Liver transplantation as a potentially lifesaving measure in neuroblastoma stage 4S

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Liver transplantation as a potentially lifesaving measure in neuroblastoma stage 4S. / Holsten, Till; Schuster, Tobias; Grabhorn, Enke; Hero, Barbara; Frühwald, Michael C.

In: PEDIATR HEMAT ONCOL, Vol. 34, No. 1, 02.2017, p. 17-23.

Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

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@article{a8b73d0494ed40d6a1947c7f04f486bc,
title = "Liver transplantation as a potentially lifesaving measure in neuroblastoma stage 4S",
abstract = "Neuroblastoma (NBL) stage 4s is an incompletely understood phenomenon with variable clinical course. While the majority of patients may undergo spontaneous regression and achieve complete resolution without intensive therapy, a small proportion is at increased risk of developing secondary complications. One such situation is liver insufficiency due to diffuse metastases. We report a patient suffering from NBL 4S who required double lifesaving liver transplantation. Abdominal and respiratory complications due to hepatomegaly are crucial determinants for treatment intensity and duration in 4S NBL [1,2] . We provide an algorithm in order to facilitate the clinical decision when dealing with similar potentially life-threatening events.",
author = "Till Holsten and Tobias Schuster and Enke Grabhorn and Barbara Hero and Fr{\"u}hwald, {Michael C}",
year = "2017",
month = feb,
doi = "10.1080/08880018.2016.1266535",
language = "English",
volume = "34",
pages = "17--23",
journal = "PEDIATR HEMAT ONCOL",
issn = "0888-0018",
publisher = "informa healthcare",
number = "1",

}

RIS

TY - JOUR

T1 - Liver transplantation as a potentially lifesaving measure in neuroblastoma stage 4S

AU - Holsten, Till

AU - Schuster, Tobias

AU - Grabhorn, Enke

AU - Hero, Barbara

AU - Frühwald, Michael C

PY - 2017/2

Y1 - 2017/2

N2 - Neuroblastoma (NBL) stage 4s is an incompletely understood phenomenon with variable clinical course. While the majority of patients may undergo spontaneous regression and achieve complete resolution without intensive therapy, a small proportion is at increased risk of developing secondary complications. One such situation is liver insufficiency due to diffuse metastases. We report a patient suffering from NBL 4S who required double lifesaving liver transplantation. Abdominal and respiratory complications due to hepatomegaly are crucial determinants for treatment intensity and duration in 4S NBL [1,2] . We provide an algorithm in order to facilitate the clinical decision when dealing with similar potentially life-threatening events.

AB - Neuroblastoma (NBL) stage 4s is an incompletely understood phenomenon with variable clinical course. While the majority of patients may undergo spontaneous regression and achieve complete resolution without intensive therapy, a small proportion is at increased risk of developing secondary complications. One such situation is liver insufficiency due to diffuse metastases. We report a patient suffering from NBL 4S who required double lifesaving liver transplantation. Abdominal and respiratory complications due to hepatomegaly are crucial determinants for treatment intensity and duration in 4S NBL [1,2] . We provide an algorithm in order to facilitate the clinical decision when dealing with similar potentially life-threatening events.

U2 - 10.1080/08880018.2016.1266535

DO - 10.1080/08880018.2016.1266535

M3 - SCORING: Journal article

C2 - 28085536

VL - 34

SP - 17

EP - 23

JO - PEDIATR HEMAT ONCOL

JF - PEDIATR HEMAT ONCOL

SN - 0888-0018

IS - 1

ER -