Low serum vitamin D level associated with incident advanced liver disease in the general population - a prospective study
Beteiligte Einrichtungen
Abstract
BACKGROUND: Vitamin D deficiency is a common finding in chronic liver disease. It has also been linked to the pathogenesis of non-alcoholic fatty liver disease, hepatic fibrogenesis, decompensation and hepatocellular carcinoma.
AIMS: We analyzed whether serum vitamin D is associated with incident advanced liver disease in the general population.
METHODS: Serum 25-hydroxyvitamin D was measured in 13807 individuals participating in the Finnish population-based health examination surveys FINRISK 1997 and Health 2000. Data were linked with incident advanced liver disease (hospitalization, cancer or death related to liver disease). During a follow-up of 201444 person-years 148 severe liver events occurred. Analyses were performed using multivariable Cox regression analyses.
RESULTS: Vitamin D level associated with incident advanced liver disease with the hazard ratio of 0.972 (95% confidence interval 0.943-0.976, p < .001), when adjusted for age, sex, blood sampling season and stratified by cohort.The association remained robust and significant in multiple different adjustment models adjusting sequentially for 22 potential confounders.
CONCLUSION: Low vitamin D level is linked to incident advanced liver disease at population level.
Bibliografische Daten
Originalsprache | Englisch |
---|---|
ISSN | 0036-5521 |
DOIs | |
Status | Veröffentlicht - 03.2021 |
PubMed | 33478287 |
---|