Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects.
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Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects. / Lill, Christina M; Liu, Tian; Schjeide, Brit-Maren M; Roehr, Johannes T; Akkad, Denis A; Damotte, Vincent; Alcina, Antonio; Ortiz, Miguel A; Arroyo, Rafa; Aitzkoa, Lopez de Lapuente; Blaschke, Paul; Winkelmann, Alexander; Gerdes, Lisa-Ann; Luessi, Felix; Fernadez, Oscar; Izquierdo, Guillermo; Antigüedad, Alfredo; Hoffjan, Sabine; Cournu-Rebeix, Isabelle; Gromöller, Silvana; Faber, Hans; Liebsch, Maria; Meissner, Esther; Chanvillard, Coralie; Touze, Emmanuel; Pico, Fernando; Corcia, Philippe; Dörner, Thomas; Steinhagen-Thiessen, Elisabeth; Baeckman, Lars; Heekeren, Hauke R; Li, Shu-Chen; Lindenberger, Ulman; Chan, Andrew; Hartung, Hans-Peter; Aktas, Orhan; Lohse, Peter; Kümpfel, Tania; Kubisch, Christian; Zettl, Uwe K; Fontaine, Bertrand; Vandenbroeck, Koen; Matesanz, Fuencisla; Urcelay, Elena; Bertram, Lars; Zipp, Frauke.
In: J MED GENET, Vol. 49, No. 9, 9, 2012, p. 558-562.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects.
AU - Lill, Christina M
AU - Liu, Tian
AU - Schjeide, Brit-Maren M
AU - Roehr, Johannes T
AU - Akkad, Denis A
AU - Damotte, Vincent
AU - Alcina, Antonio
AU - Ortiz, Miguel A
AU - Arroyo, Rafa
AU - Aitzkoa, Lopez de Lapuente
AU - Blaschke, Paul
AU - Winkelmann, Alexander
AU - Gerdes, Lisa-Ann
AU - Luessi, Felix
AU - Fernadez, Oscar
AU - Izquierdo, Guillermo
AU - Antigüedad, Alfredo
AU - Hoffjan, Sabine
AU - Cournu-Rebeix, Isabelle
AU - Gromöller, Silvana
AU - Faber, Hans
AU - Liebsch, Maria
AU - Meissner, Esther
AU - Chanvillard, Coralie
AU - Touze, Emmanuel
AU - Pico, Fernando
AU - Corcia, Philippe
AU - Dörner, Thomas
AU - Steinhagen-Thiessen, Elisabeth
AU - Baeckman, Lars
AU - Heekeren, Hauke R
AU - Li, Shu-Chen
AU - Lindenberger, Ulman
AU - Chan, Andrew
AU - Hartung, Hans-Peter
AU - Aktas, Orhan
AU - Lohse, Peter
AU - Kümpfel, Tania
AU - Kubisch, Christian
AU - Zettl, Uwe K
AU - Fontaine, Bertrand
AU - Vandenbroeck, Koen
AU - Matesanz, Fuencisla
AU - Urcelay, Elena
AU - Bertram, Lars
AU - Zipp, Frauke
PY - 2012
Y1 - 2012
N2 - Single nucleotide polymorphisms (SNPs) rs429358 (?4) and rs7412 (?2), both invoking changes in the amino-acid sequence of the apolipoprotein E (APOE) gene, have previously been tested for association with multiple sclerosis (MS) risk. However, none of these studies was sufficiently powered to detect modest effect sizes at acceptable type-I error rates. As both SNPs are only imperfectly captured on commonly used microarray genotyping platforms, their evaluation in the context of genome-wide association studies has been hindered until recently.
AB - Single nucleotide polymorphisms (SNPs) rs429358 (?4) and rs7412 (?2), both invoking changes in the amino-acid sequence of the apolipoprotein E (APOE) gene, have previously been tested for association with multiple sclerosis (MS) risk. However, none of these studies was sufficiently powered to detect modest effect sizes at acceptable type-I error rates. As both SNPs are only imperfectly captured on commonly used microarray genotyping platforms, their evaluation in the context of genome-wide association studies has been hindered until recently.
KW - Humans
KW - Risk Factors
KW - European Continental Ancestry Group/genetics
KW - Polymorphism, Single Nucleotide/genetics
KW - Databases, Genetic
KW - Genetic Association Studies
KW - Genetic Predisposition to Disease
KW - Apolipoproteins E/genetics
KW - Multiple Sclerosis/genetics
KW - Humans
KW - Risk Factors
KW - European Continental Ancestry Group/genetics
KW - Polymorphism, Single Nucleotide/genetics
KW - Databases, Genetic
KW - Genetic Association Studies
KW - Genetic Predisposition to Disease
KW - Apolipoproteins E/genetics
KW - Multiple Sclerosis/genetics
M3 - SCORING: Journal article
VL - 49
SP - 558
EP - 562
JO - J MED GENET
JF - J MED GENET
SN - 0022-2593
IS - 9
M1 - 9
ER -