Isoprostanes and neuroprostanes: total synthesis, biological activity and biomarkers of oxidative stress in humans
Beteiligte Einrichtungen
Abstract
Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans.
Bibliografische Daten
Originalsprache | Englisch |
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ISSN | 1098-8823 |
DOIs | |
Status | Veröffentlicht - 01.12.2013 |
PubMed | 23644158 |
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