Insufficient sensitivity of laser desorption-time of flight mass spectrometry-based detection of hemozoin for malaria screening

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Insufficient sensitivity of laser desorption-time of flight mass spectrometry-based detection of hemozoin for malaria screening. / Christner, Martin; Frickmann, Hagen; Klupp, Eva; Rohde, Holger; Kono, Maya; Tannich, Egbert; Poppert, Sven.

in: J MICROBIOL METH, Jahrgang 160, 05.2019, S. 104-106.

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@article{dcbf32a08d6d439ba2e5d30d8d2dfd2b,
title = "Insufficient sensitivity of laser desorption-time of flight mass spectrometry-based detection of hemozoin for malaria screening",
abstract = "Laser desorption-time of flight (LD-TOF) mass spectrometry-based detection of hemozoin was assessed for its performance characteristics as a rapid screening test for malaria. In spite of good specificity of >95%, poor sensitivity of 80.2% for microscopically positive samples makes the easy-to-apply and rapid approach unsuitable for the routine diagnostic setting.",
author = "Martin Christner and Hagen Frickmann and Eva Klupp and Holger Rohde and Maya Kono and Egbert Tannich and Sven Poppert",
note = "Copyright {\textcopyright} 2019 Elsevier B.V. All rights reserved.",
year = "2019",
month = may,
doi = "10.1016/j.mimet.2019.04.002",
language = "English",
volume = "160",
pages = "104--106",
journal = "J MICROBIOL METH",
issn = "0167-7012",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Insufficient sensitivity of laser desorption-time of flight mass spectrometry-based detection of hemozoin for malaria screening

AU - Christner, Martin

AU - Frickmann, Hagen

AU - Klupp, Eva

AU - Rohde, Holger

AU - Kono, Maya

AU - Tannich, Egbert

AU - Poppert, Sven

N1 - Copyright © 2019 Elsevier B.V. All rights reserved.

PY - 2019/5

Y1 - 2019/5

N2 - Laser desorption-time of flight (LD-TOF) mass spectrometry-based detection of hemozoin was assessed for its performance characteristics as a rapid screening test for malaria. In spite of good specificity of >95%, poor sensitivity of 80.2% for microscopically positive samples makes the easy-to-apply and rapid approach unsuitable for the routine diagnostic setting.

AB - Laser desorption-time of flight (LD-TOF) mass spectrometry-based detection of hemozoin was assessed for its performance characteristics as a rapid screening test for malaria. In spite of good specificity of >95%, poor sensitivity of 80.2% for microscopically positive samples makes the easy-to-apply and rapid approach unsuitable for the routine diagnostic setting.

U2 - 10.1016/j.mimet.2019.04.002

DO - 10.1016/j.mimet.2019.04.002

M3 - SCORING: Journal article

C2 - 30953660

VL - 160

SP - 104

EP - 106

JO - J MICROBIOL METH

JF - J MICROBIOL METH

SN - 0167-7012

ER -