Insufficient sensitivity of laser desorption-time of flight mass spectrometry-based detection of hemozoin for malaria screening
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Insufficient sensitivity of laser desorption-time of flight mass spectrometry-based detection of hemozoin for malaria screening. / Christner, Martin; Frickmann, Hagen; Klupp, Eva; Rohde, Holger; Kono, Maya; Tannich, Egbert; Poppert, Sven.
in: J MICROBIOL METH, Jahrgang 160, 05.2019, S. 104-106.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Insufficient sensitivity of laser desorption-time of flight mass spectrometry-based detection of hemozoin for malaria screening
AU - Christner, Martin
AU - Frickmann, Hagen
AU - Klupp, Eva
AU - Rohde, Holger
AU - Kono, Maya
AU - Tannich, Egbert
AU - Poppert, Sven
N1 - Copyright © 2019 Elsevier B.V. All rights reserved.
PY - 2019/5
Y1 - 2019/5
N2 - Laser desorption-time of flight (LD-TOF) mass spectrometry-based detection of hemozoin was assessed for its performance characteristics as a rapid screening test for malaria. In spite of good specificity of >95%, poor sensitivity of 80.2% for microscopically positive samples makes the easy-to-apply and rapid approach unsuitable for the routine diagnostic setting.
AB - Laser desorption-time of flight (LD-TOF) mass spectrometry-based detection of hemozoin was assessed for its performance characteristics as a rapid screening test for malaria. In spite of good specificity of >95%, poor sensitivity of 80.2% for microscopically positive samples makes the easy-to-apply and rapid approach unsuitable for the routine diagnostic setting.
U2 - 10.1016/j.mimet.2019.04.002
DO - 10.1016/j.mimet.2019.04.002
M3 - SCORING: Journal article
C2 - 30953660
VL - 160
SP - 104
EP - 106
JO - J MICROBIOL METH
JF - J MICROBIOL METH
SN - 0167-7012
ER -