Effects of acute cortisol administration on response inhibition in patients with major depression and healthy controls
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Effects of acute cortisol administration on response inhibition in patients with major depression and healthy controls. / Schlosser, Nicole; Wolf, Oliver Tobias; Fernando, Silvia Carvalho; Terfehr, Kirsten; Otte, Christian; Spitzer, Carsten; Beblo, Thomas; Driessen, Martin; Löwe, Bernd; Wingenfeld, Katja.
In: PSYCHIAT RES, Vol. 209, No. 3, 30.10.2013, p. 439-46.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Effects of acute cortisol administration on response inhibition in patients with major depression and healthy controls
AU - Schlosser, Nicole
AU - Wolf, Oliver Tobias
AU - Fernando, Silvia Carvalho
AU - Terfehr, Kirsten
AU - Otte, Christian
AU - Spitzer, Carsten
AU - Beblo, Thomas
AU - Driessen, Martin
AU - Löwe, Bernd
AU - Wingenfeld, Katja
N1 - Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
PY - 2013/10/30
Y1 - 2013/10/30
N2 - Glucocorticoids (GCs) have repeatedly been shown to impair hippocampus-mediated, declarative memory retrieval and prefrontal cortex-based working memory in healthy subjects. However, recent experimental studies indicated that patients with major depressive disorder (MDD) lack these impairing effects. These missing effects have been suggested to result from dysfunctional brain GC receptors. The purpose of the present study was to investigate whether response inhibition, an executive function relying on the integrity of the prefrontal cortex, would be impaired after cortisol administration in patients with MDD. In a placebo-controlled, double blind crossover study, 50 inpatients with MDD and 54 healthy control participants conducted an emotional go/no-go task consisting of human face stimuli (fearful, happy, and neutral) after receiving a dose of 10 mg hydrocortisone and after placebo. GC administration had an enhancing effect on inhibitory performance in healthy control participants, indicated by faster responses, while no GC effect was revealed for the patients group. Moreover, patients showed an overall worse performance than healthy participants. In conclusion, this study further supports the hypothesis of impaired central glucocorticoid receptor function in MDD patients. Regarding the importance of inhibitory functioning for daily living, further studies are needed to examine the impact of glucocorticoids on response inhibition.
AB - Glucocorticoids (GCs) have repeatedly been shown to impair hippocampus-mediated, declarative memory retrieval and prefrontal cortex-based working memory in healthy subjects. However, recent experimental studies indicated that patients with major depressive disorder (MDD) lack these impairing effects. These missing effects have been suggested to result from dysfunctional brain GC receptors. The purpose of the present study was to investigate whether response inhibition, an executive function relying on the integrity of the prefrontal cortex, would be impaired after cortisol administration in patients with MDD. In a placebo-controlled, double blind crossover study, 50 inpatients with MDD and 54 healthy control participants conducted an emotional go/no-go task consisting of human face stimuli (fearful, happy, and neutral) after receiving a dose of 10 mg hydrocortisone and after placebo. GC administration had an enhancing effect on inhibitory performance in healthy control participants, indicated by faster responses, while no GC effect was revealed for the patients group. Moreover, patients showed an overall worse performance than healthy participants. In conclusion, this study further supports the hypothesis of impaired central glucocorticoid receptor function in MDD patients. Regarding the importance of inhibitory functioning for daily living, further studies are needed to examine the impact of glucocorticoids on response inhibition.
KW - Adult
KW - Cognition Disorders
KW - Decision Making
KW - Depressive Disorder, Major
KW - Double-Blind Method
KW - Executive Function
KW - Female
KW - Humans
KW - Hydrocortisone
KW - Inhibition (Psychology)
KW - Inpatients
KW - Male
KW - Middle Aged
KW - Neuropsychological Tests
KW - Photic Stimulation
KW - Reaction Time
KW - Saliva
KW - Time Factors
KW - Young Adult
U2 - 10.1016/j.psychres.2012.12.019
DO - 10.1016/j.psychres.2012.12.019
M3 - SCORING: Journal article
C2 - 23332680
VL - 209
SP - 439
EP - 446
JO - PSYCHIAT RES
JF - PSYCHIAT RES
SN - 0165-1781
IS - 3
ER -