Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample.
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Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample. / Lill, Christina M; Schjeide, Brit-Maren M; Akkad, Denis A; Blaschke, Paul; Winkelmann, Alexander; Gerdes, Lisa-Ann; Hoffjan, Sabine; Luessi, Felix; Dörner, Thomas; Li, Shu-Chen; Steinhagen-Thiessen, Elisabeth; Lindenberger, Ulman; Chan, Andrew; Hartung, Hans-Peter; Aktas, Orhan; Lohse, Peter; Kümpfel, Tania; Kubisch, Christian; Epplen, Joerg T; Zettl, Uwe K; Bertram, Lars; Zipp, Frauke.
In: NEUROGENETICS, Vol. 13, No. 1, 1, 2012, p. 83-86.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample.
AU - Lill, Christina M
AU - Schjeide, Brit-Maren M
AU - Akkad, Denis A
AU - Blaschke, Paul
AU - Winkelmann, Alexander
AU - Gerdes, Lisa-Ann
AU - Hoffjan, Sabine
AU - Luessi, Felix
AU - Dörner, Thomas
AU - Li, Shu-Chen
AU - Steinhagen-Thiessen, Elisabeth
AU - Lindenberger, Ulman
AU - Chan, Andrew
AU - Hartung, Hans-Peter
AU - Aktas, Orhan
AU - Lohse, Peter
AU - Kümpfel, Tania
AU - Kubisch, Christian
AU - Epplen, Joerg T
AU - Zettl, Uwe K
AU - Bertram, Lars
AU - Zipp, Frauke
PY - 2012
Y1 - 2012
N2 - Recent genome-wide association studies have implicated the "signal transducer and activator of transcription 3" gene (STAT3) as a putative new multiple sclerosis (MS) susceptibility locus. However, independent validation studies are sparse. Therefore, we performed a genetic association study of two STAT3 polymorphisms (rs744166 and rs2293152) in a large and independent German case-control sample of 5,904 subjects. We observed a nominally significant, albeit weak association between rs744166 and MS susceptibility (odds ratio?=?1.09, P?=?0.012) in our sample. This study supports the association between STAT3 and an increase in MS risk. Taking into account the functional role of STAT3, our results favour an involvement of T(h)17 lymphocytes in MS.
AB - Recent genome-wide association studies have implicated the "signal transducer and activator of transcription 3" gene (STAT3) as a putative new multiple sclerosis (MS) susceptibility locus. However, independent validation studies are sparse. Therefore, we performed a genetic association study of two STAT3 polymorphisms (rs744166 and rs2293152) in a large and independent German case-control sample of 5,904 subjects. We observed a nominally significant, albeit weak association between rs744166 and MS susceptibility (odds ratio?=?1.09, P?=?0.012) in our sample. This study supports the association between STAT3 and an increase in MS risk. Taking into account the functional role of STAT3, our results favour an involvement of T(h)17 lymphocytes in MS.
KW - Germany
KW - Humans
KW - Female
KW - Genotype
KW - Polymorphism, Single Nucleotide
KW - Case-Control Studies
KW - Risk
KW - Genetic Predisposition to Disease
KW - Multiple Sclerosis/genetics
KW - STAT3 Transcription Factor/genetics
KW - Germany
KW - Humans
KW - Female
KW - Genotype
KW - Polymorphism, Single Nucleotide
KW - Case-Control Studies
KW - Risk
KW - Genetic Predisposition to Disease
KW - Multiple Sclerosis/genetics
KW - STAT3 Transcription Factor/genetics
M3 - SCORING: Journal article
VL - 13
SP - 83
EP - 86
JO - NEUROGENETICS
JF - NEUROGENETICS
SN - 1364-6745
IS - 1
M1 - 1
ER -