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Effects of acute cortisol administration on response inhibition in patients with major depression and healthy controls

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Effects of acute cortisol administration on response inhibition in patients with major depression and healthy controls. / Schlosser, Nicole; Wolf, Oliver Tobias; Fernando, Silvia Carvalho; Terfehr, Kirsten; Otte, Christian; Spitzer, Carsten; Beblo, Thomas; Driessen, Martin; Löwe, Bernd; Wingenfeld, Katja.

in: PSYCHIAT RES, Jahrgang 209, Nr. 3, 30.10.2013, S. 439-46.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schlosser, N, Wolf, OT, Fernando, SC, Terfehr, K, Otte, C, Spitzer, C, Beblo, T, Driessen, M, Löwe, B & Wingenfeld, K 2013, 'Effects of acute cortisol administration on response inhibition in patients with major depression and healthy controls', PSYCHIAT RES, Jg. 209, Nr. 3, S. 439-46. https://doi.org/10.1016/j.psychres.2012.12.019

APA

Schlosser, N., Wolf, O. T., Fernando, S. C., Terfehr, K., Otte, C., Spitzer, C., Beblo, T., Driessen, M., Löwe, B., & Wingenfeld, K. (2013). Effects of acute cortisol administration on response inhibition in patients with major depression and healthy controls. PSYCHIAT RES, 209(3), 439-46. https://doi.org/10.1016/j.psychres.2012.12.019

Vancouver

Schlosser N, Wolf OT, Fernando SC, Terfehr K, Otte C, Spitzer C et al. Effects of acute cortisol administration on response inhibition in patients with major depression and healthy controls. PSYCHIAT RES. 2013 Okt 30;209(3):439-46. https://doi.org/10.1016/j.psychres.2012.12.019

Bibtex

@article{75e244e24512459a8c2ae4ddd7af95d4,
title = "Effects of acute cortisol administration on response inhibition in patients with major depression and healthy controls",
abstract = "Glucocorticoids (GCs) have repeatedly been shown to impair hippocampus-mediated, declarative memory retrieval and prefrontal cortex-based working memory in healthy subjects. However, recent experimental studies indicated that patients with major depressive disorder (MDD) lack these impairing effects. These missing effects have been suggested to result from dysfunctional brain GC receptors. The purpose of the present study was to investigate whether response inhibition, an executive function relying on the integrity of the prefrontal cortex, would be impaired after cortisol administration in patients with MDD. In a placebo-controlled, double blind crossover study, 50 inpatients with MDD and 54 healthy control participants conducted an emotional go/no-go task consisting of human face stimuli (fearful, happy, and neutral) after receiving a dose of 10 mg hydrocortisone and after placebo. GC administration had an enhancing effect on inhibitory performance in healthy control participants, indicated by faster responses, while no GC effect was revealed for the patients group. Moreover, patients showed an overall worse performance than healthy participants. In conclusion, this study further supports the hypothesis of impaired central glucocorticoid receptor function in MDD patients. Regarding the importance of inhibitory functioning for daily living, further studies are needed to examine the impact of glucocorticoids on response inhibition.",
keywords = "Adult, Cognition Disorders, Decision Making, Depressive Disorder, Major, Double-Blind Method, Executive Function, Female, Humans, Hydrocortisone, Inhibition (Psychology), Inpatients, Male, Middle Aged, Neuropsychological Tests, Photic Stimulation, Reaction Time, Saliva, Time Factors, Young Adult",
author = "Nicole Schlosser and Wolf, {Oliver Tobias} and Fernando, {Silvia Carvalho} and Kirsten Terfehr and Christian Otte and Carsten Spitzer and Thomas Beblo and Martin Driessen and Bernd L{\"o}we and Katja Wingenfeld",
note = "Copyright {\textcopyright} 2012 Elsevier Ireland Ltd. All rights reserved.",
year = "2013",
month = oct,
day = "30",
doi = "10.1016/j.psychres.2012.12.019",
language = "English",
volume = "209",
pages = "439--46",
journal = "PSYCHIAT RES",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Effects of acute cortisol administration on response inhibition in patients with major depression and healthy controls

AU - Schlosser, Nicole

AU - Wolf, Oliver Tobias

AU - Fernando, Silvia Carvalho

AU - Terfehr, Kirsten

AU - Otte, Christian

AU - Spitzer, Carsten

AU - Beblo, Thomas

AU - Driessen, Martin

AU - Löwe, Bernd

AU - Wingenfeld, Katja

N1 - Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

PY - 2013/10/30

Y1 - 2013/10/30

N2 - Glucocorticoids (GCs) have repeatedly been shown to impair hippocampus-mediated, declarative memory retrieval and prefrontal cortex-based working memory in healthy subjects. However, recent experimental studies indicated that patients with major depressive disorder (MDD) lack these impairing effects. These missing effects have been suggested to result from dysfunctional brain GC receptors. The purpose of the present study was to investigate whether response inhibition, an executive function relying on the integrity of the prefrontal cortex, would be impaired after cortisol administration in patients with MDD. In a placebo-controlled, double blind crossover study, 50 inpatients with MDD and 54 healthy control participants conducted an emotional go/no-go task consisting of human face stimuli (fearful, happy, and neutral) after receiving a dose of 10 mg hydrocortisone and after placebo. GC administration had an enhancing effect on inhibitory performance in healthy control participants, indicated by faster responses, while no GC effect was revealed for the patients group. Moreover, patients showed an overall worse performance than healthy participants. In conclusion, this study further supports the hypothesis of impaired central glucocorticoid receptor function in MDD patients. Regarding the importance of inhibitory functioning for daily living, further studies are needed to examine the impact of glucocorticoids on response inhibition.

AB - Glucocorticoids (GCs) have repeatedly been shown to impair hippocampus-mediated, declarative memory retrieval and prefrontal cortex-based working memory in healthy subjects. However, recent experimental studies indicated that patients with major depressive disorder (MDD) lack these impairing effects. These missing effects have been suggested to result from dysfunctional brain GC receptors. The purpose of the present study was to investigate whether response inhibition, an executive function relying on the integrity of the prefrontal cortex, would be impaired after cortisol administration in patients with MDD. In a placebo-controlled, double blind crossover study, 50 inpatients with MDD and 54 healthy control participants conducted an emotional go/no-go task consisting of human face stimuli (fearful, happy, and neutral) after receiving a dose of 10 mg hydrocortisone and after placebo. GC administration had an enhancing effect on inhibitory performance in healthy control participants, indicated by faster responses, while no GC effect was revealed for the patients group. Moreover, patients showed an overall worse performance than healthy participants. In conclusion, this study further supports the hypothesis of impaired central glucocorticoid receptor function in MDD patients. Regarding the importance of inhibitory functioning for daily living, further studies are needed to examine the impact of glucocorticoids on response inhibition.

KW - Adult

KW - Cognition Disorders

KW - Decision Making

KW - Depressive Disorder, Major

KW - Double-Blind Method

KW - Executive Function

KW - Female

KW - Humans

KW - Hydrocortisone

KW - Inhibition (Psychology)

KW - Inpatients

KW - Male

KW - Middle Aged

KW - Neuropsychological Tests

KW - Photic Stimulation

KW - Reaction Time

KW - Saliva

KW - Time Factors

KW - Young Adult

U2 - 10.1016/j.psychres.2012.12.019

DO - 10.1016/j.psychres.2012.12.019

M3 - SCORING: Journal article

C2 - 23332680

VL - 209

SP - 439

EP - 446

JO - PSYCHIAT RES

JF - PSYCHIAT RES

SN - 0165-1781

IS - 3

ER -