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Involvement of astrocyte and oligodendrocyte gene sets in migraine

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Involvement of astrocyte and oligodendrocyte gene sets in migraine. / Eising, Else; de Leeuw, Christiaan; Min, Josine L; Anttila, Verneri; Verheijen, Mark Hg; Terwindt, Gisela M; Dichgans, Martin; Freilinger, Tobias; Kubisch, Christian; Ferrari, Michel D; Smit, August B; de Vries, Boukje; Palotie, Aarno; van den Maagdenberg, Arn Mjm; Posthuma, Danielle; International Headache Genetics Consortium.

in: CEPHALALGIA, Jahrgang 36, Nr. 7, 01.06.2016, S. 640-7.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Eising, E, de Leeuw, C, Min, JL, Anttila, V, Verheijen, MH, Terwindt, GM, Dichgans, M, Freilinger, T, Kubisch, C, Ferrari, MD, Smit, AB, de Vries, B, Palotie, A, van den Maagdenberg, AM, Posthuma, D & International Headache Genetics Consortium 2016, 'Involvement of astrocyte and oligodendrocyte gene sets in migraine', CEPHALALGIA, Jg. 36, Nr. 7, S. 640-7. https://doi.org/10.1177/0333102415618614

APA

Eising, E., de Leeuw, C., Min, J. L., Anttila, V., Verheijen, M. H., Terwindt, G. M., Dichgans, M., Freilinger, T., Kubisch, C., Ferrari, M. D., Smit, A. B., de Vries, B., Palotie, A., van den Maagdenberg, A. M., Posthuma, D., & International Headache Genetics Consortium (2016). Involvement of astrocyte and oligodendrocyte gene sets in migraine. CEPHALALGIA, 36(7), 640-7. https://doi.org/10.1177/0333102415618614

Vancouver

Eising E, de Leeuw C, Min JL, Anttila V, Verheijen MH, Terwindt GM et al. Involvement of astrocyte and oligodendrocyte gene sets in migraine. CEPHALALGIA. 2016 Jun 1;36(7):640-7. https://doi.org/10.1177/0333102415618614

Bibtex

@article{845f178397624112aa8ad408fe76d94c,
title = "Involvement of astrocyte and oligodendrocyte gene sets in migraine",
abstract = "BACKGROUND: E.E. and C.d.L. contributed equally to this work. A.M.J.M.v.d.M. and D.P. jointly directed this work.Migraine is a common episodic brain disorder characterized by recurrent attacks of severe unilateral headache and additional neurological symptoms. Two main migraine types can be distinguished based on the presence of aura symptoms that can accompany the headache: migraine with aura and migraine without aura. Multiple genetic and environmental factors confer disease susceptibility. Recent genome-wide association studies (GWAS) indicate that migraine susceptibility genes are involved in various pathways, including neurotransmission, which have already been implicated in genetic studies of monogenic familial hemiplegic migraine, a subtype of migraine with aura.METHODS: To further explore the genetic background of migraine, we performed a gene set analysis of migraine GWAS data of 4954 clinic-based patients with migraine, as well as 13,390 controls. Curated sets of synaptic genes and sets of genes predominantly expressed in three glial cell types (astrocytes, microglia and oligodendrocytes) were investigated.DISCUSSION: Our results show that gene sets containing astrocyte- and oligodendrocyte-related genes are associated with migraine, which is especially true for gene sets involved in protein modification and signal transduction. Observed differences between migraine with aura and migraine without aura indicate that both migraine types, at least in part, seem to have a different genetic background.",
author = "Else Eising and {de Leeuw}, Christiaan and Min, {Josine L} and Verneri Anttila and Verheijen, {Mark Hg} and Terwindt, {Gisela M} and Martin Dichgans and Tobias Freilinger and Christian Kubisch and Ferrari, {Michel D} and Smit, {August B} and {de Vries}, Boukje and Aarno Palotie and {van den Maagdenberg}, {Arn Mjm} and Danielle Posthuma and {International Headache Genetics Consortium}",
note = "{\textcopyright} International Headache Society 2015.",
year = "2016",
month = jun,
day = "1",
doi = "10.1177/0333102415618614",
language = "English",
volume = "36",
pages = "640--7",
journal = "CEPHALALGIA",
issn = "0333-1024",
publisher = "SAGE Publications",
number = "7",

}

RIS

TY - JOUR

T1 - Involvement of astrocyte and oligodendrocyte gene sets in migraine

AU - Eising, Else

AU - de Leeuw, Christiaan

AU - Min, Josine L

AU - Anttila, Verneri

AU - Verheijen, Mark Hg

AU - Terwindt, Gisela M

AU - Dichgans, Martin

AU - Freilinger, Tobias

AU - Kubisch, Christian

AU - Ferrari, Michel D

AU - Smit, August B

AU - de Vries, Boukje

AU - Palotie, Aarno

AU - van den Maagdenberg, Arn Mjm

AU - Posthuma, Danielle

AU - International Headache Genetics Consortium

N1 - © International Headache Society 2015.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - BACKGROUND: E.E. and C.d.L. contributed equally to this work. A.M.J.M.v.d.M. and D.P. jointly directed this work.Migraine is a common episodic brain disorder characterized by recurrent attacks of severe unilateral headache and additional neurological symptoms. Two main migraine types can be distinguished based on the presence of aura symptoms that can accompany the headache: migraine with aura and migraine without aura. Multiple genetic and environmental factors confer disease susceptibility. Recent genome-wide association studies (GWAS) indicate that migraine susceptibility genes are involved in various pathways, including neurotransmission, which have already been implicated in genetic studies of monogenic familial hemiplegic migraine, a subtype of migraine with aura.METHODS: To further explore the genetic background of migraine, we performed a gene set analysis of migraine GWAS data of 4954 clinic-based patients with migraine, as well as 13,390 controls. Curated sets of synaptic genes and sets of genes predominantly expressed in three glial cell types (astrocytes, microglia and oligodendrocytes) were investigated.DISCUSSION: Our results show that gene sets containing astrocyte- and oligodendrocyte-related genes are associated with migraine, which is especially true for gene sets involved in protein modification and signal transduction. Observed differences between migraine with aura and migraine without aura indicate that both migraine types, at least in part, seem to have a different genetic background.

AB - BACKGROUND: E.E. and C.d.L. contributed equally to this work. A.M.J.M.v.d.M. and D.P. jointly directed this work.Migraine is a common episodic brain disorder characterized by recurrent attacks of severe unilateral headache and additional neurological symptoms. Two main migraine types can be distinguished based on the presence of aura symptoms that can accompany the headache: migraine with aura and migraine without aura. Multiple genetic and environmental factors confer disease susceptibility. Recent genome-wide association studies (GWAS) indicate that migraine susceptibility genes are involved in various pathways, including neurotransmission, which have already been implicated in genetic studies of monogenic familial hemiplegic migraine, a subtype of migraine with aura.METHODS: To further explore the genetic background of migraine, we performed a gene set analysis of migraine GWAS data of 4954 clinic-based patients with migraine, as well as 13,390 controls. Curated sets of synaptic genes and sets of genes predominantly expressed in three glial cell types (astrocytes, microglia and oligodendrocytes) were investigated.DISCUSSION: Our results show that gene sets containing astrocyte- and oligodendrocyte-related genes are associated with migraine, which is especially true for gene sets involved in protein modification and signal transduction. Observed differences between migraine with aura and migraine without aura indicate that both migraine types, at least in part, seem to have a different genetic background.

U2 - 10.1177/0333102415618614

DO - 10.1177/0333102415618614

M3 - SCORING: Journal article

C2 - 26646788

VL - 36

SP - 640

EP - 647

JO - CEPHALALGIA

JF - CEPHALALGIA

SN - 0333-1024

IS - 7

ER -