Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A.

  • S Küsters
  • F Gantner
  • G Künstle
  • Gisa Tiegs

Abstract

T cell-dependent liver injury involving endogenous tumor necrosis factor (TNF) alpha can be induced by either concanavalin A in naive mice or by activating anti-CD3 antibody or staphylococcal enterotoxin B in D-galactosamine-sensitized mice. In this study, the role of interferon gamma (IFN-gamma) in these T-cell models was addressed.

Bibliografische Daten

OriginalspracheEnglisch
Aufsatznummer2
ISSN0016-5085
StatusVeröffentlicht - 1996
pubmed 8690213