Perola, M & Åberg, F 2021, 'Low serum vitamin D level associated with incident advanced liver disease in the general population - a prospective study', SCAND J GASTROENTERO, Jg. 56, Nr. 3, S. 299-303. https://doi.org/10.1080/00365521.2021.1873412

APA

Männistö, V., Jääskeläinen, T., Färkkilä, M., Jula, A., Männistö, S., Lundqvist, A., Zeller, T., Blankenberg, S., Salomaa, V., Perola, M., & Åberg, F. (2021). Low serum vitamin D level associated with incident advanced liver disease in the general population - a prospective study. SCAND J GASTROENTERO, 56(3), 299-303. https://doi.org/10.1080/00365521.2021.1873412

Vancouver

Männistö V, Jääskeläinen T, Färkkilä M, Jula A, Männistö S, Lundqvist A et al. Low serum vitamin D level associated with incident advanced liver disease in the general population - a prospective study. SCAND J GASTROENTERO. 2021 Mär;56(3):299-303. https://doi.org/10.1080/00365521.2021.1873412

Bibtex

@article{f0058cd91d3e48108aaaafe46bfba9a5,
title = "Low serum vitamin D level associated with incident advanced liver disease in the general population - a prospective study",
abstract = "BACKGROUND: Vitamin D deficiency is a common finding in chronic liver disease. It has also been linked to the pathogenesis of non-alcoholic fatty liver disease, hepatic fibrogenesis, decompensation and hepatocellular carcinoma.AIMS: We analyzed whether serum vitamin D is associated with incident advanced liver disease in the general population.METHODS: Serum 25-hydroxyvitamin D was measured in 13807 individuals participating in the Finnish population-based health examination surveys FINRISK 1997 and Health 2000. Data were linked with incident advanced liver disease (hospitalization, cancer or death related to liver disease). During a follow-up of 201444 person-years 148 severe liver events occurred. Analyses were performed using multivariable Cox regression analyses.RESULTS: Vitamin D level associated with incident advanced liver disease with the hazard ratio of 0.972 (95% confidence interval 0.943-0.976, p < .001), when adjusted for age, sex, blood sampling season and stratified by cohort.The association remained robust and significant in multiple different adjustment models adjusting sequentially for 22 potential confounders.CONCLUSION: Low vitamin D level is linked to incident advanced liver disease at population level.",
keywords = "Humans, Liver Neoplasms/epidemiology, Non-alcoholic Fatty Liver Disease, Prospective Studies, Risk Factors, Vitamin D, Vitamin D Deficiency/complications",
author = "Ville M{\"a}nnist{\"o} and Tuija J{\"a}{\"a}skel{\"a}inen and Martti F{\"a}rkkil{\"a} and Antti Jula and Satu M{\"a}nnist{\"o} and Annamari Lundqvist and Tanja Zeller and Stefan Blankenberg and Veikko Salomaa and Markus Perola and Fredrik {\AA}berg",
year = "2021",
month = mar,
doi = "10.1080/00365521.2021.1873412",
language = "English",
volume = "56",
pages = "299--303",
journal = "SCAND J GASTROENTERO",
issn = "0036-5521",
publisher = "informa healthcare",
number = "3",

}

RIS

TY - JOUR

T1 - Low serum vitamin D level associated with incident advanced liver disease in the general population - a prospective study

AU - Männistö, Ville

AU - Jääskeläinen, Tuija

AU - Färkkilä, Martti

AU - Jula, Antti

AU - Männistö, Satu

AU - Lundqvist, Annamari

AU - Zeller, Tanja

AU - Blankenberg, Stefan

AU - Salomaa, Veikko

AU - Perola, Markus

AU - Åberg, Fredrik

PY - 2021/3

Y1 - 2021/3

N2 - BACKGROUND: Vitamin D deficiency is a common finding in chronic liver disease. It has also been linked to the pathogenesis of non-alcoholic fatty liver disease, hepatic fibrogenesis, decompensation and hepatocellular carcinoma.AIMS: We analyzed whether serum vitamin D is associated with incident advanced liver disease in the general population.METHODS: Serum 25-hydroxyvitamin D was measured in 13807 individuals participating in the Finnish population-based health examination surveys FINRISK 1997 and Health 2000. Data were linked with incident advanced liver disease (hospitalization, cancer or death related to liver disease). During a follow-up of 201444 person-years 148 severe liver events occurred. Analyses were performed using multivariable Cox regression analyses.RESULTS: Vitamin D level associated with incident advanced liver disease with the hazard ratio of 0.972 (95% confidence interval 0.943-0.976, p < .001), when adjusted for age, sex, blood sampling season and stratified by cohort.The association remained robust and significant in multiple different adjustment models adjusting sequentially for 22 potential confounders.CONCLUSION: Low vitamin D level is linked to incident advanced liver disease at population level.

AB - BACKGROUND: Vitamin D deficiency is a common finding in chronic liver disease. It has also been linked to the pathogenesis of non-alcoholic fatty liver disease, hepatic fibrogenesis, decompensation and hepatocellular carcinoma.AIMS: We analyzed whether serum vitamin D is associated with incident advanced liver disease in the general population.METHODS: Serum 25-hydroxyvitamin D was measured in 13807 individuals participating in the Finnish population-based health examination surveys FINRISK 1997 and Health 2000. Data were linked with incident advanced liver disease (hospitalization, cancer or death related to liver disease). During a follow-up of 201444 person-years 148 severe liver events occurred. Analyses were performed using multivariable Cox regression analyses.RESULTS: Vitamin D level associated with incident advanced liver disease with the hazard ratio of 0.972 (95% confidence interval 0.943-0.976, p < .001), when adjusted for age, sex, blood sampling season and stratified by cohort.The association remained robust and significant in multiple different adjustment models adjusting sequentially for 22 potential confounders.CONCLUSION: Low vitamin D level is linked to incident advanced liver disease at population level.

KW - Humans

KW - Liver Neoplasms/epidemiology

KW - Non-alcoholic Fatty Liver Disease

KW - Prospective Studies

KW - Risk Factors

KW - Vitamin D

KW - Vitamin D Deficiency/complications

U2 - 10.1080/00365521.2021.1873412

DO - 10.1080/00365521.2021.1873412

M3 - SCORING: Journal article

C2 - 33478287

VL - 56

SP - 299

EP - 303

JO - SCAND J GASTROENTERO

JF - SCAND J GASTROENTERO

SN - 0036-5521

IS - 3

ER -