Effect of kidney disease on glucose handling (including genetic defects)
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Effect of kidney disease on glucose handling (including genetic defects). / Calado, Joaquim; Santer, René; Rueff, José.
in: Kidney international. Supplement, Nr. 120, 03.2011, S. S7-13.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Effect of kidney disease on glucose handling (including genetic defects)
AU - Calado, Joaquim
AU - Santer, René
AU - Rueff, José
PY - 2011/3
Y1 - 2011/3
N2 - Reabsorption of glucose in the proximal renal tubule involves the Na(+)-coupled glucose cotransporter (SGLT) and the facilitative glucose transport (GLUT) multigene glucose transport families. Mutations in SLC5A2, the SGLT2 coding gene, are responsible for familial renal glucosuria (FRG), a genetic disorder characterized by glucosuria in the absence of both hyperglycemia and generalized proximal tubular dysfunction. In this paper we focus on FRG and describe other inherited and acquired clinical conditions associated with glucosuria. In addition, a brief review on the regulation of renal glucose transport in diabetes is provided.
AB - Reabsorption of glucose in the proximal renal tubule involves the Na(+)-coupled glucose cotransporter (SGLT) and the facilitative glucose transport (GLUT) multigene glucose transport families. Mutations in SLC5A2, the SGLT2 coding gene, are responsible for familial renal glucosuria (FRG), a genetic disorder characterized by glucosuria in the absence of both hyperglycemia and generalized proximal tubular dysfunction. In this paper we focus on FRG and describe other inherited and acquired clinical conditions associated with glucosuria. In addition, a brief review on the regulation of renal glucose transport in diabetes is provided.
KW - Animals
KW - Genetic Association Studies
KW - Glycosuria/genetics
KW - Humans
KW - Kidney Diseases/genetics
KW - Malabsorption Syndromes
KW - Mice
KW - Monosaccharide Transport Proteins/genetics
U2 - 10.1038/ki.2010.510
DO - 10.1038/ki.2010.510
M3 - SCORING: Review article
C2 - 21358700
SP - S7-13
IS - 120
ER -