Decreased frequency of intrathymic regulatory T cells in patients with myasthenia-associated thymoma
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Decreased frequency of intrathymic regulatory T cells in patients with myasthenia-associated thymoma. / Luther, C; Poeschel, S; Varga, M; Melms, A; Tolosa, E.
In: J NEUROIMMUNOL, Vol. 164, No. 1-2, 01.07.2005, p. 124-8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Decreased frequency of intrathymic regulatory T cells in patients with myasthenia-associated thymoma
AU - Luther, C
AU - Poeschel, S
AU - Varga, M
AU - Melms, A
AU - Tolosa, E
PY - 2005/7/1
Y1 - 2005/7/1
N2 - Naturally occurring CD4+CD25+ regulatory T cells (Treg) are essential for the control of unwanted autoimmune responses. In this study, we analysed their frequency in peripheral blood and in the thymus/thymomas of patients with myasthenia gravis (MG). We found a marked decrease in the number of CD4+CD25+ thymocytes in MG-associated thymomas, but no differences in the peripheral compartment, suggesting that the thymic development of Treg might be impaired in these patients.
AB - Naturally occurring CD4+CD25+ regulatory T cells (Treg) are essential for the control of unwanted autoimmune responses. In this study, we analysed their frequency in peripheral blood and in the thymus/thymomas of patients with myasthenia gravis (MG). We found a marked decrease in the number of CD4+CD25+ thymocytes in MG-associated thymomas, but no differences in the peripheral compartment, suggesting that the thymic development of Treg might be impaired in these patients.
KW - Adult
KW - Age of Onset
KW - Aged
KW - Aged, 80 and over
KW - Antigens, CD
KW - CD4-Positive T-Lymphocytes
KW - Female
KW - Flow Cytometry
KW - Humans
KW - Immunohistochemistry
KW - Male
KW - Middle Aged
KW - Myasthenia Gravis
KW - Thymoma
KW - Thymus Neoplasms
U2 - 10.1016/j.jneuroim.2005.03.011
DO - 10.1016/j.jneuroim.2005.03.011
M3 - SCORING: Journal article
C2 - 15923045
VL - 164
SP - 124
EP - 128
JO - J NEUROIMMUNOL
JF - J NEUROIMMUNOL
SN - 0165-5728
IS - 1-2
ER -