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Decreased frequency of intrathymic regulatory T cells in patients with myasthenia-associated thymoma

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Decreased frequency of intrathymic regulatory T cells in patients with myasthenia-associated thymoma. / Luther, C; Poeschel, S; Varga, M; Melms, A; Tolosa, E.

in: J NEUROIMMUNOL, Jahrgang 164, Nr. 1-2, 01.07.2005, S. 124-8.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Luther, C, Poeschel, S, Varga, M, Melms, A & Tolosa, E 2005, 'Decreased frequency of intrathymic regulatory T cells in patients with myasthenia-associated thymoma', J NEUROIMMUNOL, Jg. 164, Nr. 1-2, S. 124-8. https://doi.org/10.1016/j.jneuroim.2005.03.011

APA

Luther, C., Poeschel, S., Varga, M., Melms, A., & Tolosa, E. (2005). Decreased frequency of intrathymic regulatory T cells in patients with myasthenia-associated thymoma. J NEUROIMMUNOL, 164(1-2), 124-8. https://doi.org/10.1016/j.jneuroim.2005.03.011

Vancouver

Luther C, Poeschel S, Varga M, Melms A, Tolosa E. Decreased frequency of intrathymic regulatory T cells in patients with myasthenia-associated thymoma. J NEUROIMMUNOL. 2005 Jul 1;164(1-2):124-8. https://doi.org/10.1016/j.jneuroim.2005.03.011

Bibtex

@article{e45c62e2fc394f4eae55c4ffa675ccda,
title = "Decreased frequency of intrathymic regulatory T cells in patients with myasthenia-associated thymoma",
abstract = "Naturally occurring CD4+CD25+ regulatory T cells (Treg) are essential for the control of unwanted autoimmune responses. In this study, we analysed their frequency in peripheral blood and in the thymus/thymomas of patients with myasthenia gravis (MG). We found a marked decrease in the number of CD4+CD25+ thymocytes in MG-associated thymomas, but no differences in the peripheral compartment, suggesting that the thymic development of Treg might be impaired in these patients.",
keywords = "Adult, Age of Onset, Aged, Aged, 80 and over, Antigens, CD, CD4-Positive T-Lymphocytes, Female, Flow Cytometry, Humans, Immunohistochemistry, Male, Middle Aged, Myasthenia Gravis, Thymoma, Thymus Neoplasms",
author = "C Luther and S Poeschel and M Varga and A Melms and E Tolosa",
year = "2005",
month = jul,
day = "1",
doi = "10.1016/j.jneuroim.2005.03.011",
language = "English",
volume = "164",
pages = "124--8",
journal = "J NEUROIMMUNOL",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Decreased frequency of intrathymic regulatory T cells in patients with myasthenia-associated thymoma

AU - Luther, C

AU - Poeschel, S

AU - Varga, M

AU - Melms, A

AU - Tolosa, E

PY - 2005/7/1

Y1 - 2005/7/1

N2 - Naturally occurring CD4+CD25+ regulatory T cells (Treg) are essential for the control of unwanted autoimmune responses. In this study, we analysed their frequency in peripheral blood and in the thymus/thymomas of patients with myasthenia gravis (MG). We found a marked decrease in the number of CD4+CD25+ thymocytes in MG-associated thymomas, but no differences in the peripheral compartment, suggesting that the thymic development of Treg might be impaired in these patients.

AB - Naturally occurring CD4+CD25+ regulatory T cells (Treg) are essential for the control of unwanted autoimmune responses. In this study, we analysed their frequency in peripheral blood and in the thymus/thymomas of patients with myasthenia gravis (MG). We found a marked decrease in the number of CD4+CD25+ thymocytes in MG-associated thymomas, but no differences in the peripheral compartment, suggesting that the thymic development of Treg might be impaired in these patients.

KW - Adult

KW - Age of Onset

KW - Aged

KW - Aged, 80 and over

KW - Antigens, CD

KW - CD4-Positive T-Lymphocytes

KW - Female

KW - Flow Cytometry

KW - Humans

KW - Immunohistochemistry

KW - Male

KW - Middle Aged

KW - Myasthenia Gravis

KW - Thymoma

KW - Thymus Neoplasms

U2 - 10.1016/j.jneuroim.2005.03.011

DO - 10.1016/j.jneuroim.2005.03.011

M3 - SCORING: Journal article

C2 - 15923045

VL - 164

SP - 124

EP - 128

JO - J NEUROIMMUNOL

JF - J NEUROIMMUNOL

SN - 0165-5728

IS - 1-2

ER -