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Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects.

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Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects. / Lill, Christina M; Liu, Tian; Schjeide, Brit-Maren M; Roehr, Johannes T; Akkad, Denis A; Damotte, Vincent; Alcina, Antonio; Ortiz, Miguel A; Arroyo, Rafa; Aitzkoa, Lopez de Lapuente; Blaschke, Paul; Winkelmann, Alexander; Gerdes, Lisa-Ann; Luessi, Felix; Fernadez, Oscar; Izquierdo, Guillermo; Antigüedad, Alfredo; Hoffjan, Sabine; Cournu-Rebeix, Isabelle; Gromöller, Silvana; Faber, Hans; Liebsch, Maria; Meissner, Esther; Chanvillard, Coralie; Touze, Emmanuel; Pico, Fernando; Corcia, Philippe; Dörner, Thomas; Steinhagen-Thiessen, Elisabeth; Baeckman, Lars; Heekeren, Hauke R; Li, Shu-Chen; Lindenberger, Ulman; Chan, Andrew; Hartung, Hans-Peter; Aktas, Orhan; Lohse, Peter; Kümpfel, Tania; Kubisch, Christian; Zettl, Uwe K; Fontaine, Bertrand; Vandenbroeck, Koen; Matesanz, Fuencisla; Urcelay, Elena; Bertram, Lars; Zipp, Frauke.

in: J MED GENET, Jahrgang 49, Nr. 9, 9, 2012, S. 558-562.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lill, CM, Liu, T, Schjeide, B-MM, Roehr, JT, Akkad, DA, Damotte, V, Alcina, A, Ortiz, MA, Arroyo, R, Aitzkoa, LDL, Blaschke, P, Winkelmann, A, Gerdes, L-A, Luessi, F, Fernadez, O, Izquierdo, G, Antigüedad, A, Hoffjan, S, Cournu-Rebeix, I, Gromöller, S, Faber, H, Liebsch, M, Meissner, E, Chanvillard, C, Touze, E, Pico, F, Corcia, P, Dörner, T, Steinhagen-Thiessen, E, Baeckman, L, Heekeren, HR, Li, S-C, Lindenberger, U, Chan, A, Hartung, H-P, Aktas, O, Lohse, P, Kümpfel, T, Kubisch, C, Zettl, UK, Fontaine, B, Vandenbroeck, K, Matesanz, F, Urcelay, E, Bertram, L & Zipp, F 2012, 'Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects.', J MED GENET, Jg. 49, Nr. 9, 9, S. 558-562. <http://www.ncbi.nlm.nih.gov/pubmed/22972946?dopt=Citation>

APA

Lill, C. M., Liu, T., Schjeide, B-M. M., Roehr, J. T., Akkad, D. A., Damotte, V., Alcina, A., Ortiz, M. A., Arroyo, R., Aitzkoa, L. D. L., Blaschke, P., Winkelmann, A., Gerdes, L-A., Luessi, F., Fernadez, O., Izquierdo, G., Antigüedad, A., Hoffjan, S., Cournu-Rebeix, I., ... Zipp, F. (2012). Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects. J MED GENET, 49(9), 558-562. [9]. http://www.ncbi.nlm.nih.gov/pubmed/22972946?dopt=Citation

Vancouver

Lill CM, Liu T, Schjeide B-MM, Roehr JT, Akkad DA, Damotte V et al. Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects. J MED GENET. 2012;49(9):558-562. 9.

Bibtex

@article{28b0d8b04d544b9ea06174188d5b5b87,
title = "Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects.",
abstract = "Single nucleotide polymorphisms (SNPs) rs429358 (?4) and rs7412 (?2), both invoking changes in the amino-acid sequence of the apolipoprotein E (APOE) gene, have previously been tested for association with multiple sclerosis (MS) risk. However, none of these studies was sufficiently powered to detect modest effect sizes at acceptable type-I error rates. As both SNPs are only imperfectly captured on commonly used microarray genotyping platforms, their evaluation in the context of genome-wide association studies has been hindered until recently.",
keywords = "Humans, Risk Factors, European Continental Ancestry Group/genetics, Polymorphism, Single Nucleotide/genetics, Databases, Genetic, *Genetic Association Studies, *Genetic Predisposition to Disease, Apolipoproteins E/*genetics, Multiple Sclerosis/*genetics, Humans, Risk Factors, European Continental Ancestry Group/genetics, Polymorphism, Single Nucleotide/genetics, Databases, Genetic, *Genetic Association Studies, *Genetic Predisposition to Disease, Apolipoproteins E/*genetics, Multiple Sclerosis/*genetics",
author = "Lill, {Christina M} and Tian Liu and Schjeide, {Brit-Maren M} and Roehr, {Johannes T} and Akkad, {Denis A} and Vincent Damotte and Antonio Alcina and Ortiz, {Miguel A} and Rafa Arroyo and Aitzkoa, {Lopez de Lapuente} and Paul Blaschke and Alexander Winkelmann and Lisa-Ann Gerdes and Felix Luessi and Oscar Fernadez and Guillermo Izquierdo and Alfredo Antig{\"u}edad and Sabine Hoffjan and Isabelle Cournu-Rebeix and Silvana Grom{\"o}ller and Hans Faber and Maria Liebsch and Esther Meissner and Coralie Chanvillard and Emmanuel Touze and Fernando Pico and Philippe Corcia and Thomas D{\"o}rner and Elisabeth Steinhagen-Thiessen and Lars Baeckman and Heekeren, {Hauke R} and Shu-Chen Li and Ulman Lindenberger and Andrew Chan and Hans-Peter Hartung and Orhan Aktas and Peter Lohse and Tania K{\"u}mpfel and Christian Kubisch and Zettl, {Uwe K} and Bertrand Fontaine and Koen Vandenbroeck and Fuencisla Matesanz and Elena Urcelay and Lars Bertram and Frauke Zipp",
year = "2012",
language = "English",
volume = "49",
pages = "558--562",
journal = "J MED GENET",
issn = "0022-2593",
publisher = "BMJ PUBLISHING GROUP",
number = "9",

}

RIS

TY - JOUR

T1 - Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects.

AU - Lill, Christina M

AU - Liu, Tian

AU - Schjeide, Brit-Maren M

AU - Roehr, Johannes T

AU - Akkad, Denis A

AU - Damotte, Vincent

AU - Alcina, Antonio

AU - Ortiz, Miguel A

AU - Arroyo, Rafa

AU - Aitzkoa, Lopez de Lapuente

AU - Blaschke, Paul

AU - Winkelmann, Alexander

AU - Gerdes, Lisa-Ann

AU - Luessi, Felix

AU - Fernadez, Oscar

AU - Izquierdo, Guillermo

AU - Antigüedad, Alfredo

AU - Hoffjan, Sabine

AU - Cournu-Rebeix, Isabelle

AU - Gromöller, Silvana

AU - Faber, Hans

AU - Liebsch, Maria

AU - Meissner, Esther

AU - Chanvillard, Coralie

AU - Touze, Emmanuel

AU - Pico, Fernando

AU - Corcia, Philippe

AU - Dörner, Thomas

AU - Steinhagen-Thiessen, Elisabeth

AU - Baeckman, Lars

AU - Heekeren, Hauke R

AU - Li, Shu-Chen

AU - Lindenberger, Ulman

AU - Chan, Andrew

AU - Hartung, Hans-Peter

AU - Aktas, Orhan

AU - Lohse, Peter

AU - Kümpfel, Tania

AU - Kubisch, Christian

AU - Zettl, Uwe K

AU - Fontaine, Bertrand

AU - Vandenbroeck, Koen

AU - Matesanz, Fuencisla

AU - Urcelay, Elena

AU - Bertram, Lars

AU - Zipp, Frauke

PY - 2012

Y1 - 2012

N2 - Single nucleotide polymorphisms (SNPs) rs429358 (?4) and rs7412 (?2), both invoking changes in the amino-acid sequence of the apolipoprotein E (APOE) gene, have previously been tested for association with multiple sclerosis (MS) risk. However, none of these studies was sufficiently powered to detect modest effect sizes at acceptable type-I error rates. As both SNPs are only imperfectly captured on commonly used microarray genotyping platforms, their evaluation in the context of genome-wide association studies has been hindered until recently.

AB - Single nucleotide polymorphisms (SNPs) rs429358 (?4) and rs7412 (?2), both invoking changes in the amino-acid sequence of the apolipoprotein E (APOE) gene, have previously been tested for association with multiple sclerosis (MS) risk. However, none of these studies was sufficiently powered to detect modest effect sizes at acceptable type-I error rates. As both SNPs are only imperfectly captured on commonly used microarray genotyping platforms, their evaluation in the context of genome-wide association studies has been hindered until recently.

KW - Humans

KW - Risk Factors

KW - European Continental Ancestry Group/genetics

KW - Polymorphism, Single Nucleotide/genetics

KW - Databases, Genetic

KW - Genetic Association Studies

KW - Genetic Predisposition to Disease

KW - Apolipoproteins E/genetics

KW - Multiple Sclerosis/genetics

KW - Humans

KW - Risk Factors

KW - European Continental Ancestry Group/genetics

KW - Polymorphism, Single Nucleotide/genetics

KW - Databases, Genetic

KW - Genetic Association Studies

KW - Genetic Predisposition to Disease

KW - Apolipoproteins E/genetics

KW - Multiple Sclerosis/genetics

M3 - SCORING: Journal article

VL - 49

SP - 558

EP - 562

JO - J MED GENET

JF - J MED GENET

SN - 0022-2593

IS - 9

M1 - 9

ER -