Elevated MUC5AC expression is associated with mismatch repair deficiency and proximal tumor location but not with cancer progression in colon cancer
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Elevated MUC5AC expression is associated with mismatch repair deficiency and proximal tumor location but not with cancer progression in colon cancer. / Rico, Sebastian Dwertmann; Höflmayer, Doris; Büscheck, Franziska; Dum, David; Luebke, Andreas M; Kluth, Martina; Hube-Magg, Claudia; Hinsch, Andrea; Möller-Koop, Christina; Perez, Daniel; Izbicki, Jakob R; Neipp, Michael; Mofid, Hamid; Lárusson, Hannes; Daniels, Thies; Isbert, Christoph; Coerper, Stephan; Ditterich, Daniel; Rupprecht, Holger; Goetz, Albert; Fraune, Christoph; Möller, Katharina; Menz, Anne; Bernreuther, Christian; Clauditz, Till S; Sauter, Guido; Uhlig, Ria; Wilczak, Waldemar; Simon, Ronald; Steurer, Stefan; Lebok, Patrick; Burandt, Eike; Krech, Till; Marx, Andreas H.
in: MED MOL MORPHOL, Jahrgang 54, Nr. 2, 06.2021, S. 156-165.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Elevated MUC5AC expression is associated with mismatch repair deficiency and proximal tumor location but not with cancer progression in colon cancer
AU - Rico, Sebastian Dwertmann
AU - Höflmayer, Doris
AU - Büscheck, Franziska
AU - Dum, David
AU - Luebke, Andreas M
AU - Kluth, Martina
AU - Hube-Magg, Claudia
AU - Hinsch, Andrea
AU - Möller-Koop, Christina
AU - Perez, Daniel
AU - Izbicki, Jakob R
AU - Neipp, Michael
AU - Mofid, Hamid
AU - Lárusson, Hannes
AU - Daniels, Thies
AU - Isbert, Christoph
AU - Coerper, Stephan
AU - Ditterich, Daniel
AU - Rupprecht, Holger
AU - Goetz, Albert
AU - Fraune, Christoph
AU - Möller, Katharina
AU - Menz, Anne
AU - Bernreuther, Christian
AU - Clauditz, Till S
AU - Sauter, Guido
AU - Uhlig, Ria
AU - Wilczak, Waldemar
AU - Simon, Ronald
AU - Steurer, Stefan
AU - Lebok, Patrick
AU - Burandt, Eike
AU - Krech, Till
AU - Marx, Andreas H
PY - 2021/6
Y1 - 2021/6
N2 - Mucin 5AC (MUC5AC) is a secreted gel-forming mucin expressed by several epithelia. In the colon, MUC5AC is expressed in scattered normal epithelial cells but can be abundant in colorectal cancers. To clarify the relationship of MUC5AC expression with parameters of tumor aggressiveness and mismatch repair deficiency (dMMR) in colorectal cancer, a tissue microarray containing 1812 colorectal cancers was analyzed by immunohistochemistry. MUC5AC expression was found in 261 (15.7%) of 1,667 analyzable colorectal cancers. MUC5AC expression strongly depended on the tumor location and gradually decreased from proximal (27.4% of cecum cancers) to distal (10.6% of rectal cancers; p < 0.0001). MUC5AC expression was also strongly linked to dMMR. dMMR was found in 21.3% of 169 cancers with MUC5AC positivity but in only 4.6% of 1051 cancers without detectable MUC5AC expression (p < 0.0001). A multivariate analysis showed that dMMR status and tumor localization predicted MUC5AC expression independently (p < 0.0001 each). MUC5AC expression was unrelated to pT and pN status. This also applied to the subgroups of 1136 proficient MMR (pMMR) and of 84 dMMR cancers. The results of our study show a strong association of MUC5AC expression with proximal and dMMR colorectal cancers. However, MUC5AC expression is unrelated to colon cancer aggressiveness.
AB - Mucin 5AC (MUC5AC) is a secreted gel-forming mucin expressed by several epithelia. In the colon, MUC5AC is expressed in scattered normal epithelial cells but can be abundant in colorectal cancers. To clarify the relationship of MUC5AC expression with parameters of tumor aggressiveness and mismatch repair deficiency (dMMR) in colorectal cancer, a tissue microarray containing 1812 colorectal cancers was analyzed by immunohistochemistry. MUC5AC expression was found in 261 (15.7%) of 1,667 analyzable colorectal cancers. MUC5AC expression strongly depended on the tumor location and gradually decreased from proximal (27.4% of cecum cancers) to distal (10.6% of rectal cancers; p < 0.0001). MUC5AC expression was also strongly linked to dMMR. dMMR was found in 21.3% of 169 cancers with MUC5AC positivity but in only 4.6% of 1051 cancers without detectable MUC5AC expression (p < 0.0001). A multivariate analysis showed that dMMR status and tumor localization predicted MUC5AC expression independently (p < 0.0001 each). MUC5AC expression was unrelated to pT and pN status. This also applied to the subgroups of 1136 proficient MMR (pMMR) and of 84 dMMR cancers. The results of our study show a strong association of MUC5AC expression with proximal and dMMR colorectal cancers. However, MUC5AC expression is unrelated to colon cancer aggressiveness.
U2 - 10.1007/s00795-020-00274-2
DO - 10.1007/s00795-020-00274-2
M3 - SCORING: Journal article
C2 - 33373033
VL - 54
SP - 156
EP - 165
JO - MED MOL MORPHOL
JF - MED MOL MORPHOL
SN - 1860-1480
IS - 2
ER -