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Human Immunodeficiency Virus 1 and Type I Interferons-Where Sex Makes a Difference

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Human Immunodeficiency Virus 1 and Type I Interferons-Where Sex Makes a Difference. / Ziegler, Susanne Maria; Altfeld, Marcus.

in: FRONT IMMUNOL, Jahrgang 8, 2017, S. 1224.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Ziegler, SM & Altfeld, M 2017, 'Human Immunodeficiency Virus 1 and Type I Interferons-Where Sex Makes a Difference', FRONT IMMUNOL, Jg. 8, S. 1224. https://doi.org/10.3389/fimmu.2017.01224

APA

Ziegler, S. M., & Altfeld, M. (2017). Human Immunodeficiency Virus 1 and Type I Interferons-Where Sex Makes a Difference. FRONT IMMUNOL, 8, 1224. https://doi.org/10.3389/fimmu.2017.01224

Vancouver

Ziegler SM, Altfeld M. Human Immunodeficiency Virus 1 and Type I Interferons-Where Sex Makes a Difference. FRONT IMMUNOL. 2017;8:1224. https://doi.org/10.3389/fimmu.2017.01224

Bibtex

@article{c8b1a37331894843ae8cc98a964ecbaf,
title = "Human Immunodeficiency Virus 1 and Type I Interferons-Where Sex Makes a Difference",
abstract = "The human immunodeficiency virus (HIV)-1 epidemic continues to represent a global health problem that is over-proportionally affecting women from sub-Saharan Africa. Besides social and environmental factors, the modulation of immunological pathways by sex hormones and gene dosage effects of X chromosomal-encoded genes have been suggested to lead to differential outcomes in HIV-1 disease. Women present with lower HIV-1 loads early in infection. However, the progression to AIDS for the same level of viremia is faster in women than in men. Type I interferons (IFNs) play a prominent role in the control of HIV-1 transmission and replication. Continuous stimulation of type I IFNs in chronic viral infections can lead to increased levels of immune activation, which can be higher in HIV-1-infected women than in men. A role of steroid hormone signaling in regulating viral replication has been postulated, which might further account for sex differences observed in HIV-1 infections. Here, we review recent findings and current knowledge on sex-specific differences in HIV-1 infections.",
keywords = "Journal Article, Review",
author = "Ziegler, {Susanne Maria} and Marcus Altfeld",
year = "2017",
doi = "10.3389/fimmu.2017.01224",
language = "English",
volume = "8",
pages = "1224",
journal = "FRONT IMMUNOL",
issn = "1664-3224",
publisher = "Lausanne : Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Human Immunodeficiency Virus 1 and Type I Interferons-Where Sex Makes a Difference

AU - Ziegler, Susanne Maria

AU - Altfeld, Marcus

PY - 2017

Y1 - 2017

N2 - The human immunodeficiency virus (HIV)-1 epidemic continues to represent a global health problem that is over-proportionally affecting women from sub-Saharan Africa. Besides social and environmental factors, the modulation of immunological pathways by sex hormones and gene dosage effects of X chromosomal-encoded genes have been suggested to lead to differential outcomes in HIV-1 disease. Women present with lower HIV-1 loads early in infection. However, the progression to AIDS for the same level of viremia is faster in women than in men. Type I interferons (IFNs) play a prominent role in the control of HIV-1 transmission and replication. Continuous stimulation of type I IFNs in chronic viral infections can lead to increased levels of immune activation, which can be higher in HIV-1-infected women than in men. A role of steroid hormone signaling in regulating viral replication has been postulated, which might further account for sex differences observed in HIV-1 infections. Here, we review recent findings and current knowledge on sex-specific differences in HIV-1 infections.

AB - The human immunodeficiency virus (HIV)-1 epidemic continues to represent a global health problem that is over-proportionally affecting women from sub-Saharan Africa. Besides social and environmental factors, the modulation of immunological pathways by sex hormones and gene dosage effects of X chromosomal-encoded genes have been suggested to lead to differential outcomes in HIV-1 disease. Women present with lower HIV-1 loads early in infection. However, the progression to AIDS for the same level of viremia is faster in women than in men. Type I interferons (IFNs) play a prominent role in the control of HIV-1 transmission and replication. Continuous stimulation of type I IFNs in chronic viral infections can lead to increased levels of immune activation, which can be higher in HIV-1-infected women than in men. A role of steroid hormone signaling in regulating viral replication has been postulated, which might further account for sex differences observed in HIV-1 infections. Here, we review recent findings and current knowledge on sex-specific differences in HIV-1 infections.

KW - Journal Article

KW - Review

U2 - 10.3389/fimmu.2017.01224

DO - 10.3389/fimmu.2017.01224

M3 - SCORING: Review article

C2 - 29033943

VL - 8

SP - 1224

JO - FRONT IMMUNOL

JF - FRONT IMMUNOL

SN - 1664-3224

ER -