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Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice.

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Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. / Trautwein, C; Rakemann, T; Brenner, D A; Streetz, K; Licato, L; Manns, M P; Tiegs, Gisa.

in: GASTROENTEROLOGY, Jahrgang 114, Nr. 5, 5, 1998, S. 1035-1045.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Trautwein, C, Rakemann, T, Brenner, DA, Streetz, K, Licato, L, Manns, MP & Tiegs, G 1998, 'Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice.', GASTROENTEROLOGY, Jg. 114, Nr. 5, 5, S. 1035-1045. <http://www.ncbi.nlm.nih.gov/pubmed/9558294?dopt=Citation>

APA

Trautwein, C., Rakemann, T., Brenner, D. A., Streetz, K., Licato, L., Manns, M. P., & Tiegs, G. (1998). Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. GASTROENTEROLOGY, 114(5), 1035-1045. [5]. http://www.ncbi.nlm.nih.gov/pubmed/9558294?dopt=Citation

Vancouver

Trautwein C, Rakemann T, Brenner DA, Streetz K, Licato L, Manns MP et al. Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. GASTROENTEROLOGY. 1998;114(5):1035-1045. 5.

Bibtex

@article{a23a39cbecdb47d89e3136162f0bca73,
title = "Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice.",
abstract = "Concanavalin A (con A) induces tumor necrosis factor (TNF)-dependent hepatocyte apoptosis resembling immune-mediated fulminant hepatic failure in humans. Intracellular pathways originating at the TNF receptor are either linked to apoptosis, nuclear factor (NF)-kappaB translocation, or Jun kinase (JNK) activation. The aim of this study was to study TNF-dependent pathways after con A injection in vivo.",
keywords = "Animals, Male, Mice, Mice, Inbred BALB C, Apoptosis, NF-kappa B/metabolism, Cell Nucleus/metabolism, Biological Transport/physiology, Tumor Necrosis Factor-alpha/*pharmacology, Concanavalin A/*pharmacology, DNA/metabolism, Enzyme Activation/physiology, Intracellular Membranes/*drug effects/*metabolism, *JNK Mitogen-Activated Protein Kinases, Liver/*drug effects/*pathology, Lymphocyte Activation/physiology, MAP Kinase Kinase 4, *Mitogen-Activated Protein Kinase Kinases, Protein Kinases/metabolism, Proto-Oncogene Proteins c-jun/metabolism, T-Lymphocytes/physiology, Animals, Male, Mice, Mice, Inbred BALB C, Apoptosis, NF-kappa B/metabolism, Cell Nucleus/metabolism, Biological Transport/physiology, Tumor Necrosis Factor-alpha/*pharmacology, Concanavalin A/*pharmacology, DNA/metabolism, Enzyme Activation/physiology, Intracellular Membranes/*drug effects/*metabolism, *JNK Mitogen-Activated Protein Kinases, Liver/*drug effects/*pathology, Lymphocyte Activation/physiology, MAP Kinase Kinase 4, *Mitogen-Activated Protein Kinase Kinases, Protein Kinases/metabolism, Proto-Oncogene Proteins c-jun/metabolism, T-Lymphocytes/physiology",
author = "C Trautwein and T Rakemann and Brenner, {D A} and K Streetz and L Licato and Manns, {M P} and Gisa Tiegs",
year = "1998",
language = "English",
volume = "114",
pages = "1035--1045",
journal = "GASTROENTEROLOGY",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "5",

}

RIS

TY - JOUR

T1 - Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice.

AU - Trautwein, C

AU - Rakemann, T

AU - Brenner, D A

AU - Streetz, K

AU - Licato, L

AU - Manns, M P

AU - Tiegs, Gisa

PY - 1998

Y1 - 1998

N2 - Concanavalin A (con A) induces tumor necrosis factor (TNF)-dependent hepatocyte apoptosis resembling immune-mediated fulminant hepatic failure in humans. Intracellular pathways originating at the TNF receptor are either linked to apoptosis, nuclear factor (NF)-kappaB translocation, or Jun kinase (JNK) activation. The aim of this study was to study TNF-dependent pathways after con A injection in vivo.

AB - Concanavalin A (con A) induces tumor necrosis factor (TNF)-dependent hepatocyte apoptosis resembling immune-mediated fulminant hepatic failure in humans. Intracellular pathways originating at the TNF receptor are either linked to apoptosis, nuclear factor (NF)-kappaB translocation, or Jun kinase (JNK) activation. The aim of this study was to study TNF-dependent pathways after con A injection in vivo.

KW - Animals

KW - Male

KW - Mice

KW - Mice, Inbred BALB C

KW - Apoptosis

KW - NF-kappa B/metabolism

KW - Cell Nucleus/metabolism

KW - Biological Transport/physiology

KW - Tumor Necrosis Factor-alpha/pharmacology

KW - Concanavalin A/pharmacology

KW - DNA/metabolism

KW - Enzyme Activation/physiology

KW - Intracellular Membranes/drug effects/metabolism

KW - JNK Mitogen-Activated Protein Kinases

KW - Liver/drug effects/pathology

KW - Lymphocyte Activation/physiology

KW - MAP Kinase Kinase 4

KW - Mitogen-Activated Protein Kinase Kinases

KW - Protein Kinases/metabolism

KW - Proto-Oncogene Proteins c-jun/metabolism

KW - T-Lymphocytes/physiology

KW - Animals

KW - Male

KW - Mice

KW - Mice, Inbred BALB C

KW - Apoptosis

KW - NF-kappa B/metabolism

KW - Cell Nucleus/metabolism

KW - Biological Transport/physiology

KW - Tumor Necrosis Factor-alpha/pharmacology

KW - Concanavalin A/pharmacology

KW - DNA/metabolism

KW - Enzyme Activation/physiology

KW - Intracellular Membranes/drug effects/metabolism

KW - JNK Mitogen-Activated Protein Kinases

KW - Liver/drug effects/pathology

KW - Lymphocyte Activation/physiology

KW - MAP Kinase Kinase 4

KW - Mitogen-Activated Protein Kinase Kinases

KW - Protein Kinases/metabolism

KW - Proto-Oncogene Proteins c-jun/metabolism

KW - T-Lymphocytes/physiology

M3 - SCORING: Journal article

VL - 114

SP - 1035

EP - 1045

JO - GASTROENTEROLOGY

JF - GASTROENTEROLOGY

SN - 0016-5085

IS - 5

M1 - 5

ER -