Decreased frequency of intrathymic regulatory T cells in patients with myasthenia-associated thymoma
Beteiligte Einrichtungen
Abstract
Naturally occurring CD4+CD25+ regulatory T cells (Treg) are essential for the control of unwanted autoimmune responses. In this study, we analysed their frequency in peripheral blood and in the thymus/thymomas of patients with myasthenia gravis (MG). We found a marked decrease in the number of CD4+CD25+ thymocytes in MG-associated thymomas, but no differences in the peripheral compartment, suggesting that the thymic development of Treg might be impaired in these patients.
Bibliografische Daten
Originalsprache | Englisch |
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ISSN | 0165-5728 |
DOIs | |
Status | Veröffentlicht - 01.07.2005 |
PubMed | 15923045 |
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