Insufficient sensitivity of laser desorption-time of flight mass spectrometry-based detection of hemozoin for malaria screening

Martin Christner; Hagen Frickmann; Eva Klupp; Holger Rohde; Maya Kono; Egbert Tannich; Sven Poppert

doi:10.1016/j.mimet.2019.04.002

Insufficient sensitivity of laser desorption-time of flight mass spectrometry-based detection of hemozoin for malaria screening

Martin Christner (Shared first author)
Hagen Frickmann (Shared first author)
Eva Klupp
Holger Rohde
Maya Kono
Egbert Tannich
Sven Poppert

Related Research units

Institute of Medical Microbiology, Virology and Hygiene

Abstract

Laser desorption-time of flight (LD-TOF) mass spectrometry-based detection of hemozoin was assessed for its performance characteristics as a rapid screening test for malaria. In spite of good specificity of >95%, poor sensitivity of 80.2% for microscopically positive samples makes the easy-to-apply and rapid approach unsuitable for the routine diagnostic setting.

Bibliographical data

Original language	English
ISSN	0167-7012
DOIs	https://doi.org/10.1016/j.mimet.2019.04.002
Publication status	Published - 05.2019

PubMed	30953660