PortalPublikationenIndependent replication of STAT3 association with multiple s...

Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample.

Standard

Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample. / Lill, Christina M; Schjeide, Brit-Maren M; Akkad, Denis A; Blaschke, Paul; Winkelmann, Alexander; Gerdes, Lisa-Ann; Hoffjan, Sabine; Luessi, Felix; Dörner, Thomas; Li, Shu-Chen; Steinhagen-Thiessen, Elisabeth; Lindenberger, Ulman; Chan, Andrew; Hartung, Hans-Peter; Aktas, Orhan; Lohse, Peter; Kümpfel, Tania; Kubisch, Christian; Epplen, Joerg T; Zettl, Uwe K; Bertram, Lars; Zipp, Frauke.

in: NEUROGENETICS, Jahrgang 13, Nr. 1, 1, 2012, S. 83-86.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lill, CM, Schjeide, B-MM, Akkad, DA, Blaschke, P, Winkelmann, A, Gerdes, L-A, Hoffjan, S, Luessi, F, Dörner, T, Li, S-C, Steinhagen-Thiessen, E, Lindenberger, U, Chan, A, Hartung, H-P, Aktas, O, Lohse, P, Kümpfel, T, Kubisch, C, Epplen, JT, Zettl, UK, Bertram, L & Zipp, F 2012, 'Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample.', NEUROGENETICS, Jg. 13, Nr. 1, 1, S. 83-86. <http://www.ncbi.nlm.nih.gov/pubmed/22095036?dopt=Citation>

APA

Lill, C. M., Schjeide, B-M. M., Akkad, D. A., Blaschke, P., Winkelmann, A., Gerdes, L-A., Hoffjan, S., Luessi, F., Dörner, T., Li, S-C., Steinhagen-Thiessen, E., Lindenberger, U., Chan, A., Hartung, H-P., Aktas, O., Lohse, P., Kümpfel, T., Kubisch, C., Epplen, J. T., ... Zipp, F. (2012). Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample. NEUROGENETICS, 13(1), 83-86. [1]. http://www.ncbi.nlm.nih.gov/pubmed/22095036?dopt=Citation

Vancouver

Lill CM, Schjeide B-MM, Akkad DA, Blaschke P, Winkelmann A, Gerdes L-A et al. Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample. NEUROGENETICS. 2012;13(1):83-86. 1.

Bibtex

@article{2088194658ce4566ae6138d242bf8a28,
title = "Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample.",
abstract = "Recent genome-wide association studies have implicated the {"}signal transducer and activator of transcription 3{"} gene (STAT3) as a putative new multiple sclerosis (MS) susceptibility locus. However, independent validation studies are sparse. Therefore, we performed a genetic association study of two STAT3 polymorphisms (rs744166 and rs2293152) in a large and independent German case-control sample of 5,904 subjects. We observed a nominally significant, albeit weak association between rs744166 and MS susceptibility (odds ratio?=?1.09, P?=?0.012) in our sample. This study supports the association between STAT3 and an increase in MS risk. Taking into account the functional role of STAT3, our results favour an involvement of T(h)17 lymphocytes in MS.",
keywords = "Germany, Humans, Female, Genotype, Polymorphism, Single Nucleotide, Case-Control Studies, Risk, *Genetic Predisposition to Disease, Multiple Sclerosis/*genetics, STAT3 Transcription Factor/*genetics, Germany, Humans, Female, Genotype, Polymorphism, Single Nucleotide, Case-Control Studies, Risk, *Genetic Predisposition to Disease, Multiple Sclerosis/*genetics, STAT3 Transcription Factor/*genetics",
author = "Lill, {Christina M} and Schjeide, {Brit-Maren M} and Akkad, {Denis A} and Paul Blaschke and Alexander Winkelmann and Lisa-Ann Gerdes and Sabine Hoffjan and Felix Luessi and Thomas D{\"o}rner and Shu-Chen Li and Elisabeth Steinhagen-Thiessen and Ulman Lindenberger and Andrew Chan and Hans-Peter Hartung and Orhan Aktas and Peter Lohse and Tania K{\"u}mpfel and Christian Kubisch and Epplen, {Joerg T} and Zettl, {Uwe K} and Lars Bertram and Frauke Zipp",
year = "2012",
language = "English",
volume = "13",
pages = "83--86",
journal = "NEUROGENETICS",
issn = "1364-6745",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample.

AU - Lill, Christina M

AU - Schjeide, Brit-Maren M

AU - Akkad, Denis A

AU - Blaschke, Paul

AU - Winkelmann, Alexander

AU - Gerdes, Lisa-Ann

AU - Hoffjan, Sabine

AU - Luessi, Felix

AU - Dörner, Thomas

AU - Li, Shu-Chen

AU - Steinhagen-Thiessen, Elisabeth

AU - Lindenberger, Ulman

AU - Chan, Andrew

AU - Hartung, Hans-Peter

AU - Aktas, Orhan

AU - Lohse, Peter

AU - Kümpfel, Tania

AU - Kubisch, Christian

AU - Epplen, Joerg T

AU - Zettl, Uwe K

AU - Bertram, Lars

AU - Zipp, Frauke

PY - 2012

Y1 - 2012

N2 - Recent genome-wide association studies have implicated the "signal transducer and activator of transcription 3" gene (STAT3) as a putative new multiple sclerosis (MS) susceptibility locus. However, independent validation studies are sparse. Therefore, we performed a genetic association study of two STAT3 polymorphisms (rs744166 and rs2293152) in a large and independent German case-control sample of 5,904 subjects. We observed a nominally significant, albeit weak association between rs744166 and MS susceptibility (odds ratio?=?1.09, P?=?0.012) in our sample. This study supports the association between STAT3 and an increase in MS risk. Taking into account the functional role of STAT3, our results favour an involvement of T(h)17 lymphocytes in MS.

AB - Recent genome-wide association studies have implicated the "signal transducer and activator of transcription 3" gene (STAT3) as a putative new multiple sclerosis (MS) susceptibility locus. However, independent validation studies are sparse. Therefore, we performed a genetic association study of two STAT3 polymorphisms (rs744166 and rs2293152) in a large and independent German case-control sample of 5,904 subjects. We observed a nominally significant, albeit weak association between rs744166 and MS susceptibility (odds ratio?=?1.09, P?=?0.012) in our sample. This study supports the association between STAT3 and an increase in MS risk. Taking into account the functional role of STAT3, our results favour an involvement of T(h)17 lymphocytes in MS.

KW - Germany

KW - Humans

KW - Female

KW - Genotype

KW - Polymorphism, Single Nucleotide

KW - Case-Control Studies

KW - Risk

KW - Genetic Predisposition to Disease

KW - Multiple Sclerosis/genetics

KW - STAT3 Transcription Factor/genetics

KW - Germany

KW - Humans

KW - Female

KW - Genotype

KW - Polymorphism, Single Nucleotide

KW - Case-Control Studies

KW - Risk

KW - Genetic Predisposition to Disease

KW - Multiple Sclerosis/genetics

KW - STAT3 Transcription Factor/genetics

M3 - SCORING: Journal article

VL - 13

SP - 83

EP - 86

JO - NEUROGENETICS

JF - NEUROGENETICS

SN - 1364-6745

IS - 1

M1 - 1

ER -