Isoprostanes and neuroprostanes: total synthesis, biological activity and biomarkers of oxidative stress in humans

Jean-Marie Galano; Emilie Mas; Anne Barden; Trevor A Mori; Cinzia Signorini; Claudio De Felice; Aaron Barrett; Catherine Opere; Edith Pinot; Edzard Schwedhelm; Ralf Benndorf; Jérôme Roy; Jean-Yves Le Guennec; Camille Oger; Thierry Durand

doi:10.1016/j.prostaglandins.2013.04.003

Isoprostanes and neuroprostanes: total synthesis, biological activity and biomarkers of oxidative stress in humans

Jean-Marie Galano
Emilie Mas
Anne Barden
Trevor A Mori
Cinzia Signorini
Claudio De Felice
Aaron Barrett
Catherine Opere
Edith Pinot
Edzard Schwedhelm
Ralf Benndorf
Jérôme Roy
Jean-Yves Le Guennec
Camille Oger
Thierry Durand

Related Research units

Institute of Clinical Pharmacology and Toxicology

Abstract

Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans.

Bibliographical data

Original language	English
ISSN	1098-8823
DOIs	https://doi.org/10.1016/j.prostaglandins.2013.04.003
Publication status	Published - 01.12.2013

PubMed	23644158