Liver transplantation as a potentially lifesaving measure in neuroblastoma stage 4S
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Liver transplantation as a potentially lifesaving measure in neuroblastoma stage 4S. / Holsten, Till; Schuster, Tobias; Grabhorn, Enke; Hero, Barbara; Frühwald, Michael C.
in: PEDIATR HEMAT ONCOL, Jahrgang 34, Nr. 1, 02.2017, S. 17-23.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Liver transplantation as a potentially lifesaving measure in neuroblastoma stage 4S
AU - Holsten, Till
AU - Schuster, Tobias
AU - Grabhorn, Enke
AU - Hero, Barbara
AU - Frühwald, Michael C
PY - 2017/2
Y1 - 2017/2
N2 - Neuroblastoma (NBL) stage 4s is an incompletely understood phenomenon with variable clinical course. While the majority of patients may undergo spontaneous regression and achieve complete resolution without intensive therapy, a small proportion is at increased risk of developing secondary complications. One such situation is liver insufficiency due to diffuse metastases. We report a patient suffering from NBL 4S who required double lifesaving liver transplantation. Abdominal and respiratory complications due to hepatomegaly are crucial determinants for treatment intensity and duration in 4S NBL [1,2] . We provide an algorithm in order to facilitate the clinical decision when dealing with similar potentially life-threatening events.
AB - Neuroblastoma (NBL) stage 4s is an incompletely understood phenomenon with variable clinical course. While the majority of patients may undergo spontaneous regression and achieve complete resolution without intensive therapy, a small proportion is at increased risk of developing secondary complications. One such situation is liver insufficiency due to diffuse metastases. We report a patient suffering from NBL 4S who required double lifesaving liver transplantation. Abdominal and respiratory complications due to hepatomegaly are crucial determinants for treatment intensity and duration in 4S NBL [1,2] . We provide an algorithm in order to facilitate the clinical decision when dealing with similar potentially life-threatening events.
U2 - 10.1080/08880018.2016.1266535
DO - 10.1080/08880018.2016.1266535
M3 - SCORING: Journal article
C2 - 28085536
VL - 34
SP - 17
EP - 23
JO - PEDIATR HEMAT ONCOL
JF - PEDIATR HEMAT ONCOL
SN - 0888-0018
IS - 1
ER -