Kallikrein-kinin activation by altered vitreous pH
Beteiligte Einrichtungen
Abstract
Recently, Gao et al. published an experimental study based on the pathophysiology of diabetic macular edema in Nature Medicine (Nat Med. 2007 Feb;13(2):181-8). They found an increased amount of carbonic anhydrase in the vitreous, which causes a pH shift. This activates the kallikrein-kinin system and leads to increased retinal vascular permeability. In this comment the clinical implications of this article are discussed.
Bibliografische Daten
Originalsprache | Englisch |
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ISSN | 0721-832X |
DOIs | |
Status | Veröffentlicht - 01.12.2007 |
PubMed | 17823811 |
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