Human erythrocyte fragmentation during ex-vivo pig organ perfusion
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Human erythrocyte fragmentation during ex-vivo pig organ perfusion. / Habibabady, Zahra; Sendil, Selin; Ellett, Felix; Pollok, Franziska; Elias, Gabriela ; French, Beth; Sun, Wenji; Braileanu, Gheorghe; Burdorf, Lars; Irimia, Daniel; Pierson, Richard N; Azimzadeh, Agnes.
in: XENOTRANSPLANTATION, Jahrgang 29, Nr. 2, e12729, 29.03.2022, S. e12729.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Human erythrocyte fragmentation during ex-vivo pig organ perfusion
AU - Habibabady, Zahra
AU - Sendil, Selin
AU - Ellett, Felix
AU - Pollok, Franziska
AU - Elias, Gabriela
AU - French, Beth
AU - Sun, Wenji
AU - Braileanu, Gheorghe
AU - Burdorf, Lars
AU - Irimia, Daniel
AU - Pierson, Richard N
AU - Azimzadeh, Agnes
PY - 2022/3/29
Y1 - 2022/3/29
N2 - Platelet sequestration is a common process during organ reperfusion after transplantation. However, instead of lower platelet counts, when using traditional hemocytometers and light microscopy, we observed physiologically implausible platelet counts in the course of ex-vivo lung and liver xenograft organ perfusion studies. We employed conventional flow cytometry (FC) and imaging FC (AMINS ImageStream X) to investigate the findings and found platelet-sized fragments in the circulation that are mainly derived from red blood cell membranes. We speculate that this erythrocyte fragmentation contributes to anemia during in-vivo organ xenotransplant.
AB - Platelet sequestration is a common process during organ reperfusion after transplantation. However, instead of lower platelet counts, when using traditional hemocytometers and light microscopy, we observed physiologically implausible platelet counts in the course of ex-vivo lung and liver xenograft organ perfusion studies. We employed conventional flow cytometry (FC) and imaging FC (AMINS ImageStream X) to investigate the findings and found platelet-sized fragments in the circulation that are mainly derived from red blood cell membranes. We speculate that this erythrocyte fragmentation contributes to anemia during in-vivo organ xenotransplant.
U2 - 10.1111/xen.12729
DO - 10.1111/xen.12729
M3 - SCORING: Journal article
C2 - 35112383
VL - 29
SP - e12729
JO - XENOTRANSPLANTATION
JF - XENOTRANSPLANTATION
SN - 0908-665X
IS - 2
M1 - e12729
ER -