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Elevated MUC5AC expression is associated with mismatch repair deficiency and proximal tumor location but not with cancer progression in colon cancer

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Elevated MUC5AC expression is associated with mismatch repair deficiency and proximal tumor location but not with cancer progression in colon cancer. / Rico, Sebastian Dwertmann; Höflmayer, Doris; Büscheck, Franziska; Dum, David; Luebke, Andreas M; Kluth, Martina; Hube-Magg, Claudia; Hinsch, Andrea; Möller-Koop, Christina; Perez, Daniel; Izbicki, Jakob R; Neipp, Michael; Mofid, Hamid; Lárusson, Hannes; Daniels, Thies; Isbert, Christoph; Coerper, Stephan; Ditterich, Daniel; Rupprecht, Holger; Goetz, Albert; Fraune, Christoph; Möller, Katharina; Menz, Anne; Bernreuther, Christian; Clauditz, Till S; Sauter, Guido; Uhlig, Ria; Wilczak, Waldemar; Simon, Ronald; Steurer, Stefan; Lebok, Patrick; Burandt, Eike; Krech, Till; Marx, Andreas H.

In: MED MOL MORPHOL, Vol. 54, No. 2, 06.2021, p. 156-165.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rico, SD, Höflmayer, D, Büscheck, F, Dum, D, Luebke, AM, Kluth, M, Hube-Magg, C, Hinsch, A, Möller-Koop, C, Perez, D, Izbicki, JR, Neipp, M, Mofid, H, Lárusson, H, Daniels, T, Isbert, C, Coerper, S, Ditterich, D, Rupprecht, H, Goetz, A, Fraune, C, Möller, K, Menz, A, Bernreuther, C, Clauditz, TS, Sauter, G, Uhlig, R, Wilczak, W, Simon, R, Steurer, S, Lebok, P, Burandt, E, Krech, T & Marx, AH 2021, 'Elevated MUC5AC expression is associated with mismatch repair deficiency and proximal tumor location but not with cancer progression in colon cancer', MED MOL MORPHOL, vol. 54, no. 2, pp. 156-165. https://doi.org/10.1007/s00795-020-00274-2

APA

Rico, S. D., Höflmayer, D., Büscheck, F., Dum, D., Luebke, A. M., Kluth, M., Hube-Magg, C., Hinsch, A., Möller-Koop, C., Perez, D., Izbicki, J. R., Neipp, M., Mofid, H., Lárusson, H., Daniels, T., Isbert, C., Coerper, S., Ditterich, D., Rupprecht, H., ... Marx, A. H. (2021). Elevated MUC5AC expression is associated with mismatch repair deficiency and proximal tumor location but not with cancer progression in colon cancer. MED MOL MORPHOL, 54(2), 156-165. https://doi.org/10.1007/s00795-020-00274-2

Vancouver

Rico SD, Höflmayer D, Büscheck F, Dum D, Luebke AM, Kluth M et al. Elevated MUC5AC expression is associated with mismatch repair deficiency and proximal tumor location but not with cancer progression in colon cancer. MED MOL MORPHOL. 2021 Jun;54(2):156-165. https://doi.org/10.1007/s00795-020-00274-2

Bibtex

@article{1737793efbc2420db4f24d3406adccc7,
title = "Elevated MUC5AC expression is associated with mismatch repair deficiency and proximal tumor location but not with cancer progression in colon cancer",
abstract = "Mucin 5AC (MUC5AC) is a secreted gel-forming mucin expressed by several epithelia. In the colon, MUC5AC is expressed in scattered normal epithelial cells but can be abundant in colorectal cancers. To clarify the relationship of MUC5AC expression with parameters of tumor aggressiveness and mismatch repair deficiency (dMMR) in colorectal cancer, a tissue microarray containing 1812 colorectal cancers was analyzed by immunohistochemistry. MUC5AC expression was found in 261 (15.7%) of 1,667 analyzable colorectal cancers. MUC5AC expression strongly depended on the tumor location and gradually decreased from proximal (27.4% of cecum cancers) to distal (10.6% of rectal cancers; p < 0.0001). MUC5AC expression was also strongly linked to dMMR. dMMR was found in 21.3% of 169 cancers with MUC5AC positivity but in only 4.6% of 1051 cancers without detectable MUC5AC expression (p < 0.0001). A multivariate analysis showed that dMMR status and tumor localization predicted MUC5AC expression independently (p < 0.0001 each). MUC5AC expression was unrelated to pT and pN status. This also applied to the subgroups of 1136 proficient MMR (pMMR) and of 84 dMMR cancers. The results of our study show a strong association of MUC5AC expression with proximal and dMMR colorectal cancers. However, MUC5AC expression is unrelated to colon cancer aggressiveness.",
author = "Rico, {Sebastian Dwertmann} and Doris H{\"o}flmayer and Franziska B{\"u}scheck and David Dum and Luebke, {Andreas M} and Martina Kluth and Claudia Hube-Magg and Andrea Hinsch and Christina M{\"o}ller-Koop and Daniel Perez and Izbicki, {Jakob R} and Michael Neipp and Hamid Mofid and Hannes L{\'a}russon and Thies Daniels and Christoph Isbert and Stephan Coerper and Daniel Ditterich and Holger Rupprecht and Albert Goetz and Christoph Fraune and Katharina M{\"o}ller and Anne Menz and Christian Bernreuther and Clauditz, {Till S} and Guido Sauter and Ria Uhlig and Waldemar Wilczak and Ronald Simon and Stefan Steurer and Patrick Lebok and Eike Burandt and Till Krech and Marx, {Andreas H}",
year = "2021",
month = jun,
doi = "10.1007/s00795-020-00274-2",
language = "English",
volume = "54",
pages = "156--165",
journal = "MED MOL MORPHOL",
issn = "1860-1480",
publisher = "Springer Japan",
number = "2",

}

RIS

TY - JOUR

T1 - Elevated MUC5AC expression is associated with mismatch repair deficiency and proximal tumor location but not with cancer progression in colon cancer

AU - Rico, Sebastian Dwertmann

AU - Höflmayer, Doris

AU - Büscheck, Franziska

AU - Dum, David

AU - Luebke, Andreas M

AU - Kluth, Martina

AU - Hube-Magg, Claudia

AU - Hinsch, Andrea

AU - Möller-Koop, Christina

AU - Perez, Daniel

AU - Izbicki, Jakob R

AU - Neipp, Michael

AU - Mofid, Hamid

AU - Lárusson, Hannes

AU - Daniels, Thies

AU - Isbert, Christoph

AU - Coerper, Stephan

AU - Ditterich, Daniel

AU - Rupprecht, Holger

AU - Goetz, Albert

AU - Fraune, Christoph

AU - Möller, Katharina

AU - Menz, Anne

AU - Bernreuther, Christian

AU - Clauditz, Till S

AU - Sauter, Guido

AU - Uhlig, Ria

AU - Wilczak, Waldemar

AU - Simon, Ronald

AU - Steurer, Stefan

AU - Lebok, Patrick

AU - Burandt, Eike

AU - Krech, Till

AU - Marx, Andreas H

PY - 2021/6

Y1 - 2021/6

N2 - Mucin 5AC (MUC5AC) is a secreted gel-forming mucin expressed by several epithelia. In the colon, MUC5AC is expressed in scattered normal epithelial cells but can be abundant in colorectal cancers. To clarify the relationship of MUC5AC expression with parameters of tumor aggressiveness and mismatch repair deficiency (dMMR) in colorectal cancer, a tissue microarray containing 1812 colorectal cancers was analyzed by immunohistochemistry. MUC5AC expression was found in 261 (15.7%) of 1,667 analyzable colorectal cancers. MUC5AC expression strongly depended on the tumor location and gradually decreased from proximal (27.4% of cecum cancers) to distal (10.6% of rectal cancers; p < 0.0001). MUC5AC expression was also strongly linked to dMMR. dMMR was found in 21.3% of 169 cancers with MUC5AC positivity but in only 4.6% of 1051 cancers without detectable MUC5AC expression (p < 0.0001). A multivariate analysis showed that dMMR status and tumor localization predicted MUC5AC expression independently (p < 0.0001 each). MUC5AC expression was unrelated to pT and pN status. This also applied to the subgroups of 1136 proficient MMR (pMMR) and of 84 dMMR cancers. The results of our study show a strong association of MUC5AC expression with proximal and dMMR colorectal cancers. However, MUC5AC expression is unrelated to colon cancer aggressiveness.

AB - Mucin 5AC (MUC5AC) is a secreted gel-forming mucin expressed by several epithelia. In the colon, MUC5AC is expressed in scattered normal epithelial cells but can be abundant in colorectal cancers. To clarify the relationship of MUC5AC expression with parameters of tumor aggressiveness and mismatch repair deficiency (dMMR) in colorectal cancer, a tissue microarray containing 1812 colorectal cancers was analyzed by immunohistochemistry. MUC5AC expression was found in 261 (15.7%) of 1,667 analyzable colorectal cancers. MUC5AC expression strongly depended on the tumor location and gradually decreased from proximal (27.4% of cecum cancers) to distal (10.6% of rectal cancers; p < 0.0001). MUC5AC expression was also strongly linked to dMMR. dMMR was found in 21.3% of 169 cancers with MUC5AC positivity but in only 4.6% of 1051 cancers without detectable MUC5AC expression (p < 0.0001). A multivariate analysis showed that dMMR status and tumor localization predicted MUC5AC expression independently (p < 0.0001 each). MUC5AC expression was unrelated to pT and pN status. This also applied to the subgroups of 1136 proficient MMR (pMMR) and of 84 dMMR cancers. The results of our study show a strong association of MUC5AC expression with proximal and dMMR colorectal cancers. However, MUC5AC expression is unrelated to colon cancer aggressiveness.

U2 - 10.1007/s00795-020-00274-2

DO - 10.1007/s00795-020-00274-2

M3 - SCORING: Journal article

C2 - 33373033

VL - 54

SP - 156

EP - 165

JO - MED MOL MORPHOL

JF - MED MOL MORPHOL

SN - 1860-1480

IS - 2

ER -