Insufficient sensitivity of laser desorption-time of flight mass spectrometry-based detection of hemozoin for malaria screening

Martin Christner; Hagen Frickmann; Eva Klupp; Holger Rohde; Maya Kono; Egbert Tannich; Sven Poppert

doi:10.1016/j.mimet.2019.04.002

Insufficient sensitivity of laser desorption-time of flight mass spectrometry-based detection of hemozoin for malaria screening

Martin Christner (Geteilte/r Erstautor/in)
Hagen Frickmann (Geteilte/r Erstautor/in)
Eva Klupp
Holger Rohde
Maya Kono
Egbert Tannich
Sven Poppert

Beteiligte Einrichtungen

Institut für Medizinische Mikrobiologie, Virologie und Hygiene

Abstract

Laser desorption-time of flight (LD-TOF) mass spectrometry-based detection of hemozoin was assessed for its performance characteristics as a rapid screening test for malaria. In spite of good specificity of > 95%, poor sensitivity of 80.2% for microscopically positive samples makes the easy-to-apply and rapid approach unsuitable for the routine diagnostic setting.

Bibliografische Daten

Originalsprache	Englisch
ISSN	0167-7012
DOIs	https://doi.org/10.1016/j.mimet.2019.04.002
Status	Veröffentlicht - 05.2019

Anmerkungen des Dekanats

PubMed	30953660