Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice.
Beteiligte Einrichtungen
Abstract
Concanavalin A (con A) induces tumor necrosis factor (TNF)-dependent hepatocyte apoptosis resembling immune-mediated fulminant hepatic failure in humans. Intracellular pathways originating at the TNF receptor are either linked to apoptosis, nuclear factor (NF)-kappaB translocation, or Jun kinase (JNK) activation. The aim of this study was to study TNF-dependent pathways after con A injection in vivo.
Bibliografische Daten
| Originalsprache | Englisch |
|---|---|
| Aufsatznummer | 5 |
| ISSN | 0016-5085 |
| Status | Veröffentlicht - 1998 |
| pubmed | 9558294 |
|---|
