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Ebola virus infection kinetics in chimeric mice reveal a key role of T cells as barriers for virus dissemination

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Ebola virus infection kinetics in chimeric mice reveal a key role of T cells as barriers for virus dissemination. / Lüdtke, Anja; Ruibal, Paula; Wozniak, David M; Pallasch, Elisa; Wurr, Stephanie; Bockholt, Sabrina; Gómez-Medina, Sergio; Qiu, Xiangguo; Kobinger, Gary P; Rodríguez, Estefanía; Günther, Stephan; Krasemann, Susanne; Idoyaga, Juliana; Oestereich, Lisa; Muñoz-Fontela, César.

in: SCI REP-UK, Jahrgang 7, 03.03.2017, S. 43776.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lüdtke, A, Ruibal, P, Wozniak, DM, Pallasch, E, Wurr, S, Bockholt, S, Gómez-Medina, S, Qiu, X, Kobinger, GP, Rodríguez, E, Günther, S, Krasemann, S, Idoyaga, J, Oestereich, L & Muñoz-Fontela, C 2017, 'Ebola virus infection kinetics in chimeric mice reveal a key role of T cells as barriers for virus dissemination', SCI REP-UK, Jg. 7, S. 43776. https://doi.org/10.1038/srep43776

APA

Lüdtke, A., Ruibal, P., Wozniak, D. M., Pallasch, E., Wurr, S., Bockholt, S., Gómez-Medina, S., Qiu, X., Kobinger, G. P., Rodríguez, E., Günther, S., Krasemann, S., Idoyaga, J., Oestereich, L., & Muñoz-Fontela, C. (2017). Ebola virus infection kinetics in chimeric mice reveal a key role of T cells as barriers for virus dissemination. SCI REP-UK, 7, 43776. https://doi.org/10.1038/srep43776

Vancouver

Lüdtke A, Ruibal P, Wozniak DM, Pallasch E, Wurr S, Bockholt S et al. Ebola virus infection kinetics in chimeric mice reveal a key role of T cells as barriers for virus dissemination. SCI REP-UK. 2017 Mär 3;7:43776. https://doi.org/10.1038/srep43776

Bibtex

@article{6b5037042c8147dcbf0fbbc45982311b,
title = "Ebola virus infection kinetics in chimeric mice reveal a key role of T cells as barriers for virus dissemination",
abstract = "Ebola virus (EBOV) causes severe systemic disease in humans and non-human primates characterized by high levels of viremia and virus titers in peripheral organs. The natural portals of virus entry are the mucosal surfaces and the skin where macrophages and dendritic cells (DCs) are primary EBOV targets. Due to the migratory properties of DCs, EBOV infection of these cells has been proposed as a necessary step for virus dissemination via draining lymph nodes and blood. Here we utilize chimeric mice with competent hematopoietic-driven immunity, to show that EBOV primarily infects CD11b(+) DCs in non-lymphoid and lymphoid tissues, but spares the main cross-presenting CD103(+) DC subset. Furthermore, depletion of CD8 and CD4 T cells resulted in loss of early control of virus replication, viremia and fatal Ebola virus disease (EVD). Thus, our findings point out at T cell function as a key determinant of EVD progress and outcome.",
keywords = "Journal Article",
author = "Anja L{\"u}dtke and Paula Ruibal and Wozniak, {David M} and Elisa Pallasch and Stephanie Wurr and Sabrina Bockholt and Sergio G{\'o}mez-Medina and Xiangguo Qiu and Kobinger, {Gary P} and Estefan{\'i}a Rodr{\'i}guez and Stephan G{\"u}nther and Susanne Krasemann and Juliana Idoyaga and Lisa Oestereich and C{\'e}sar Mu{\~n}oz-Fontela",
year = "2017",
month = mar,
day = "3",
doi = "10.1038/srep43776",
language = "English",
volume = "7",
pages = "43776",
journal = "SCI REP-UK",
issn = "2045-2322",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Ebola virus infection kinetics in chimeric mice reveal a key role of T cells as barriers for virus dissemination

AU - Lüdtke, Anja

AU - Ruibal, Paula

AU - Wozniak, David M

AU - Pallasch, Elisa

AU - Wurr, Stephanie

AU - Bockholt, Sabrina

AU - Gómez-Medina, Sergio

AU - Qiu, Xiangguo

AU - Kobinger, Gary P

AU - Rodríguez, Estefanía

AU - Günther, Stephan

AU - Krasemann, Susanne

AU - Idoyaga, Juliana

AU - Oestereich, Lisa

AU - Muñoz-Fontela, César

PY - 2017/3/3

Y1 - 2017/3/3

N2 - Ebola virus (EBOV) causes severe systemic disease in humans and non-human primates characterized by high levels of viremia and virus titers in peripheral organs. The natural portals of virus entry are the mucosal surfaces and the skin where macrophages and dendritic cells (DCs) are primary EBOV targets. Due to the migratory properties of DCs, EBOV infection of these cells has been proposed as a necessary step for virus dissemination via draining lymph nodes and blood. Here we utilize chimeric mice with competent hematopoietic-driven immunity, to show that EBOV primarily infects CD11b(+) DCs in non-lymphoid and lymphoid tissues, but spares the main cross-presenting CD103(+) DC subset. Furthermore, depletion of CD8 and CD4 T cells resulted in loss of early control of virus replication, viremia and fatal Ebola virus disease (EVD). Thus, our findings point out at T cell function as a key determinant of EVD progress and outcome.

AB - Ebola virus (EBOV) causes severe systemic disease in humans and non-human primates characterized by high levels of viremia and virus titers in peripheral organs. The natural portals of virus entry are the mucosal surfaces and the skin where macrophages and dendritic cells (DCs) are primary EBOV targets. Due to the migratory properties of DCs, EBOV infection of these cells has been proposed as a necessary step for virus dissemination via draining lymph nodes and blood. Here we utilize chimeric mice with competent hematopoietic-driven immunity, to show that EBOV primarily infects CD11b(+) DCs in non-lymphoid and lymphoid tissues, but spares the main cross-presenting CD103(+) DC subset. Furthermore, depletion of CD8 and CD4 T cells resulted in loss of early control of virus replication, viremia and fatal Ebola virus disease (EVD). Thus, our findings point out at T cell function as a key determinant of EVD progress and outcome.

KW - Journal Article

U2 - 10.1038/srep43776

DO - 10.1038/srep43776

M3 - SCORING: Journal article

C2 - 28256637

VL - 7

SP - 43776

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

ER -