Involvement of astrocyte and oligodendrocyte gene sets in migraine
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Involvement of astrocyte and oligodendrocyte gene sets in migraine. / Eising, Else; de Leeuw, Christiaan; Min, Josine L; Anttila, Verneri; Verheijen, Mark Hg; Terwindt, Gisela M; Dichgans, Martin; Freilinger, Tobias; Kubisch, Christian; Ferrari, Michel D; Smit, August B; de Vries, Boukje; Palotie, Aarno; van den Maagdenberg, Arn Mjm; Posthuma, Danielle; International Headache Genetics Consortium.
In: CEPHALALGIA, Vol. 36, No. 7, 01.06.2016, p. 640-7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Involvement of astrocyte and oligodendrocyte gene sets in migraine
AU - Eising, Else
AU - de Leeuw, Christiaan
AU - Min, Josine L
AU - Anttila, Verneri
AU - Verheijen, Mark Hg
AU - Terwindt, Gisela M
AU - Dichgans, Martin
AU - Freilinger, Tobias
AU - Kubisch, Christian
AU - Ferrari, Michel D
AU - Smit, August B
AU - de Vries, Boukje
AU - Palotie, Aarno
AU - van den Maagdenberg, Arn Mjm
AU - Posthuma, Danielle
AU - International Headache Genetics Consortium
N1 - © International Headache Society 2015.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - BACKGROUND: E.E. and C.d.L. contributed equally to this work. A.M.J.M.v.d.M. and D.P. jointly directed this work.Migraine is a common episodic brain disorder characterized by recurrent attacks of severe unilateral headache and additional neurological symptoms. Two main migraine types can be distinguished based on the presence of aura symptoms that can accompany the headache: migraine with aura and migraine without aura. Multiple genetic and environmental factors confer disease susceptibility. Recent genome-wide association studies (GWAS) indicate that migraine susceptibility genes are involved in various pathways, including neurotransmission, which have already been implicated in genetic studies of monogenic familial hemiplegic migraine, a subtype of migraine with aura.METHODS: To further explore the genetic background of migraine, we performed a gene set analysis of migraine GWAS data of 4954 clinic-based patients with migraine, as well as 13,390 controls. Curated sets of synaptic genes and sets of genes predominantly expressed in three glial cell types (astrocytes, microglia and oligodendrocytes) were investigated.DISCUSSION: Our results show that gene sets containing astrocyte- and oligodendrocyte-related genes are associated with migraine, which is especially true for gene sets involved in protein modification and signal transduction. Observed differences between migraine with aura and migraine without aura indicate that both migraine types, at least in part, seem to have a different genetic background.
AB - BACKGROUND: E.E. and C.d.L. contributed equally to this work. A.M.J.M.v.d.M. and D.P. jointly directed this work.Migraine is a common episodic brain disorder characterized by recurrent attacks of severe unilateral headache and additional neurological symptoms. Two main migraine types can be distinguished based on the presence of aura symptoms that can accompany the headache: migraine with aura and migraine without aura. Multiple genetic and environmental factors confer disease susceptibility. Recent genome-wide association studies (GWAS) indicate that migraine susceptibility genes are involved in various pathways, including neurotransmission, which have already been implicated in genetic studies of monogenic familial hemiplegic migraine, a subtype of migraine with aura.METHODS: To further explore the genetic background of migraine, we performed a gene set analysis of migraine GWAS data of 4954 clinic-based patients with migraine, as well as 13,390 controls. Curated sets of synaptic genes and sets of genes predominantly expressed in three glial cell types (astrocytes, microglia and oligodendrocytes) were investigated.DISCUSSION: Our results show that gene sets containing astrocyte- and oligodendrocyte-related genes are associated with migraine, which is especially true for gene sets involved in protein modification and signal transduction. Observed differences between migraine with aura and migraine without aura indicate that both migraine types, at least in part, seem to have a different genetic background.
U2 - 10.1177/0333102415618614
DO - 10.1177/0333102415618614
M3 - SCORING: Journal article
C2 - 26646788
VL - 36
SP - 640
EP - 647
JO - CEPHALALGIA
JF - CEPHALALGIA
SN - 0333-1024
IS - 7
ER -