Low serum vitamin D level associated with incident advanced liver disease in the general population - a prospective study
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Low serum vitamin D level associated with incident advanced liver disease in the general population - a prospective study. / Männistö, Ville; Jääskeläinen, Tuija; Färkkilä, Martti; Jula, Antti; Männistö, Satu; Lundqvist, Annamari; Zeller, Tanja; Blankenberg, Stefan; Salomaa, Veikko; Perola, Markus; Åberg, Fredrik.
In: SCAND J GASTROENTERO, Vol. 56, No. 3, 03.2021, p. 299-303.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Low serum vitamin D level associated with incident advanced liver disease in the general population - a prospective study
AU - Männistö, Ville
AU - Jääskeläinen, Tuija
AU - Färkkilä, Martti
AU - Jula, Antti
AU - Männistö, Satu
AU - Lundqvist, Annamari
AU - Zeller, Tanja
AU - Blankenberg, Stefan
AU - Salomaa, Veikko
AU - Perola, Markus
AU - Åberg, Fredrik
PY - 2021/3
Y1 - 2021/3
N2 - BACKGROUND: Vitamin D deficiency is a common finding in chronic liver disease. It has also been linked to the pathogenesis of non-alcoholic fatty liver disease, hepatic fibrogenesis, decompensation and hepatocellular carcinoma.AIMS: We analyzed whether serum vitamin D is associated with incident advanced liver disease in the general population.METHODS: Serum 25-hydroxyvitamin D was measured in 13807 individuals participating in the Finnish population-based health examination surveys FINRISK 1997 and Health 2000. Data were linked with incident advanced liver disease (hospitalization, cancer or death related to liver disease). During a follow-up of 201444 person-years 148 severe liver events occurred. Analyses were performed using multivariable Cox regression analyses.RESULTS: Vitamin D level associated with incident advanced liver disease with the hazard ratio of 0.972 (95% confidence interval 0.943-0.976, p < .001), when adjusted for age, sex, blood sampling season and stratified by cohort.The association remained robust and significant in multiple different adjustment models adjusting sequentially for 22 potential confounders.CONCLUSION: Low vitamin D level is linked to incident advanced liver disease at population level.
AB - BACKGROUND: Vitamin D deficiency is a common finding in chronic liver disease. It has also been linked to the pathogenesis of non-alcoholic fatty liver disease, hepatic fibrogenesis, decompensation and hepatocellular carcinoma.AIMS: We analyzed whether serum vitamin D is associated with incident advanced liver disease in the general population.METHODS: Serum 25-hydroxyvitamin D was measured in 13807 individuals participating in the Finnish population-based health examination surveys FINRISK 1997 and Health 2000. Data were linked with incident advanced liver disease (hospitalization, cancer or death related to liver disease). During a follow-up of 201444 person-years 148 severe liver events occurred. Analyses were performed using multivariable Cox regression analyses.RESULTS: Vitamin D level associated with incident advanced liver disease with the hazard ratio of 0.972 (95% confidence interval 0.943-0.976, p < .001), when adjusted for age, sex, blood sampling season and stratified by cohort.The association remained robust and significant in multiple different adjustment models adjusting sequentially for 22 potential confounders.CONCLUSION: Low vitamin D level is linked to incident advanced liver disease at population level.
KW - Humans
KW - Liver Neoplasms/epidemiology
KW - Non-alcoholic Fatty Liver Disease
KW - Prospective Studies
KW - Risk Factors
KW - Vitamin D
KW - Vitamin D Deficiency/complications
U2 - 10.1080/00365521.2021.1873412
DO - 10.1080/00365521.2021.1873412
M3 - SCORING: Journal article
C2 - 33478287
VL - 56
SP - 299
EP - 303
JO - SCAND J GASTROENTERO
JF - SCAND J GASTROENTERO
SN - 0036-5521
IS - 3
ER -