Induction of IL-22-Producing CD4+ T Cells by Segmented Filamentous Bacteria Independent of Classical Th17 Cells
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Induction of IL-22-Producing CD4+ T Cells by Segmented Filamentous Bacteria Independent of Classical Th17 Cells. / Roy, Urmi; de Oliveira, Rômulo S.; Galvez, Eric J.C.; Gronow, Achim; Basic, Marijana; Perez, Laura Garcia; Gagliani, Nicola; Bleich, Andre; Huber, Samuel; Strowig, Till.
in: FRONT IMMUNOL, Jahrgang 12, 671331, 08.09.2021, S. 671331.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Induction of IL-22-Producing CD4+ T Cells by Segmented Filamentous Bacteria Independent of Classical Th17 Cells
AU - Roy, Urmi
AU - de Oliveira, Rômulo S.
AU - Galvez, Eric J.C.
AU - Gronow, Achim
AU - Basic, Marijana
AU - Perez, Laura Garcia
AU - Gagliani, Nicola
AU - Bleich, Andre
AU - Huber, Samuel
AU - Strowig, Till
N1 - Publisher Copyright: © Copyright © 2021 Roy, de Oliveira, Galvez, Gronow, Basic, Perez, Gagliani, Bleich, Huber and Strowig.
PY - 2021/9/8
Y1 - 2021/9/8
N2 - The intestinal microbiota modulates IL-22 production in the intestine, including the induction of IL-22-producing CD4+ T helper cells. Which specific bacteria are responsible for the induction of these cells is less well understood. Here, we demonstrate through the use of novel gnotobiotic knock-in reporter mice that segmented filamentous bacteria (SFB), which are known for their ability to induce Th17 cells, also induce distinct IL-17A negative CD4+ T cell populations in the intestine. A subset of these cells instead produces IL-22 upon restimulation ex vivo and also during enteric infections. Furthermore, they produce a distinct set of cytokines compared to Th17 cells including the differential expression of IL-17F and IFN-γ. Importantly, genetic models demonstrate that these cells, presumably Th22 cells, develop independently of intestinal Th17 cells. Together, our data identifies that besides Th17, SFB also induces CD4+ T cell populations, which serve as immediate source of IL-22 during intestinal inflammation.
AB - The intestinal microbiota modulates IL-22 production in the intestine, including the induction of IL-22-producing CD4+ T helper cells. Which specific bacteria are responsible for the induction of these cells is less well understood. Here, we demonstrate through the use of novel gnotobiotic knock-in reporter mice that segmented filamentous bacteria (SFB), which are known for their ability to induce Th17 cells, also induce distinct IL-17A negative CD4+ T cell populations in the intestine. A subset of these cells instead produces IL-22 upon restimulation ex vivo and also during enteric infections. Furthermore, they produce a distinct set of cytokines compared to Th17 cells including the differential expression of IL-17F and IFN-γ. Importantly, genetic models demonstrate that these cells, presumably Th22 cells, develop independently of intestinal Th17 cells. Together, our data identifies that besides Th17, SFB also induces CD4+ T cell populations, which serve as immediate source of IL-22 during intestinal inflammation.
KW - bystander activation of T cells
KW - cytokine knock-in reporter mice
KW - IL-22
KW - Salmonella infection
KW - segmented filamentous bacteria (SFB)
KW - Th22 cells
UR - http://www.scopus.com/inward/record.url?scp=85115352309&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2021.671331
DO - 10.3389/fimmu.2021.671331
M3 - SCORING: Journal article
C2 - 34566952
AN - SCOPUS:85115352309
VL - 12
SP - 671331
JO - FRONT IMMUNOL
JF - FRONT IMMUNOL
SN - 1664-3224
M1 - 671331
ER -
