Kallikrein-kinin activation by altered vitreous pH
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TY - JOUR
T1 - Kallikrein-kinin activation by altered vitreous pH
T2 - New perspectives for treatment and pathogenesis of diabetic macular edema? : Comment on: Gao BB et al. Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation. Nat Med. 2007 Feb;13(2):181-8
AU - Zeitz, O
AU - Keserü, M
PY - 2007/12/1
Y1 - 2007/12/1
N2 - Recently, Gao et al. published an experimental study based on the pathophysiology of diabetic macular edema in Nature Medicine (Nat Med. 2007 Feb;13(2):181-8). They found an increased amount of carbonic anhydrase in the vitreous, which causes a pH shift. This activates the kallikrein-kinin system and leads to increased retinal vascular permeability. In this comment the clinical implications of this article are discussed.
AB - Recently, Gao et al. published an experimental study based on the pathophysiology of diabetic macular edema in Nature Medicine (Nat Med. 2007 Feb;13(2):181-8). They found an increased amount of carbonic anhydrase in the vitreous, which causes a pH shift. This activates the kallikrein-kinin system and leads to increased retinal vascular permeability. In this comment the clinical implications of this article are discussed.
KW - Capillary Permeability
KW - Carbonic Anhydrases
KW - Diabetic Retinopathy
KW - Humans
KW - Hydrogen-Ion Concentration
KW - Kallikrein-Kinin System
KW - Macular Edema
KW - Retinal Vessels
KW - Vitreous Body
U2 - 10.1007/s00417-007-0673-7
DO - 10.1007/s00417-007-0673-7
M3 - SCORING: Journal article
C2 - 17823811
VL - 245
SP - 1745
EP - 1747
JO - GRAEF ARCH CLIN EXP
JF - GRAEF ARCH CLIN EXP
SN - 0721-832X
IS - 12
ER -